Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-C-571	Tenovin-1 cas:380315-80-0	Tenovin-1,a p53 activator,protects p53 from MDM2-mediated degradation.Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase(DHODH)inhibitor.	price>
R-R-2271	Baricitinib phosphate CAS No.1187595-84-1	Baricitinib phosphate (LY3009104 phosphate; INCB028050 phosphate)/CAS No.1187595-84-1 is a selective orally bioavailable JAK1/JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, respectively.	price>
R-C-572	Apoptosis Activator 2 cas:79183-19-0	Apoptosis Activator 2 strongly induces caspase-3 activation,PARP cleavage,and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM,inactive to HMEC,PREC,or MCF-10A cells.	price>
R-R-2272	Atractylenolide I CAS No.73069-13-3	Atractylenolide I/CAS No.73069-13-3 is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.	price>
R-C-573	HA14-1 cas:65673-63-4	HA14-1 is a small,cell-permeable nonpeptidic ligand that binds to the Bcl-2 surface pocket and blocks its biological action.HA14-1 induces apoptosis in HL-60 leukemic cells overexpressing Bcl-2 and in NIH 3T3 cells via the activation of caspases by a mechanism that is distinct from Fas-mediated apoptosis.	price>
R-R-2273	Zasocitinib CAS No.2272904-53-5	Zasocitinib (NDI-034858)/CAS No.2272904-53-5 is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM.	price>
R-C-574	SMI-4a cas:327033-36-3	SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK.Mostly potent to Pim-2,does not significantly inhibit any other serine/threonine-or tyrosine-kinases.	price>
R-R-2274	Delgocitinib CAS No.1263774-59-9	Delgocitinib (JTE-052)/CAS No.1263774-59-9 is a specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.	price>
R-C-575	Emtricitabine cas:143491-57-0	Emtricitabine is a nucleoside reverse transcriptase inhibitor(NRTI) with an EC50 of 0.01 µM in PBMC cell.It is an antiviral drug for the treatment of HIV infection.	price>
R-R-2275	Decernotinib CAS No.944842-54-0	Decernotinib/CAS No.944842-54-0 is a potent, orally active JAK3 inhibitor, with Kis of 2.5, 11, 13 and 11 nM for JAK3, JAK1, JAK2, and TYK2, respectively.	price>
R-C-576	TWS119 cas:601514-19-6	TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay;capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3β inhibition triggers autophagy.	price>
R-R-2276	Oclacitinib maleate CAS No.1640292-55-2	Oclacitinib maleate (PF-03394197 maleate)/CAS No.1640292-55-2 is a novel JAK inhibitor. Oclacitinib maleate (PF-03394197 maleate) is most potent at inhibiting JAK1 (IC50=10 nM).	price>
R-C-577	VU 0364439 cas:1246086-78-1	VU 0364439 is a positive allosteric modulator(PAM)of mGlu4 receptors(EC50=19.8 nM in vitro for human mGlu4).	price>
R-R-2277	Ruxolitinib (S enantiomer) CAS No.941685-37-6	Ruxolitinib (S enantiomer) (S-Ruxolitinib)/CAS No.941685-37-6 is the S-enantiomer of Ruxolitinib (HY-50856). Ruxolitinib (S enantiomer) is an orally active, potent JAK inhibitor.	price>
R-C-578	LY315920 cas:172732-68-2	LY315920(Varespladib)is a potent and selective secretory phospholipase A2 (sPLA) inhibitor with IC50 of 7 nM.In BAL cells challenged with human sPLA2,LY315920 at doses ranging from 0.1 μM–3μM reduces the formation of thromboxane mediated by human sPLA2 in a concentration-dependent manner with an IC50 of approximately 0.8 μM.	price>
R-R-2278	AZ960 CAS No.905586-69-8	AZ960/CAS No.905586-69-8 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM.	price>
R-C-579	Anamorelin cas:249921-19-5	Anamorelin is currently under development for the management of non-small lung cancer associated cachexia/anorexia.	price>
R-R-2279	Brepocitinib P-Tosylate CAS No.2140301-96-6	Brepocitinib (PF-06700841) P-Tosylate/CAS No.2140301-96-6 is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib P-Tosylate also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively.	price>
R-C-580	Vistusertib (AZD2014) CAS:1009298-59-2	AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.mTOR kinase inhibitor.	price>
R-R-2280	BMS-986202 CAS No.1771691-34-9	BMS-986202/CAS No.1771691-34-9 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 value of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium.	price>

437438439440441442 443444445446447