Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-2210	Isorhapontigenin CAS No.32507-66-7	Isorhapontigenin/CAS No.32507-66-7, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation.	price>
R-C-511	JTC801 cas:244218-51-7	JTC-801 is a selective opioid receptor-like1(ORL1) receptor antagonist with IC50 of 94 nM,weakly inhibits receptors δ,κ,and μ.	price>
R-R-2211	DC-LC3in-D5 CAS No.2868312-73-4	DC-LC3in-D5/CAS No.2868312-73-4 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination researchs in cancer through inhibiting autophagy.	price>
R-C-512	Pyroxamide cas:382180-17-8	Pyroxamide is a potent inhibitor of histone deacetylase 1(HDAC1) with an ID50 of 100 nM.Pyroxamide can in duce apoptosis and cell cycle arrest in leukemia.	price>
R-R-2212	Autogramin-1 CAS No.2375541-73-2	Autogramin-1/CAS No.2375541-73-2 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM).	price>
R-C-513	CP466722 cas：1080622-86-1	CP-466722 is a rapidly reversible inhibitor of ATM,with an IC50 of 4.1 μM,and has no effects on PI3K or closely related PI3K-like protein kinase (PIKK) family members.	price>
R-R-2213	U0126 CAS No.109511-58-2	U0126/CAS No.109511-58-2 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor.	price>
R-C-514	PF-562771 cas:834894-21-2	AP23464 and PF-562771(AP23848) potently and selectively target activation-loop mutants of Kit in vitro and in vivo and could have therapeutic potential against D816V-expressing malignancies.Src/Abl inhibitors are compatible with imatinib and suggest that combined Abl inhibitor therapy is a feasible treatment strategy for patients with CML.	price>
R-R-2214	STF-62247 CAS No.315702-99-9	STF-62247/CAS No.315702-99-9 is an autophagy inducer that selectively cytotoxic to VHL-deficient renal cell carcinoma (IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively).	price>
R-C-515	TAK285 CAS：871026-44-7	TAK-285 is a potent,selective,ATP-competitive and orally active HER2 and EGFR(HER1)inhibitor with IC50 of 17 nM and 23 nM,respectively.TAK-285 is >10-fold selectivity for HER1/2 than HER4,and less potent to MEK1/5,c-Met,Aurora B,Lck,CSK etc.TAK-285 has effective antitumor activity.TAK-285 can cross the blood-brain barrier(BBB).	price>
R-R-2215	Notoginsenoside Fc CAS No.88122-52-5	Notoginsenoside Fc/CAS No.88122-52-5, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy.	price>
R-C-516	ARN-509 cas:956104-40-8	ARN-509 is an androgen receptor antagonist with potential antineoplastic activity.ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus.This prevents binding to and transcription of AR-responsive genes.	price>
R-R-2216	AS1842856 CAS No.836620-48-5	AS1842856/CAS No.836620-48-5, a specific inhibitor of Foxo1 (IC50=30 nM), potently suppresses autophagy. AS1842856 inhibits FoxO1 activity by suppressing SIRT1 expression. AS1842856 only reduces FoxO1 activity by binding to it, without affecting its transcription and protein expression.	price>
R-C-517	OC000459 cas:851723-84-7	Timapiprant (OC000459) is a potent,selective,and orally active D prostanoid receptor 2 (DP2,also known as CRTH2) antagonist.Timapiprant (OC000459)potently displaces [3H] PGD2 from human recombinant DP2(Ki=13 nM),rat recombinant DP2(Ki=3 nM),and human native DP2(Ki=4 nM).Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils.	price>
R-R-2217	(Rac)-BL-918 CAS No.2435589-07-2	(Rac)-BL-918/CAS No.2435589-07-2 is the racemate of BL-918. BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1), inducing cytoprotective autophagy for Parkinsonism disease treatment.	price>
R-C-518	HQL-79 cas:162641-16-9	HQL-79 is a selective inhibitor of hematopoietic prostaglandin D (PGD) synthase, that structurally is a synthetic tetrazole compound originally prepared as a possible antihistamine.	price>
R-R-2218	Metformin CAS No.657-24-9	Metformin (1,1-Dimethylbiguanide)/CAS No.657-24-9 inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin can cross the blood-brain barrier and triggers autophagy.	price>
R-C-519	JTT-705 (Dalcetrapib) cas:211513-37-0	JTT-705(Dalcetrapib) is a CETP inhibitor.Inhibition of CETP is a target to increase HDL-cholesterol and potentially reduce atherosclerosis.	price>
R-R-2219	3,4-Dimethoxychalcone CAS No.5416-71-7	3,4-Dimethoxychalcone/CAS No.5416-71-7 is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research.	price>
R-C-520	MK-5108(VX689) cas:1010085-13-8	MK-5108(VX-689)is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C,while it inhibits TrkA with less than 100-fold selectivity.MK-5108 (VX-689) induces autophagy.	price>

431432433434435436 437438439440441