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Catalog	name	Description	price
R-R-2176	Atg4B-IN-2 CAS No.2765008-88-4	Atg4B-IN-2/CAS No.2765008-88-4 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition.	price>
R-C-477	MGCD0103 CAS:726169-73-9	MGCD0103(Mocetinostat)is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1(HDAC1),but also HDAC2,HDAC3,and HDAC11.It is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2-to10-fold selectivity against HDAC2,3,and 11,and no activity to HDAC4,5,6,7,and 8.Mocetinostat (MGCD0103) induces apoptosis and autophagy.	price>
R-R-2177	P62-mediated mitophagy inducer CAS No.1809031-84-2	P62-mediated mitophagy inducer (PMI)/CAS No.1809031-84-2 is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential.	price>
R-C-478	Foretinib(XL880) CAS:849217-64-7	Foretinib(GSK1363089,EXEL-2880,XL-880) is an ATP-competitive inhibitor of HGFR and VEGFR,mostly for Met (c-Met)and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays.Less potent against Ron,Flt-1/3/4,Kit (c-Kit), PDGFRα/β and Tie-2,and little activity to FGFR1 and EGFR.	price>
R-R-2178	HDAC10-IN-1	HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.	price>
R-C-479	Glesatinib(MGCD265) CAS:875337-44-3	MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs,including the c-Met receptor (HGFR);the Tek/Tie-2 receptor;VEGFR types 1,2,and 3;and MST1R.	price>
R-R-2179	HDAC10-IN-2 hydrochloride	HDAC10-IN-2 hydrochloride (compound 10c) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. HDAC10-IN-2 hydrochloride modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.	price>
R-C-480	Roscovitine (Seliciclib) CAS:186692-46-6	Roscovitine (Seliciclib,CYC202) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM,0.7 μM and 0.16 μM in cell-free assays.It shows little effect on CDK4/6.	price>
R-R-2180	Daurisoline CAS No.70553-76-3	Daurisoline/CAS No.70553-76-3 is a hERG inhibitor and also an autophagy blocker.	price>
R-C-481	sns032 CAS:345627-80-7	SNS-032(BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10-and 20-fold selective over CDK1/CDK4.It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6.SNS-032 (BMS-387032) induces apoptosi.	price>
R-R-2181	Thonningianin B CAS No.271579-12-5	Thonningianin B/CAS No.271579-12-5 is an antioxidant and an autophagy enhancer.	price>
R-C-482	ABT-263(Navitoclax) CAS:923564-51-6	ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki of <1 nmol/L for Bcl-2,Bcl-xL,and Bcl-w).it maintains a high affinity for Bcl-xL,Bcl-2,and Bcl-w,(Ki ≤1 nmol/L),but binds more weakly to Mcl-1 and A1.	price>
R-R-2182	Tat-beclin 1 CAS No.1423821-88-8	Tat-beclin 1/CAS No.1423821-88-8, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).	price>
R-C-483	ABT-737 cas:852808-04-9	ABT-737 is a pan-Bcl-2 inhibitor.IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10μM (Nalm-6,K562 and HL-60).	price>
R-R-2183	Metformin-d6 hydrochloride CAS No.1185166-01-1	Metformin-d6 (hydrochloride)/CAS No.1185166-01-1 is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy.	price>
R-C-484	NVP-BGJ398 cas:872511-34-7	Infigratinib(BGJ-398; NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM,1.4 nM,1 nM,and 60 nM for FGFR1,FGFR2,FGFR3,and FGFR4, respectively.	price>
R-R-2184	Pennogenin 3-O-beta-chacotrioside CAS No.55916-52-4	Pennogenin 3-O-beta-chacotrioside/CAS No.55916-52-4 is an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. Anti-colorectal cancer activity.	price>
R-C-485	BAY73-4506(Regorafenib) cas:755037-03-7	Regorafenib (BAY73-4506,Fluoro-Sorafenib,Resihance,Stivarga) is a multi-target inhibitor for VEGFR1,VEGFR2,VEGFR3,PDGFRβ,Kit (c-Kit),RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM,22 nM,7nM,1.5 nM and 2.5 nM in cell-free assays,respectively.Regorafenib induces autophag.	price>
R-R-2185	Aumitin CAS No.946293-78-3	Aumitin/CAS No.946293-78-3 is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively.	price>
R-C-486	Roflumilast,Daxas cas:162401-32-3	Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7,0.9,0.7,and 0.2 nM for PDE4A1,PDEA4,PDEB1,and PDEB2,respectively,without affecting PDE1,PDE2, PDE3 or PDE5 isoenzymes from various cells.	price>

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