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Catalog	name	Description	price
R-C-561	ZM323881 cas:324077-30-7	ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC50=8 nM) and VEGF-R2 tyrosine phosphorylation(IC50Vascular endothelial growth factor(VEGF) increases vascular permeability and angiogenesis in many pathological conditions, such as cancer,arthritis,and diabetes.VEGF activates VEGF-Receptor 1(VEGF-R1)and VEGF-Receptor 2(VEGF-R2)that autophosphorylate to initiate a signaling cascade resulting in angiogenesis and increased microvascular permeability.ZM323881 is a potent and selective inhibitor of VEGF-R2 tyrosine kinase.	price>
R-R-2261	Pemetrexed CAS No.137281-23-3	Pemetrexed (LY231514)/CAS No.137281-23-3 is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.	price>
R-C-562	ZM306416 cas:690206-97-4	ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt,respectively.ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.	price>
R-R-2262	AG490 CAS No.133550-30-8	AG490 (Tyrphostin AG490)/CAS No.133550-30-8 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.	price>
R-C-563	PF8380 cas:1144035-53-9	Pf-8380 is an effective automatic classification inhibitor with IC (50) of 2.8 nm in isolated enzyme assay and 101 nm in human blood.	price>
R-R-2263	Coumermycin A1 CAS No.4434-05-3	Coumermycin A1/CAS No.4434-05-3 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.	price>
R-C-564	RITA (NSC 652287) cas:213261-59-7	RITA(NSC 652287)induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks,and also inhibits MDM2-p53 interaction by targeting p53.	price>
R-R-2264	SJ1008030 TFA CAS No.2863634-97-1	SJ1008030 (compound 8) TFA/CAS No.2863634-97-1 is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 TFA inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 TFA can be used for the research of leukemia.	price>
R-C-565	ACY-1215 cas:1316214-52-4	Ricolinostat (ACY-1215,Rocilinostat)is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay.It is>10-fold more selective for HDAC6 than HDAC1/2/3(class I HDACs)with slight activity against HDAC8,minimal activity against HDAC4/5/7/9/11,Sirtuin1,and Sirtuin2.Ricolinostat (ACY-1215)suppresses cell proliferation and promotes apoptosis.	price>
R-R-2265	Ruxolitinib phosphate CAS No.1092939-17-7	Ruxolitinib phosphate (INCB018424 phosphate)/CAS No.1092939-17-7 is a potent JAK1/2 inhibitor with IC50s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3.	price>
R-C-566	ASP3026 cas:1097917-15-1	ASP3026 is a potent,selective and orally active inhibitor of anaplastic lymphoma kinase(ALK).ASP3026 induces apoptosis of tumor cells.ASP3026 can be used for the research of non-small cell lung cancer (NSCLC).	price>
R-R-2266	Ritlecitinib CAS No.1792180-81-4	Ritlecitinib/PF-06651600/CAS No.1792180-81-4 is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM.	price>
R-C-567	sch900776 cas:891494-63-6	SCH900776(MK-8776) is a potent,selective and orally bioavailable inhibitor of checkpoint kinase1(Chk1) with an IC50 of 3 nM.SCH900776 shows 50-and 500-fold selectivity over CDK2 and Chk2,respectively.	price>
R-R-2267	Butyzamide CAS No.1110767-45-7	Butyzamide/CAS No.1110767-45-7 is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay.	price>
R-C-568	CP-945598 cas:686347-12-6	Otenabant(CP-945598) HCl is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM,exhibits 10,000-fold greater selectivity against human CB2 receptor.	price>
R-R-2268	RO8191 CAS No.691868-88-9	RO8191 (CDM-3008)/CAS No.691868-88-9, an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity.	price>
R-C-569	OSI-027 cas:936890-98-1	OSI-027(ASP4786)is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα,PI3Kβ,PI3Kγ or DNA-PK.OSI-027 induces autophagy in cancer cells.	price>
R-R-2269	CHZ868 CAS No.1895895-38-1	CHZ868/CAS No.1895895-38-1 is a type II JAK2 inhibitor with an IC50 of 0.17 μM in EPOR JAK2 WT Ba/F3 cell.	price>
R-C-570	SB431542 cas:301836-41-9	SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I ALK receptors ALK4,ALK5,and ALK7.	price>
R-R-2270	JAK2 JH2 Tracer CAS No.2101955-00-2	JAK2 JH2 Tracer (Tracer 5)/CAS No.2101955-00-2 is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM.	price>

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