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Catalog	name	Description	price
R-C-505	Canetinib cas:267243-28-7	Canertinib(CI-1033,PD183805)is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM,no activity to PDGFR, FGFR,InsR,PKC,or CDK1/2/4.	price>
R-R-2205	Glyburide-d3 CAS No.1219803-02-7	Glyburide-d3/CAS No.1219803-02-7 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. Glibenclamide can induce autophagy.	price>
R-C-506	Laquinimod cas:248281-84-7	Laquinimod is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system.	price>
R-R-2206	Metformin hydrochloride CAS No.1115-70-4	Metformin hydrochloride/CAS No.1115-70-4 inhibits the mitochondrial respiratory chain in the liver, it can lead to the activation of AMPK and improve insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy.	price>
R-C-507	Mastinib cas:790299-79-5	Masitinib(AB1010)is a potent,orally bioavailable,and selective inhibitor of c-Kit(IC50=200 nM for human recombinant c-Kit).It also inhibits PDGFRα/β(IC50s=540/800 nM),Lyn(IC50= 510 nM for LynB),Lck,and,to a lesser extent,FGFR3 and FAK.Masitinib (AB1010) has anti-proliferative,pro-apoptotic activity and low toxicity.	price>
R-R-2207	EACC CAS No.864941-31-1	EACC/CAS No.864941-31-1 is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion.	price>
R-C-508	Torcetrapib cas:262352-17-0	Torcetrapib(CP-529414)is a CETP inhibitor with IC50 of 37 nM,elevates HDL-C and reduces nonHDL-C in plasma.	price>
R-R-2208	Gartanin CAS No.33390-42-0	Gartanin/CAS No.33390-42-0 is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells.	price>
R-C-509	Tasosartan cas:145733-36-4	Tasosartan is a long-acting angiotensin II(AngII)receptor antagonist.	price>
R-R-2209	DCAP CAS No.500015-20-3	DCAP/CAS No.500015-20-3 is a broad-spectrum antibiotic targeting the membranes of both Gram-positive and Gram-negative bacteria. DCAP blocks autophagy at the late stages by preventing autophagolysosome maturation and interrupting the autophagic flux.	price>
R-C-510	A-803467 cas:944261-79-4	A 803467 is a selective blocker of NaV1.8 channels(IC50 values are 8,2450,6740, 7340 and 7380 nM for hNaV1.8,hNaV1.3,hNaV1.7,hNaV1.5 and hNaV1.2 channels respectively).	price>
R-R-2210	Isorhapontigenin CAS No.32507-66-7	Isorhapontigenin/CAS No.32507-66-7, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation.	price>
R-C-511	JTC801 cas:244218-51-7	JTC-801 is a selective opioid receptor-like1(ORL1) receptor antagonist with IC50 of 94 nM,weakly inhibits receptors δ,κ,and μ.	price>
R-R-2211	DC-LC3in-D5 CAS No.2868312-73-4	DC-LC3in-D5/CAS No.2868312-73-4 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination researchs in cancer through inhibiting autophagy.	price>
R-C-512	Pyroxamide cas:382180-17-8	Pyroxamide is a potent inhibitor of histone deacetylase 1(HDAC1) with an ID50 of 100 nM.Pyroxamide can in duce apoptosis and cell cycle arrest in leukemia.	price>
R-R-2212	Autogramin-1 CAS No.2375541-73-2	Autogramin-1/CAS No.2375541-73-2 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM).	price>
R-C-513	CP466722 cas：1080622-86-1	CP-466722 is a rapidly reversible inhibitor of ATM,with an IC50 of 4.1 μM,and has no effects on PI3K or closely related PI3K-like protein kinase (PIKK) family members.	price>
R-R-2213	U0126 CAS No.109511-58-2	U0126/CAS No.109511-58-2 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor.	price>
R-C-514	PF-562771 cas:834894-21-2	AP23464 and PF-562771(AP23848) potently and selectively target activation-loop mutants of Kit in vitro and in vivo and could have therapeutic potential against D816V-expressing malignancies.Src/Abl inhibitors are compatible with imatinib and suggest that combined Abl inhibitor therapy is a feasible treatment strategy for patients with CML.	price>
R-R-2214	STF-62247 CAS No.315702-99-9	STF-62247/CAS No.315702-99-9 is an autophagy inducer that selectively cytotoxic to VHL-deficient renal cell carcinoma (IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively).	price>

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