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Catalog	name	Description	price
R-C-490	Imatinib cas:152459-95-5	Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL,v-Abl,PDGFR and c-kit kinase activity.Imatinib (STI571) works by binding close to the ATP binding site,locking it in a closed or self-inhibited conformation,therefore inhibiting the enzyme activity of the protein semicompetitively.Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.	price>
R-R-2190	Venetoclax-d8 CAS No.1257051-06-1	Venetoclax-d8/CAS No.1257051-06-1 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy.	price>
R-C-491	Erlotinib HCL cas:183319-69-9	Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved.Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor.For the signal to be transmitted,two EGFR molecules need to come together to form a homodimer.These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues,which generates phosphotyrosine residues,recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processesWhen erlotinib binds to EGFR,formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.	price>
R-R-2191	SMER18 CAS No.944153-47-3	SMER18/CAS No.944153-47-3 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.	price>
R-C-492	Afatinib(BIBW2992) cas:439081-18-2	BIBW2992(Afatinib)is tyrosine kinase inhibitor(TKI)that irreversibly inhibits human epidermal growth factor receptor 2(Her2)and epidermal growth factor receptor(EGFR) kinases.	price>
R-R-2192	CA-5f CAS No.1370032-19-1	CA-5f/CAS No.1370032-19-1 is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity.	price>
R-C-493	PCI-32765 cas:936563-96-1	Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk)inhibitor with IC50 of 0.5 nM in cell-free assays,modestly potent to Bmx, CSK,FGR,BRK,HCK,less potent to EGFR Yes,ErbB2,JAK3etc.Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.	price>
R-R-2193	Elaiophylin CAS No.37318-06-2	Elaiophylin (Azalomycin B; Gopalamicin; Efomycin E)/CAS No.37318-06-2 is an autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells.	price>
R-C-494	AP24534(Ponatinib) cas:943319-70-8	Ponatinib(AP24534)is a novel,potent multi-target inhibitor of Abl,PDGFRα, VEGFR2,FGFR1 and Src with IC50 of 0.37 nM,1.1 nM,1.5 nM,2.2 nM and 5.4 nM in cell-free assays,respectively.Ponatinib (AP24534) inhibits autophagy.	price>
R-R-2194	Nortriptyline hydrochloride CAS No.894-71-3	Nortriptyline (Desmethylamitriptyline) hydrochloride/CAS No.894-71-3, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects.	price>
R-C-495	AT101 CAS:90141-22-3	AT101,the R-(-) enantiomer of Gossypol acetic acid,binds with Bcl-2,Bcl-xL and Mcl-1 with Ki of 0.32μM,0.48μM and 0.18μM.	price>
R-R-2195	UBCS039 CAS No.358721-70-7	UBCS039/CAS No.358721-70-7 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM.	price>
R-C-496	AZD5438 cas:602306-29-6	AZD-5438 is a potent CDK1,CDK2,and CDK9 inhibitor,with IC50s of 16 nM,6 nM,and 20 nM in cell-free assays,respectively.AZD-5438 shows less inhibition activity against GSK3β,CDK5 and CDK6 .	price>
R-R-2196	Nortriptyline CAS No.72-69-5	Nortriptyline (Desmethylamitriptyline)/CAS No.72-69-5, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects.	price>
R-C-497	CX-4945 CAS:1009820-21-6	Silmitasertib(CX-4945) is a potent and selective inhibitor of CK2(casein kinase 2)with IC50 of 1 nM in a cell-free assay,less potent to Flt3,Pim1 and CDK1 (inactive in cell-based assay).Silmitasertib induces autophagy and promotes apoptosis.	price>
R-R-2197	Desethyl chloroquine CAS No.1476-52-4	Desethyl chloroquine/CAS No.1476-52-4 is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.	price>
R-C-498	LY2109761 cas:700874-71-1	LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay,respectively;shown to negatively affect the phosphorylation of Smad2.LY2109761 blocks autophagy and induces apoptosis.	price>
R-R-2198	S130 CAS No.1160852-22-1	S130/CAS No.1160852-22-1 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 µM. S130 suppresses autophagy flux.	price>
R-C-499	RAF265 cas:927880-90-8	RAF265(CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM,and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays.RAF265 (CHIR-265)induces cell cycle arrest and apoptosis.	price>
R-R-2199	Wogonoside CAS No.51059-44-0	Wogonoside/CAS No.51059-44-0, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway.	price>

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