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Catalog	name	Description	price
R-C-581	LY2940680 cas:1258861-20-9	Taladegib(LY2940680)binds to the Smoothened(Smo)receptor and potently inhibits Hedgehog(Hh)signaling.	price>
R-R-2281	Izencitinib CAS No.2051918-33-1	Izencitinib (TD-1473)/CAS No.2051918-33-1 is an orally active, non-selective and gut-restricted JAK inhibitor. Izencitinib (TD-1473) can be used in the study for ulcerative colitis.	price>
R-C-582	LY500307 cas:533884-09-2	Erteberel(LY500307)is a potent and selective estrogen receptor beta(ERβ)agonist with Ki and EC50 of 1.54 nM and 3.61 nM,respectively.Anti-tumor activities.	price>
R-R-2282	Golidocitinib CAS No.2091134-68-6	AZD4205/CAS No.2091134-68-6 is a selective inhibitor of JAK1, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM).	price>
R-C-583	LY2608204 cas:1234703-40-2	LY2608204 is a potent used to treat type 2 diabetes.In a clinical trial,a study was performed to evaluate the safety and tolerability of LY2608204 in patients with type 2 diabetes.	price>
R-R-2283	Ilginatinib CAS No.1239358-86-1	Ilginatinib (NS-018)/CAS No.1239358-86-1 is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).	price>
R-C-584	TAK-700 (Orteronel) cas:566939-85-3	TAK-700(Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM,exhibits >1000-fold selectivity over other CYPs (e.g.11-hydroxylase and CYP3A4).TAK-700(Orteronel) is an androgen biosynthesis inhibitor.	price>
R-R-2284	(Z)-LFM-A13 CAS No.244240-24-2	LFM-A13/CAS No.244240-24-2 is a potent BTK, JAK2, PLK inhibitor, inhibits recombinant BTK, Plx1 and PLK3 with IC50s of 2.5 μM, 10 μM and 61 μM; LFM-A13 shows no effects on JAK1 and JAK3, Src family kinase HCK, EGFR and IRK.	price>
R-C-585	Linagliptin(BI-1356) cas:668270-12-0	Linagliptin (BI-1356) is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8,and DPP-9.Linagliptin activates glomerular autophagy in a model of type 2 diabetes.DPP4 mediates ferroptosis in TP53-deficient CRC cells.	price>
R-R-2285	Solcitinib CAS No.1206163-45-2	Solcitinib/CAS No.1206163-45-2 is an orally active, competitive, potent, selective JAK1 inhibitor, with an IC50 of 9.8 nM, and 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively; Solcitinib is used in the research of moderate-to-severe plaque-type psoriasis.	price>
R-C-586	NVP-BHG712 cas:940310-85-0	NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf,c-Src and c-Abl with IC50 of 0.395 μM,1.266 μM and 1.667 μM,respectively.	price>
R-R-2286	Gusacitinib CAS No.1425381-60-7	Gusacitinib (ASN-002)/CAS No.1425381-60-7 is a dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) that is orally active and potent with IC50 values of 5-46 nM. Gusacitinib has anticancer activity in both solid and hematologic tumor types.	price>
R-C-587	Amrubicin cas:110267-81-7	Amrubicin is a synthetic anthracycline antibiotic.It inhibits DNA topoisomerase II. Antineoplastic.	price>
R-R-2287	Tyk2-IN-5 CAS No.1797432-62-2	Tyk2-IN-5 (compound 6)/CAS No.1797432-62-2 is a potent, selective and orally active tyrosine kinase 2 (Tyk2) inhibitor that acts on the JH2 structural domain. Tyk2-IN-5 shows a Ki value of 0.086 nM for Tyk2 JH2 and an IC50 value of 25 nM for IFNα. Tyk2-IN-5 efficiently inhibits the production of IFNγ in a pharmacodynamic rat model and is fully efficacious in a rat model of arthritis.	price>
R-C-588	WAY362450 cas:629664-81-9	WAY-362450 is a highly potent, selective,and orally bioavailable farnesoid X receptor(FXR)agonist (EC50:4 nM,eff=149%).	price>
R-R-2288	Momelotinib sulfate CAS No.1056636-06-6	Momelotinib sulfate (CYT387 sulfate salt)/CAS No.1056636-06-6 is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, 10-fold selectivity versus JAK3 (IC50=155 nM).	price>
R-C-589	AZD8931 cas:848942-61-0	Sapitinib(AZD8931)is a reversible,ATP competitive inhibitor of EGFR,ErbB2 and ErbB3 with IC50 of 4 nM,3 nM and 4 nM in cell-free assays,more potent than Gefitinib or Lapatinib against NSCLC cell,100-fold more selective for the ErbB family than MNK1 and Flt.	price>
R-R-2289	VVD-118313 CAS No.2875046-27-6	VVD-118313 (compound 5a)/CAS No.2875046-27-6 is a potent, selective JAK1 inhibitor. VVD-118313 targets an isoform-restricted allosteric cysteine to block JAK1-dependent trans-phosphorylation and cytokine signaling. VVD-118313 can be used for research of cancer. VVD-118313 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-590	Dabigatran etexilate cas:872728-81-9	Dabigatran etexilate(BIBR 1048)is an orally active prodrug of Dabigatran. Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.	price>
R-R-2290	BD750 CAS No.892686-59-8	BD750/CAS No.892686-59-8, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively.	price>

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