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Catalog	name	Description	price
R-R-2146	Acetyl Coenzyme A trisodium CAS No.102029-73-2	Acetyl-coenzyme A (Acetyl-CoA) trisodium/CAS No.102029-73-2 is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis.	price>
R-C-447	Moxifloxacin	Moxifloxacin(BAY12-8039)is a fourth-generation synthetic fluoroquinolone antibacterial agent.Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis,acute bacterial exacerbations of chronic bronchitis,and community-acquired pneumonia.	price>
R-R-2147	Dimethyl fumarate-d2 CAS No.23057-98-9	Dimethyl fumarate-d2/CAS No.23057-98-9 is the deuterium labeled Dimethyl fumarate. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.	price>
R-C-448	NPS-2143	Nps-2143(sb-262470a),an oral active calcium solubilizer,is a selective calcium sensitive receptor(CaSR)antagonist.Nps-2143(sb-262470a)increased the cytosolic Ca2+concentration (IC50=43 nm) by activating Ca2+receptor in HEK 293 cells expressing human Ca2 + receptor.	price>
R-R-2148	CA77.1 CAS No.2412270-22-3	CA77.1/CAS No.2412270-22-3 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in lysosomes.	price>
R-C-449	Rucaparib (AG-014699) phosphate cas:459868-92-9	Rucaparib(AG-014699,PF-01367338)is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay,also showing binding affinity to eight other PARP domains.	price>
R-R-2149	Carvedilol-d4 CAS No.1133705-56-2	Carvedilol-d4/CAS No.1133705-56-2 is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome.	price>
R-C-450	Selumetinib(AZD6244) CAS:606143-52-6	Selumetinib(AZD6244,ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2.It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM,no inhibition to p38α,MKK6,EGFR,ErbB2, ERK2,B-Raf,etc.Selumetinib suppresses cell proliferation,migration and trigger apoptosis.	price>
R-R-2150	Acacetin CAS No.480-44-4	Acacetin/CAS No.480-44-4 is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research.	price>
R-C-451	GSK1070916 CAS:942918-07-2	GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/Cwith IC50 of 3.5 nM/6.5 nM.It displays 100-fold selectivity against the closely related Aurora A-TPX2 complex.	price>
R-R-2151	Forskolin CAS No.66575-29-9	Forskolin (Coleonol)/CAS No.66575-29-9 is a potent activator of adenylate cyclase with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces the differentiation of various cell types and activates the pregnane X receptors (PXR) and FXR. Forskolin exerts an inotropic effect on the heart and has antiplatelet and antihypertensive actions. Forskolin also induces autophagy.	price>
R-C-452	Trametinib（GSK1120212) CAS:871700-17-3	Trametinib (GSK1120212,JTP-74057, Mekinist)is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays,no inhibition of the kinase activities of c-Raf,B-Raf,ERK1/2.Trametinib activates autophagy and induces apoptosis.	price>
R-R-2152	Trimetazidine CAS No.5011-34-7	Trimetazidine/CAS No.5011-34-7 is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.	price>
R-C-453	A-674563 CAS:552325-73-2	A-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays,modest potent to PKA and 30-fold selective for Akt1 over PKC.	price>
R-R-2153	Trimetazidine dihydrochloride CAS No.13171-25-0	Trimetazidine dihydrochloride/CAS No.13171-25-0 is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.	price>
R-C-454	Alisertib(MLN8237) CAS:1028486-01-2	Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay.It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest,apoptosis and autophagy.	price>
R-R-2154	Gefitinib-d6 CAS No.1228664-49-0	Gefitinib-d6/CAS No.1228664-49-0 is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.	price>
R-C-455	AS605240 CAS:648450-29-7	AS-605240 selectively inhibits PI3Kγwith IC50 of 8 nM,over 30-fold and 7.5-fold more selective for PI3Kγ than PI3Kδ/β and PI3Kα in cell-free assays, respectively.	price>
R-R-2155	Liensinine Diperchlorate CAS No.5088-90-4	Liensinine Diperchlorate/CAS No.5088-90-4 is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc.	price>
R-C-456	Dibenzazepine (YO-01027) CAS:209984-56-5	Yo-01027 is a dipeptide type γ-secretase inhibitor with IC50 of 2.6 nm and 2.9 nm,respectively.Yo-01027 is an anti Alzheimer drug.Yo-01027 interacts directly with γ-secretase complex.Different from other γ-secretase inhibitors,yo-01027 targets different functional domains of the complex.Yo-01027 targets the N-terminal presenilin fragment and another gamma secretase inhibitor compound E(CPN E),while dfk167 and dapt bind to the catalytic sites of presenilin aspartate protease subunit and C-terminal presenilin fragment,respectively.In one study,yo-01027 and cpne showed no significant difference in blocking appl and notch cleavage,indicating that the IC50 values of the two substrates were statistically equal.	price>

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