Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-C-551	(NSC 42834)JAK2 Inhibitor V Z3 CAS :195371-52-9	NSC 42834(JAK2 Inhibitor V,Z3) is a novel specific inhibitor of Jak2,inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.	price>
R-R-2251	EIPA hydrochloride CAS No.1345839-28-2	EIPA hydrochloride (L593754 hydrochloride)/CAS No.1345839-28-2 is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also inhibits Na+/H+ exchangers (NHE) and macropinocytosis.	price>
R-C-552	KU14R CAS:189224-48-4	KU14R is a new I(3)-R antagonist,which selectively blocks the insulin secretory response to imidazolines.	price>
R-R-2252	PD146176 CAS No.4079-26-9	PD146176 (NSC168807)/CAS No.4079-26-9, a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.	price>
R-C-553	LDN-211904 CAS:1198408-39-7	A pyrazolo[1,5-a] pyridine derivative,as an effective and reversible inhibitor of EphB3 receptor tyrosine kinase,has good stability and water solubility in mouse liver microsomes with IC50 of 79 nm.EphB3 induced autophosphorylation of EphB3 receptor was inhibited in 10 μ M cells.	price>
R-R-2253	Evogliptin tartrate CAS No.1222102-51-3	Evogliptin (DA-1229) tartrate/CAS No.1222102-51-3 is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin tartrate also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin tartrate can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation.	price>
R-C-554	MK 886 CAS: 118414-82-7	MK-886 is an inhibitor of leukotriene biosynthesis,inhibiting 5-lipoxygenase-activating protein (FLAP).It is also a moderately potent PPARα antagonist.	price>
R-R-2254	Taurine-13C2,15N CAS No.2483830-42-6	Taurine-13C2,15N/CAS No.2483830-42-6 is the 13C- and 15N- labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.	price>
R-C-555	TAC-101 CAS:125973-56-0	Amsilarotene inhibits the phosphorylation of retinoblastoma gene product(RB) and increases the presence of 2 cyclin-dependent kinases(CDK)inhibitors resulting in cell cycle arrest.This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.	price>
R-R-2255	Bromhexine-d3 hydrochloride	Bromhexine-d3 (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions.	price>
R-C-556	3-Methyladenine (3-MA) cas:5142-23-4	3-Methyladenine (3-MA,NSC 66389) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells;blocks class I PI3K consistently,whereas suppression of class III PI3K is transient,and also blocks autophagosome formation.3-Methyladenine(3-MA)is successfully used to suppress mitophagy.	price>
R-R-2256	Imipramine hydrochloride CAS No.113-52-0	Imipramine hydrochloride/CAS No.113-52-0 is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects.	price>
R-C-557	PHT427 cas:1191951-57-1	PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.	price>
R-R-2257	EIPA CAS No.1154-25-2	EIPA (L593754)/CAS No.1154-25-2 is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+ exchangers (NHE) and macropinocytosis.	price>
R-C-558	GW7647 cas:265129-71-3	GW7647 is a potent PPARαagonist,with EC50s of 6 nM,1.1μM,and 6.2μM for human PPARα,PPARγ and PPARδ,respectively.	price>
R-R-2258	Dasatinib monohydrate CAS No.863127-77-9	Dasatinib (BMS-354825) monohydrate/CAS No.863127-77-9 is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib monohydrate also induces apoptosis and autophagy.	price>
R-C-559	LY364947 cas:396129-53-6	LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM,and exhibits 7-fold selectivity over TGFβR-II.	price>
R-R-2259	SB 202190 hydrochloride CAS No.350228-36-3	SB 202190 hydrochloride/CAS No.350228-36-3 is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity. SB202190 hydrochloride induces autophagy.	price>
R-C-560	SB203580 cas:152121-47-6	SB203580(RWJ 64809)is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively.SB 203580 inhibits LCK,GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38.SB 203580 does not disrupt JNK activity and is an autophagy and mitophagy activator.	price>
R-R-2260	LYN-1604 dihydrochloride CAS No.2310109-38-5	LYN-1604 dihydrochloride/CAS No.2310109-38-5 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).	price>

435436437438439440 441442443444445