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Catalog	name	Description	price
R-R-2240	Fascaplysin CAS No.114719-57-2	Fascaplysin/CAS No.114719-57-2 is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.	price>
R-C-541	YM-90K hydrochloride cas:154164-30-4	YM90K hydrochloride is an antagonist of AMPA receptor.	price>
R-R-2241	PHY34 CAS No.2130033-55-3	PHY34/CAS No.2130033-55-3 is an inhibitor that inhibits ATP6V0A2 and CAS thereby inhibiting autophagy, and has a nanomolar effect. PHY34 inhibits cancer cell growth by inducing apoptosis and inhibits tumor growth in xenograft models. PHY34 can be used for research on high grade serous ovarian cancer.	price>
R-C-542	Tiplaxtinin (PAI-039) CAS 393105-53-8	Tiplaxtinin(PAI-039)is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1(PAI-1) with IC50 of 2.7 uM.	price>
R-R-2242	Dorsomorphin CAS No.866405-64-3	Dorsomorphin (Compound C)/CAS No.866405-64-3 is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).	price>
R-C-543	Dapivirine (TMC120) CAS 244767-67-7	Dapivirine(TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM,inhibits a broad panel of HIV-1 isolates from different classes,inclucing a wide range of NNRTI-resistant isolates.	price>
R-R-2243	SAR405 CAS No.1523406-39-4	SAR405/CAS No.1523406-39-4 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity.	price>
R-C-544	WZ 811 CAS 55778-02-4	WZ811 is an orally active, highly potent competitive antagonist of CXCR4.WZ811 efficiently inhibits CXCR4/SDF-1(or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM).	price>
R-R-2244	Wortmannin CAS No.19545-26-7	Wortmannin (SL-2052; KY-12420)/CAS No.19545-26-7 is a potent, selective, and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50 of 5.8 and 48 nM, respectively.	price>
R-C-545	TTP 22 CAS 329907-28-0	TTP 22 is a high affinity,ATP-competitive casein kinase 2(CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity >250-fold for CK2 over JNK3,ROCK1, and MET(IC50> 10 uM).	price>
R-R-2245	Felodipine-d3 CAS No.1219795-30-8	Felodipine-d3/CAS No.1219795-30-8 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.	price>
R-C-546	AG-490 CAS: 134036-52-5	AG-490(Tyrphostin AG 490) is an inhibitor of EGFR (IC50: 0.1μM).It is 135-fold more selective for EGFR than ErbB2,also inhibits JAK2 with no effect to Lyn,Lck, Syk,Btk,and Src.	price>
R-R-2246	Ethyl pyruvate CAS No.617-35-6	Ethyl pyruvate/CAS No.617-35-6 is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity.	price>
R-R-2247	Felodipine-d5 CAS No.1242281-38-4	Felodipine-d5/CAS No.1242281-38-4 is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.	price>
R-C-548	DY131 CAS: 95167-41-2	DY131(GSK 9089) is a potent and selective ERRγ and ERRβ agonist.DY131displays inactive against ERRα,ERα and ERβ.DY131 also inhibits Smo signaling.	price>
R-R-2248	FDW028 CAS No.2768426-49-7	FDW028/CAS No.2768426-49-7 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research.	price>
R-C-549	GW788388 CAS: 452342-67-5	GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell-free assay,also inhibits TGF-βtype II receptor and activin type II receptor activities,but does not inhibit BMP type II receptor.	price>
R-R-2249	Brefeldin A CAS No.20350-15-6	Brefeldin A (BFA)/CAS No.20350-15-6 is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from the endoplasmic reticulum to the Golgi apparatus. Brefeldin A is also an inhibitor of autophagy and mitophagy. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity.	price>
R-C-550	Pyridone 6 CAS:457081-03-7	Pyridone 6(CMP 6)is a potent and selective inhibitor of JAK1 (IC50=15 nM,murine JAK1),JAK2 (IC50=1 nM),JAK3 (Ki=5 nM),and Tyk2 (IC50=1 nM);displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.	price>
R-R-2250	Everolimus-d4 CAS No.1338452-54-2	Everolimus-d4/CAS No.1338452-54-2 is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities.	price>

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