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Catalog	name	Description	price
R-R-2220	Desethyl chloroquine-d4 CAS No.1189971-72-9	Desethyl chloroquine-d4/CAS No.1189971-72-9 is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.	price>
R-C-521	LY2811376 cas:1194044-20-6	LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM,that act to decrease Aβ secretion with EC50 of 300 nM,demonstrated to have 10-fold selectivity towards BACE1 over BACE2,and more than 50-fold inhibition over other aspartic proteases including cathepsin D,pepsin, or renin.	price>
R-R-2221	ALLO-1 CAS No.37468-32-9	ALLO-1/CAS No.37468-32-9, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif.	price>
R-C-522	CTEP (RO4956371) CAS:871362-31-1	CTEP(RO4956371)is a novel,long-acting,orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM,shows >1000-fold selectivity over other mGlu receptors.	price>
R-R-2222	FeTMPyP CAS No.133314-07-5	FeTMPyP/CAS No.133314-07-5 is an orally active peroxynitrite (ONOO?) scavenger. FeTMPyP reduces nitrative stress and increases autophagy. FeTMPyP reduces PARP over-activation and neuroinflammation in chronic constriction injury (CCI)-induced rats, and ameliorates functional, behavioral and biochemical deficits.	price>
R-C-523	PF-02341066 cas:877399-52-5	Crizotinib(PF-02341066)is an orally bioavailable,ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively.Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays,respectively.Crizotinib is also a ROS1 inhibitor.Crizotinib has effective tumor growth inhibition.	price>
R-R-2223	Chelerythrine chloride CAS No.3895-92-9	Chelerythrine chloride/CAS No.3895-92-9 is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.	price>
R-C-524	Vonoprazan Fumarate (TAK-438)	Vonoprazan Fumarate (TAK-438) is a novel P-CAB(potassium-competitive acid blocker)that reversibly inhibits H+/K+,ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion.	price>
R-R-2224	Retro-2 CAS No.1201652-50-7	Retro-2/CAS No.1201652-50-7 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy.	price>
R-C-525	Nedocromil cas:69049-73-6	Nedocromil suppresses the action or formation of multiple mediators,including histamine,leukotriene C4 (LTC4),and prostaglandin D2(PGD2).	price>
R-R-2225	Onjisaponin B CAS No.35906-36-6	Onjisaponin B/CAS No.35906-36-6 is a natural product derived from Polygala tenuifolia. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease.	price>
R-C-526	IOX2 cas:931398-72-0	IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2(PHD2) with IC50 of 21 nM in a cell-free assay,100-fold selectivity over JMJD2A,JMJD2C,JMJD2E,JMJD3,or the 2OG oxygenase FIH.	price>
R-R-2226	Ambroxol CAS No.18683-91-5	Ambroxol (NA-872)/CAS No.18683-91-5, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.	price>
R-C-527	GNF-2 cas:778270-11-4	GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl,shows no activity to Flt3-ITD,Tel-PDGFR,TPR-MET and Tel-JAK1 transformed tumor cells.	price>
R-R-2227	Ambroxol hydrochloride CAS No.23828-92-4	Ambroxol hydrochloride (NA-872 hydrochloride)/CAS No.23828-92-4, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.	price>
R-C-528	THIACETAZONE cas:104-06-3	Thiabendazole inhibits the mitochondrial helminth-specific enzyme,fumarate reductase,with anthelminthic property,used as an anthelmintic and fungicide agent. It is a potent inhibitor of cytochrome P450 1A2 (CYP1A2).	price>
R-R-2228	Phellodendrine chloride CAS No.104112-82-5	Phellodendrine chloride/CAS No.104112-82-5 is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis . Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis.	price>
R-C-529	PD0325901 cas:391210-10-9	Mirdametinib(PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays,roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2.	price>
R-R-2229	Olaparib-d8	Olaparib-d8 is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator.	price>
R-C-530	R406 cas:841290-80-0	R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM,potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM,measured at an ATP concentration corresponding to its Km value.R406 reduces immune complex-mediated inflammation.R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).	price>

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