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Catalog	name	Description	price
R-C-470	PHA665752 CAS:477575-56-7	PHA-665752 is a selective,ATP-competitive,and active-site inhibitor of the catalytic activity of c-Met kinase (Ki=4 nM;IC50=9 nM).PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases.PHA-665752 induces apoptosis and cell cycle arrest,and exhibits cytoreductive antitumor activity.	price>
R-R-2170	SBP-7455 CAS No.1884222-74-5	SBP-7455/CAS No.1884222-74-5 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research.	price>
R-C-471	Tasisulam(LY573636) CAS:519055-63-1	LY573636 is a potent anti-tumor agent,which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo.LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.	price>
R-R-2171	6-CEPN CAS No.1054549-73-3	6-CEPN/CAS No.1054549-73-3 is a RAS inhibitor. 6-CEPN can inhibit RAS activation by binding to Icmt binding sites. 6-CEPN has anticancer activity. 6-CEPN can block cancer cells in the G1 phase. 6-CEPN can induce autophagy and necrosis of Cancer cells (Icmt: isovalerylcysteine carboxymethyltransferase).	price>
R-C-472	AZD8055 CAS:1009298-09-2	AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity(∼1,000-fold) against PI3K isoforms and ATM/DNA-PK.AZD8055 induces caspase-dependent apoptosis and also induces autophagy.	price>
R-R-2172	ATG7-IN-3 CAS No.2226229-76-9	ATG7-IN-3 (compound 18)/CAS No.2226229-76-9 is a potent ATG7 inhibitor, with an IC50 of 0.048 μM. ATG7-IN-3 inhibits autophagy. ATG7-IN-3 inhibits the formation of endogenous LC3B puncta in the neuroglioma cell line H4.	price>
R-C-473	KU0063794 CAS:938440-64-3	KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of 10 nM in cell-free assays;no effect on PI3Ks.KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR)(IC50 10 nM for mTORC1 and mTORC2 respectively).	price>
R-R-2173	CC214-2 CAS No.1228012-18-7	CC214-2/CAS No.1228012-18-7 is an oral active and selective mTOR kinase inhibitor. CC214-2 targets to both of mTORC1 (pS6) and mTORC2 (pAktS473). CC214-2 induces autophagy, which is a potential target for host-directed therapy (HDT) in tuberculosis. CC214-2 exhibits synergistic bactericidal and sterilizing activity agasinst tuberculosis (TB), and shortens the treatment duration. CC214-2 also inhibits Rapamycin (HY-10219)-resistant signaling and the growth of glioblastomas in vitro and in vivo.	price>
R-C-474	Enzalutamide (MDV3100) CAS:915087-33-1	MDV3100 is androgen-receptor inhibitor.Highly recommended inhibitor in AR research.Enzalutamide(MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.Enzalutamide is shown to increase autophagy.	price>
R-R-2174	ICCB-19 hydrochloride CAS No.1803605-68-6	ICCB-19 hydrochloride/CAS No.1803605-68-6 is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins.	price>
R-C-475	AST-1306 CAS:897383-62-9	AST-1306,a novel anilino-quinazoline compound,inhibits the enzymatic activities of wild-type epidermal growth factor receptor(EGFR)and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems.It is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM,also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.	price>
R-R-2175	20-Deoxyingenol CAS No.54706-99-9	20-Deoxyingenol/CAS No.54706-99-9, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA).	price>
R-C-476	Apixaban CAS:503612-47-3	Apixaban(BMS 562247-01) is a highly selective,reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit,respectively.Apixaban is an anticoagulant for the prevention of venous thromboembolism and venous thromboembolic events.	price>
R-R-2176	Atg4B-IN-2 CAS No.2765008-88-4	Atg4B-IN-2/CAS No.2765008-88-4 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition.	price>
R-C-477	MGCD0103 CAS:726169-73-9	MGCD0103(Mocetinostat)is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1(HDAC1),but also HDAC2,HDAC3,and HDAC11.It is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2-to10-fold selectivity against HDAC2,3,and 11,and no activity to HDAC4,5,6,7,and 8.Mocetinostat (MGCD0103) induces apoptosis and autophagy.	price>
R-R-2177	P62-mediated mitophagy inducer CAS No.1809031-84-2	P62-mediated mitophagy inducer (PMI)/CAS No.1809031-84-2 is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential.	price>
R-C-478	Foretinib(XL880) CAS:849217-64-7	Foretinib(GSK1363089,EXEL-2880,XL-880) is an ATP-competitive inhibitor of HGFR and VEGFR,mostly for Met (c-Met)and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays.Less potent against Ron,Flt-1/3/4,Kit (c-Kit), PDGFRα/β and Tie-2,and little activity to FGFR1 and EGFR.	price>
R-R-2178	HDAC10-IN-1	HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.	price>
R-C-479	Glesatinib(MGCD265) CAS:875337-44-3	MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs,including the c-Met receptor (HGFR);the Tek/Tie-2 receptor;VEGFR types 1,2,and 3;and MST1R.	price>
R-R-2179	HDAC10-IN-2 hydrochloride	HDAC10-IN-2 hydrochloride (compound 10c) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. HDAC10-IN-2 hydrochloride modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.	price>

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