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Catalog	name	Description	price
R-C-480	Roscovitine (Seliciclib) CAS:186692-46-6	Roscovitine (Seliciclib,CYC202) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM,0.7 μM and 0.16 μM in cell-free assays.It shows little effect on CDK4/6.	price>
R-R-2180	Daurisoline CAS No.70553-76-3	Daurisoline/CAS No.70553-76-3 is a hERG inhibitor and also an autophagy blocker.	price>
R-C-481	sns032 CAS:345627-80-7	SNS-032(BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10-and 20-fold selective over CDK1/CDK4.It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6.SNS-032 (BMS-387032) induces apoptosi.	price>
R-R-2181	Thonningianin B CAS No.271579-12-5	Thonningianin B/CAS No.271579-12-5 is an antioxidant and an autophagy enhancer.	price>
R-C-482	ABT-263(Navitoclax) CAS:923564-51-6	ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki of <1 nmol/L for Bcl-2,Bcl-xL,and Bcl-w).it maintains a high affinity for Bcl-xL,Bcl-2,and Bcl-w,(Ki ≤1 nmol/L),but binds more weakly to Mcl-1 and A1.	price>
R-R-2182	Tat-beclin 1 CAS No.1423821-88-8	Tat-beclin 1/CAS No.1423821-88-8, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).	price>
R-C-483	ABT-737 cas:852808-04-9	ABT-737 is a pan-Bcl-2 inhibitor.IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10μM (Nalm-6,K562 and HL-60).	price>
R-R-2183	Metformin-d6 hydrochloride CAS No.1185166-01-1	Metformin-d6 (hydrochloride)/CAS No.1185166-01-1 is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy.	price>
R-C-484	NVP-BGJ398 cas:872511-34-7	Infigratinib(BGJ-398; NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM,1.4 nM,1 nM,and 60 nM for FGFR1,FGFR2,FGFR3,and FGFR4, respectively.	price>
R-R-2184	Pennogenin 3-O-beta-chacotrioside CAS No.55916-52-4	Pennogenin 3-O-beta-chacotrioside/CAS No.55916-52-4 is an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. Anti-colorectal cancer activity.	price>
R-C-485	BAY73-4506(Regorafenib) cas:755037-03-7	Regorafenib (BAY73-4506,Fluoro-Sorafenib,Resihance,Stivarga) is a multi-target inhibitor for VEGFR1,VEGFR2,VEGFR3,PDGFRβ,Kit (c-Kit),RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM,22 nM,7nM,1.5 nM and 2.5 nM in cell-free assays,respectively.Regorafenib induces autophag.	price>
R-R-2185	Aumitin CAS No.946293-78-3	Aumitin/CAS No.946293-78-3 is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively.	price>
R-C-486	Roflumilast,Daxas cas:162401-32-3	Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7,0.9,0.7,and 0.2 nM for PDE4A1,PDEA4,PDEB1,and PDEB2,respectively,without affecting PDE1,PDE2, PDE3 or PDE5 isoenzymes from various cells.	price>
R-R-2186	Paclitaxel-d5 (benzoyloxy) CAS No.1261254-56-1	Paclitaxel-d5 (benzoyloxy)/CAS No.1261254-56-1 is the deuterium labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.	price>
R-C-487	Fasudil hydrochloride cas:105628-07-7	Fasudil Hydrochloride (HA-1077 Hydrochloride;AT877 Hydrochloride),is a nonspecific ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1,IC50s of 0.158 μM and 4.58 μM,12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively.Fasudil Hydrochloride is also a potent Ca2+channel antagonist and vasodilator.	price>
R-R-2187	3BDO CAS No.890405-51-3	3BDO/CAS No.890405-51-3 is a new mTOR activator which can also inhibit autophagy.	price>
R-C-488	Pelitinib(EKB-569) cas:257933-82-7	Pelitinib(EKB-569;WAY-EKB 569)is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM;also slightly inhibits Src,MEK/ERK and ErbB2 with IC50s of 282,800,and 1255 nM,respectively.	price>
R-R-2188	Obeticholic acid-d5 CAS No.1992000-80-2	Obeticholic acid-d5/CAS No.1992000-80-2 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy.	price>
R-C-489	Neratinib(HKI-272) cas:698387-09-6	Neratinib(HKI-272)is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays;weakly inhibits KDR and Src,no significant inhibition to Akt,CDK1/2/4,IKK-2,MK-2,PDK1,c-Raf and c-Met.	price>
R-R-2189	Obeticholic Acid-d4	Obeticholic Acid-d4 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy.	price>

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