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Catalog	name	Description	price
R-R-2301	Ifidancitinib CAS No.1236667-40-5	Ifidancitinib (ATI-50002)/CAS No.1236667-40-5 is a potent and selective inhibitor of JAK kinases 1/3. Ifidancitinib can be used in studies of allergies, asthma and autoimmune diseases.	price>
R-C-602	CGK733 cas:905973-89-9	CGK733,a thiourea-containing compound,was originally identified as a specific inhibitor of ATR and ATM kinases (IC50=~200 nM).In prematurely senescent breast, lung, and colon cancer cells CGK733 reportedly suppresses ATM-mediated p21 expression required for survival,resulting in cell death.	price>
R-R-2302	Protosappanin A CAS No.102036-28-2	Protosappanin A (PTA)/CAS No.102036-28-2, an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3.	price>
R-C-603	vx809 cas:936727-05-8	VX-80(Lumacaftor,VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR)maturation,EC50 of 0.1 μM in fisher rat thyroid cells.	price>
R-R-2303	Brepocitinib CAS No.1883299-62-4	Brepocitinib (PF-06700841)/CAS No.1883299-62-4 is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively.	price>
R-C-604	PR-619 cas:2645-32-1	PR-619 is a cell-permeable,reversible,and broad-spectrum inhibitor of the deubiquitinylating enzymes(DUBs).	price>
R-R-2304	TCS 21311 CAS No.1260181-14-3	TCS 21311 (NIBR3049)/CAS No.1260181-14-3 is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively.	price>
R-C-605	Belinostat cas:414864-00-9	Belinostat(PXD101,NSC726630,PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay,with activity demonstrated in cisplatin-resistant tumors.Belinostat(PXD101)induces autophagy.	price>
R-R-2305	JAK2-IN-7 CAS No.2593402-36-7	JAK2-IN-7/CAS No.2593402-36-7 is a selective JAK2 inhibitor with IC50s of 3, 11.7, and 41 nM for JAK2, SET-2, and Ba/F3V617F cells, respectively. JAK2-IN-7 possesses >14-fold selectivity over JAK1, JAK3, FLT3. JAK2-IN-7 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cellapoptosis. Antitumor activities.	price>
R-C-606	SNS-314 cas: 1146618-41-8	SNS-314 is a potent and selective inhibitor of Aurora A,Aurora B and Aurora C with IC50 of 9 nM,31 nM,and 3 nM,respectively.It is less potent to Trk A/B, Flt4,Fms,Axl,c-Raf and DDR2.	price>
R-R-2306	JAK-IN-5 hydrochloride CAS No.2751323-21-2	JAK-IN-5 hydrochloride/CAS No.2751323-21-2 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.	price>
R-C-607	QNZ (EVP4593) cas:545380-34-5	QNZ(EVP4593)shows strong inhibitory effects on NF-κB transcriptional activation and TNF-αproduction with IC50s of 11 and 7 nM,respectively.QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.	price>
R-R-2307	BI-1622 CAS No.2681392-19-6	BI-1622/CAS No.2681392-19-6 is an orally active, potent and highly selective HER2 (ERBB2) inhibitor, with an IC50 of 7 nM. BI-1622 shows greater than 25-fold selectivity over EGFR. BI-1622 shows high antitumor efficacy in vivo in xenograft mouse tumor models with engineered H2170 and PC9 cells and had a favorable agent metabolism and pharmacokinetics profile.	price>
R-C-608	SU11274 cas:658084-23-2	SU11274(PKI-SU11274)is a selective Met(c-Met)inhibitor with IC50 of 10 nM in cell-free assays,no effects on PGDFRβ,EGFR or Tie2.SU11274 induces autophagy,apoptosis and cell cycle arrest.	price>
R-R-2308	JAK2/FLT3-IN-1 TFA CAS No.2928093-29-0	JAK2/FLT3-IN-1 (TFA)/CAS No.2928093-29-0 is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 (TFA) has anti-cancer activity.	price>
R-C-609	p005672HCL cas:1035979-44-2	P5091(P005091)is a selective and potent inhibitor of ubiquitin-specific protease 7(USP7)with EC50 of 4.2 μM and the closely related USP47.	price>
R-R-2309	PF-06263276 CAS No.1421502-62-6	PF-06263276 (PF 6263276)/CAS No.1421502-62-6 is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively.	price>
R-C-610	PLX4720 cas:918505-84-7	PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay,equally potent to c-Raf-1(Y340D and Y341D mutations),10-fold selectivity for B-RafV600E than wild-type B-Raf.	price>
R-R-2310	WHI-P97 CAS No.211555-05-4	WHI-P97/CAS No.211555-05-4 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo.	price>
R-C-611	LDK378 cas:1032900-25-6	LDK378 is a highly selective,orally bioavailable and ATP-competitive small molecule inhibitor of ALK(Anaplastic Lymphoma Kinase),a receptor tyrosine kinase considered to be an important lung cancer drug target.	price>

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