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Catalog	name	Description	price
R-C-591	Lersivirine（UK 453061） cas:473921-12-9	Lersivirine(UK-453,061)is a next-generation nonnucleoside reverse transcriptase inhibitor,active against wild-type HIV-1 and several nonnucleoside reverse transcriptase inhibitor-resistant strains.	price>
R-R-2291	Povorcitinib CAS No.1637677-22-5	Povorcitinib (INCB54707)/CAS No.1637677-22-5 is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib is used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) (information extracted from patent WO2021076124A1).	price>
R-R-2292	JAK2-IN-6 CAS No.353512-04-6	JAK2-IN-6/CAS No.353512-04-6, a multiple-substituted aminothiazole derivative, is a potent and selective JAK2 inhibitor with an IC50 of 22.86 μg/mL. JAK2-IN-6 shows no activity against JAK1 and JAK3. JAK2-IN-6 has anti-proliferative effect against cancer cells.	price>
R-C-593	Pictilisib (GDC-0941) cas:957054-30-7	Pictilisib (GDC-0941,RG7321) is a potent inhibitor of PI3Kα/δwith IC50 of 3 nM in cell-free assays,with modest selectivity against p110β(11-fold) and p110γ(25-fold).Pictilisib (GDC-0941) induces autophagy and apoptosis.	price>
R-R-2293	Broussonin E CAS No.90902-21-9	Broussonin E/CAS No.90902-21-9 is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis.	price>
R-C-594	ABT-199 cas:1257044-40-8	Venetoclax (ABT-199,GDC-0199)is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays,4800-fold more selective versus Bcl-xL and Bcl-w,and no activity to Mcl-1.Venetoclax is reported to induce cell growth suppression,apoptosis,cell cycle arrest,and autophagy in triple negative breast cancer MDA-MB-231 cells.	price>
R-R-2294	Itacnosertib CAS No.1628870-27-8	Itacnosertib (TP-0184)/CAS No.1628870-27-8 is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871.	price>
R-C-595	TG101348 cas:936091-26-8	Fedratinib(SAR302503,TG101348)is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays,35-and 334-fold more selective for JAK2 versus JAK1 and JAK3.Fedratinib also inhibits FMS-like tyrosine kinase 3(FLT3)and RET (c-RET)with IC50 of 15 nM and 48 nM,respectively. Fedratinib has potential antineoplastic activity.Fedratinib inhibits proliferation and induces apoptosis.	price>
R-R-2295	TyK2-IN-2 CAS No.2098466-94-3	TyK2-IN-2 (Compoud 18)/CAS No.2098466-94-3 is a TYK2 inhibitor that is potent and selective with IC50s of 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα, respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC50 of 62 nM. TyK2-IN-2 can be used for research of inflammatory and autoimmune diseases.	price>
R-C-596	AGI-5198 cas:1355326-35-0	AGI-5198,also know as IDH-C35,is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity.	price>
R-R-2296	SJ10542 CAS No.2789678-92-6	SJ10542/CAS No.2789678-92-6 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter.	price>
R-C-597	XL647 cas:781613-23-8	XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization,including EGFR,HER2,ERBB2,VEGFR and EphB4.	price>
R-R-2297	ZM39923 hydrochloride CAS No.1021868-92-7	ZM39923 hydrochloride/CAS No.1021868-92-7 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.	price>
R-C-598	Catharanthine sulfate cas:70674-90-7	Catharanthine is a natural compound isolated from Catharanthus roseus.It exhibits antitumor activity.	price>
R-R-2298	Cerdulatinib hydrochloride CAS No.1369761-01-2	Cerdulatinib hydrochloride (PRT062070)/CAS No.1369761-01-2 is a selective, oral active and reversible ATP-competitive inhibitor of dual SYK and JAK, with IC50s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for SYK and Tyk2, JAK1, 2, 3, respectively. Cerdulatinib hydrochloride could be used to research autoimmune disease and B-cell malignancies.	price>
R-C-599	Vilazodone cas:163521-12-8	Vilazodone(EMD-68843,SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity.The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine(Ki=56 nM)and dopamine (Ki=37 nM) sites.	price>
R-R-2299	DTP3 CAS No.1809784-29-9	DTP3 TFA/CAS No.1809784-29-9 is a potent and selective GADD45β/MKK7 inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.	price>
R-C-600	Celecoxib cas:169590-42-5	Celecoxib(SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.	price>
R-R-2300	Londamocitinib CAS No.2241039-81-4	Londamocitinib (AZD4604; JAK1-IN-7)/CAS No.2241039-81-4 is a Janus-associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti-inflammatory effect.	price>
R-C-601	Rabeprazole sodium cas:117976-90-6	Rabeprazole sodium (LY307640 sodium)is a second-generation proton pump inhibitor(PPI)that irreversibly inactivates gastric H+/K+-ATPase.Rabeprazole sodium induces apoptosis.Rabeprazole sodium acts as an uridine nucleoside ribohydrolase(UNH)inhibitor with an IC50 of 0.3 μM.Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux.	price>

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