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Catalog	name	Description	price
R-R-2311	SC99 CAS No.882290-02-0	SC99/CAS No.882290-02-0 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities.	price>
R-C-612	PluriSln 1 cas:91396-88-2	stearoyl-CoA desaturase 1(SCD1)inhibitor.Used to selectively eliminate undifferentiated human pluripotent stem cells(hPSCs)from culture;induces ER stress,attenuates protein synthesis and induces apoptosis in hPSCs.Prevents teratoma formation in immunocompromised mice.	price>
R-R-2312	RGB-286638 free base CAS No.784210-88-4	RGB-286638/CAS No.784210-88-4 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.	price>
R-C-613	BKM-120 cas:944396-07-0	Buparlisib(BKM120;NVP-BKM120)is a pan-class I PI3K inhibitor,with IC50s of 52,166,116 and 262 nM for p110α,p110β,p110δ and p110γ,respectively.	price>
R-R-2313	Ilginatinib hydrochloride CAS No.1239358-85-0	Ilginatinib hydrochloride (NS-018 hydrochloride)/CAS No.1239358-85-0 is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).	price>
R-C-614	Rostafuroxin(PST2238) cas:156722-18-8	Rostafuroxin(PST 2238),a digitoxigenin derivative,is an orally active and potent Na+,K+-ATPase(ATP1A1)antognist.Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus(RSV)-triggered EGFR Tyr845 phosphorylation.Rostafuroxin has antihypertensive and anti-RSV activity.	price>
R-R-2314	Tyk2-IN-7 CAS No.1609391-90-3	Tyk2-IN-7/CAS No.1609391-90-3 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model.	price>
R-C-615	unc1215 Cas:1415800-43-9	UNC1215 is a potent and selective inhibitor for the methyllysine (Kme) reading domain function of L3MBTL3 with a Kd value of 120 nM and an IC50 of 40 nM. UNC1215 has the potential to treat malignant brain tumor.	price>
R-R-2315	Itacitinib adipate CAS No.1334302-63-4	Itacitinib adipate/CAS No.1334302-63-4 is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.	price>
R-C-616	Icotinib cas:610798-31-7	Icotinib(BPI-2009H)is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR,EGFR(L858R),EGFR(L861Q),EGFR(T790M) and EGFR(T790M,L858R).	price>
R-R-2316	JAK2/FLT3-IN-1 CAS No.2387765-27-5	JAK2/FLT3-IN-1/CAS No.2387765-27-5 is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 has anti-cancer activity.	price>
R-C-617	VU0357121 cas:433967-28-3	VU 0357121 is a positive and highly selective mGlu5R allosteric modulator(PAM) with an EC50 of 33 nM.VU 0357121 is inactive or very weakly antagonizing at other mGlu receptor subtypes.	price>
R-R-2317	Lorpucitinib CAS No.2230282-02-5	Lorpucitinib/CAS No.2230282-02-5 is a Gut-Restricted JAK Inhibitor for the research of Inflammatory Bowel Disease.	price>
R-C-618	XL-147 cas:934526-89-3	Pilaralisib(XL147;SAR245408)is a potent and highly selective class I PI3Ks inhibitor with IC50s of 39 nM,383 nM,23 nM and 36 nM for PI3Kα,PI3Kβ,PI3Kγ, and PI3Kδ.	price>
R-R-2318	Ilunocitinib CAS No.1187594-14-4	Ilunocitinib (compound 27)/CAS No.1187594-14-4 is a JAK inhibitor (extracted from patent WO2009114512A1).	price>
R-C-619	PD173074 cas:219580-11-7	PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays,~1000-fold selective for FGFR1 than PDGFR and c-Src.PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells.	price>
R-R-2319	(E/Z)-Zotiraciclib hydrochloride CAS No.1321626-25-8	(E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride/CAS No.1321626-25-8 is a potent CDK2, JAK2, and FLT3 inhibitor.	price>
R-C-620	Vicriviroc Malate cas:541503-81-5	Vicriviroc maleate(SCH-417690 maleate;SCH-D maleate) is a potent,selective,oral bioavailable and CNS penetrated antagonist of CCR5,with a Ki of 2.5 nM,and also inhibits HIV-1 in PBMC cells,with IC90s of 3.3 nM (JrFL),2.8 nM (ADA-M), 1.8 nM (301657),4.9 nM (JV1083) and 10 nM (RU 570).	price>
R-R-2320	JAK1-IN-8 CAS No.1973485-18-5	JAK1-IN-8/CAS No.1973485-18-5, a potent JAK1 inhibitor (IC50<500 nM), compound 28, extracted from patent WO2016119700A1.	price>
R-C-621	Maraviroc(Selzentry, UK-427857) cas:376348-65-1	Maraviroc (UK-427857) is a CCR5 antagonist for MIP-1α,MIP-1βand RANTES with IC50 of 3.3 nM,7.2 nM and 5.2 nM in cell-free assays,respectively.Maraviroc is used in the treatment of HIV infection.	price>

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