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Catalog	name	Description	price
R-R-2158	Crustecdysone CAS No.5289-74-7	Crustecdysone (20-Hydroxyecdysone)/CAS No.5289-74-7 is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).	price>
R-C-459	GSK690693 CAS:937174-76-0	Gsk690693 is a pan Akt inhibitor targeting AKT1/2/3.The IC50 of gsk690693 is 2 nm /13nm/9 nm in cell-free analysis.Gsk690693 is also sensitive to pKa,PrKX and PKC isozymes of AGC kinase family.Gsk690693 also inhibited AMPK and dapk3 of CaMK family with IC50 of 50nm and 81nm,respectively.	price>
R-R-2159	Autophagy inducer 3 CAS No.2691054-63-2	Autophagy inducer 3/CAS No.2691054-63-2 has autophagy induced activity. Autophagy inducer 3 possesses robust autophagic cell death in diverse cancer cells sparing normal counterpart. Autophagy inducer 3 induces lethal autophagy by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins.	price>
R-C-460	PF-04691502 CAS:1013101-36-4	PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1,p70S6K,MEK,ERK,p38,or JNK. PF-04691502 induces apoptosis.	price>
R-R-2160	AUTEN-67 CAS No.1783800-77-0	AUTEN-67 (Autophagy enhancer-67)/CAS No.1783800-77-0 is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease.	price>
R-C-461	SRT1720 CAS:1001645-58-4	SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM,and shows less potent activities agaiinst SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM,respectively.	price>
R-R-2161	Vps34-IN-4 CAS No.1383716-46-8	Vps34-IN-4 (compound 19)/CAS No.1383716-46-8 is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components.	price>
R-C-462	PP242 CAS:1092351-67-1	Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays;targets both mTOR complexes with>10-and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ,respectively.Torkinib (PP242) induces mitophagy and apoptosis.	price>
R-R-2162	mTOR inhibitor-8 CAS No.2489196-70-3	mTOR inhibitor-8/CAS No.2489196-70-3 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells.	price>
R-C-463	KW-2478 cas:819812-04-9	KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.	price>
R-R-2163	Rapamycin-d3 CAS No.392711-19-2	Rapamycin-d3/CAS No.392711-19-2 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.	price>
R-C-464	YM201636 cas:371942-69-7	YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM.YM-201636 inhibits retroviral replic.	price>
R-R-2164	Corynoxine CAS No.6877-32-3	Corynoxine/CAS No.6877-32-3, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway.	price>
R-C-465	ms-275 CAS:209783-80-2	Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays,compared with HDACs 4,6,8,and 10.Entinostat induces autophagy and apoptosis.MS 275 is also offered as part of the Tocriscreen 2.0 Max,Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library.	price>
R-R-2165	ATG7-IN-2 CAS No.2226227-75-2	ATG7-IN-2 (compound 1)/CAS No.2226227-75-2 is a potent ATG7 inhibitor, with an IC50 of 0.089 μM. ATG7-IN-2 inhibits autophagy marker LC3B.	price>
R-C-466	PI-103 cas:371935-74-9	PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays,less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM.PI-103 induces apoptosis in murine T-cell Lymphoma.	price>
R-R-2166	GPP78 CAS No.1202580-59-3	GPP78 (CAY10618)/CAS No.1202580-59-3 is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects.	price>
R-C-467	PKI-402 cas:1173204-81-3	PKI-402 is a potent dual pan-PI3K/mTOR inhibitor targeting PI3Kα/β/γ/δ and mTOR with IC50 of 2 nM/7 nM/16 nM/14 nM and 3 nM,respectively;also potent to PI3Kα mutants E545K and H1047R.	price>
R-R-2167	MRT67307 CAS No.1190378-57-4	MRT67307/CAS No.1190378-57-4 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells.	price>
R-C-468	GDC0980 CAS:1032754-93-0	GDC-0980 selectively inhibits the activities against class I PI3K and mTOR kinase with a Ki of 17 nM for mTOR (FRAP) and IC50 of 5 nM,27 nM,7nM,and 14 nM for PI3Kα,β,δ,and γ,respectively. GDC-0980 significantly inhibits cell proliferation in PC3 and MCF7 cells.	price>

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