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Catalog	name	Description	price
R-R-2230	Spironolactone-d7	Spironolactone-d7 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes.	price>
R-C-531	AT-406 cas:1071992-99-8	AT406(SM-406,ARRY-334543, Debio1143) is a potent Smac mimetic and an antagonist of IAP(inhibitor of apoptosis protein via E3 ubiquitin ligase),binding to XIAP-BIR3,cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM,1.9 nM,and 5.1 nM,50-to 100-fold higher affinities than the Smac AVPI peptide.	price>
R-R-2231	TFEB activator 1 CAS No.39777-61-2	TFEB activator 1/CAS No.39777-61-2 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment.	price>
R-C-532	R547 cas:741713-40-6	R547 is a novel,selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs)(Ki = 1,3,and 1 nM for CDK1,CDK2,and CDK4,respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.	price>
R-R-2232	Dorsomorphin dihydrochloride CAS No.1219168-18-9	Dorsomorphin dihydrochloride (BML-275 dihydrochloride; Compound C dihydrochloride)/CAS No.1219168-18-9 is an AMPK inhibitor that is potent, selective, and ATP-competitive, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits the BMP pathway by targeting the type I receptors ALK2, ALK3 and ALK6. Dorsomorphin dihydrochloride induces autophagy.	price>
R-C-533	CB-7598 cas:154229-19-3	Abiraterone(CB-7598) inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1),an enzyme which is expressed in testicular,adrenal, and prostatic tumor tissues.	price>
R-R-2233	Typhaneoside CAS No.104472-68-6	Typhaneoside/CAS No.104472-68-6, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function.	price>
R-C-534	Abiraterone Acetate(CB7630) cas:154229-18-2	Abiraterone acetate (CB7630) is an oral,potent,selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity.Abiraterone acetate is a prodrug form of Abiraterone (CB7598).	price>
R-R-2234	Olaparib-d4-1 CAS No.2143107-55-3	Olaparib-d4-1/CAS No.2143107-55-3 is the deuterium labeled Olaparib. Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator.	price>
R-C-535	R788 cas:901119-35-5	R788(Fostamatinib)is an important spleen tyrosine kinase(Syk)inhibitor,showing efficacy against kinase-mediated IgG Fc gamma receptor signaling.	price>
R-R-2235	QX77 CAS No.1798331-92-6	QX77/CAS No.1798331-92-6 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 can impede self-renewal and promote differentiation of ES cells.	price>
R-C-536	VU0364439 cas:1246086-78-1	VU0364439 is a positive allosteric modulator(PAM)of mGlu4 receptors(EC50=19.8 nM in vitro for human mGlu4).	price>
R-R-2236	Chloroquine CAS No.54-05-7	Chloroquine/CAS No.54-05-7 is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).	price>
R-C-537	TDZD-8 cas:7036-89-5	TDZD-8 is an inhibitor of GSK-3β,with an IC50 of 2 μM;TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II,PKA,and PKC,with all IC50s of >100 μM.	price>
R-R-2237	Ambroxol-d5 hydrochloride CAS No.2741380-71-0	Ambroxol-d5 (hydrochloride)/CAS No.2741380-71-0 is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.	price>
R-C-538	VU0361737 cas:1161205-04-4	VU 0361737 is a selective positive allosteric modulator(PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors,respectively,displays weak activity at mGlu5 and mGlu8 receptors,is inactive at mGlu1,mGlu2,mGlu3,mGlu6 and mGlu7 receptors,can penetrate into CNS.	price>
R-R-2238	N6-Isopentenyladenosine CAS No.7724-76-7	N6-Isopentenyladenosine (Riboprine)/CAS No.7724-76-7, an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with an interesting anti-melanoma activity.	price>
R-C-539	TCS PIM-1 4a CAS: 438190-29-5	TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor(IC50 values=24 and 100 nM for Pim-1 and Pim-2,respectively).	price>
R-R-2239	Taurine-13C2 CAS No.70155-54-3	Taurine-13C2/CAS No.70155-54-3 is the 13C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.	price>
R-C-540	YS-49 cas:132836-42-1	YS-49 is a PI3K/Akt(a downstream target of RhoA)activator,to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells.YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1.YS-49 is also an isoquinoline compound alkaloid,has a strong positive inotropic action through activation of cardiac β-adrenoceptors.	price>

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