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Catalog	name	Description	price
R-C-652	RGFP966	RGFP966 is a highly selective HDAC3 inhibitor with an IC50 of 80 nM and shows no inhibition to other HDACs at concentrations up to 15 μM.RGFP966 can penetrate the blood brain barrier(BBB).	price>
R-R-2352	JAK-IN-25 CAS No.2127110-22-7	JAK-IN-25 (compound 19)/CAS No.2127110-22-7 is a potent JAK inhibitor with IC50s of 6 nM, 21 nM, 8 nM, 1051 nM for TYK2, JAK1, JAK2, JAK3, respectively. JAK-IN-25 inhibits human whole blood IL-12 (HEB IL-12) with an IC50 of 28 nM. JAK-IN-25 has the potential for cancer research.	price>
R-C-653	AZD1080 cas:612487-72-6	AZD1080 is a novel GSK3 inhibitor,rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.	price>
R-R-2353	Lepzacitinib CAS No.2321488-47-3	Lepzacitinib/CAS No.2321488-47-3 is a Janus kinase inhibitor targeting to JAK 1/3. Lepzacitinib exhibits anti-inflammatory effect and inhibits atopic dermatitis and other skin diseases.	price>
R-C-654	tariquidar cas:206873-63-4	Tariquidar(XR9576)is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line,reverses drug resistance in MDR cell Lines.	price>
R-R-2354	Dehydrocrenatidine CAS No.65236-62-6	Dehydrocrenatidine/CAS No.65236-62-6, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain.	price>
R-C-655	SKLB610 cas:1125780-41-7	SKLB610 is a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo.	price>
R-R-2355	Homoharringtonine CAS No.26833-87-4	Homoharringtonine (Omacetaxine mepesuccinate;HHT)/CAS No.26833-87-4 is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.	price>
R-C-656	Voxtalisib (XL765) CAS:934493-76-2	Voxtalisib(XL765)is a potent PI3K inhibitor,which has a similar activity toward class I PI3K (IC50s=39,113,9 and 43 nM for p110α,p110β,p110γ and p110δ, respectively),also inhibits DNA-PK(IC50=150 nM) and mTOR(IC50=157 nM).Voxtalisib (XL765)inhibits mTORC1 and mTORC2 with IC50s of 160 and 910 nM, respectively.	price>
R-R-2356	STAT6-IN-2 CAS No.1355594-85-2	STAT6-IN-2 (Comp R-84)/CAS No.1355594-85-2 is an inhibitor of STAT6. STAT6-IN-2 inhibits the secretion of chemokine eliciting eosinophil infiltration eotaxin-3. STAT6-IN-2 can be used for immune disease research.	price>
R-C-657	ENMD2076 cas:934353-76-1	ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM,25-fold selective for Aurora A than over Aurora B and less potent to RET,SRC,NTRK1/TRKA,CSF1R/FMS,VEGFR2/KDR,FGFR and PDGFRα.ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM,which induces apoptosis and G2/M phase arrest.	price>
R-R-2357	STAT6-IN-3 CAS No.371919-80-1	STAT6-IN-3 (Compound 18a)/CAS No.371919-80-1 is a STAT6 inhibitor (IC50= 44 nM). STAT6-IN-3 targets the Src Homology 2 (SH2) domain of STAT6. STAT6-IN-3 can be used for research of inflammation such as asthma.	price>
R-C-658	Amuvatinib (MP-470) CAS :850879-09-3	Amuvatinib(MP470)is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit,PDGFRα,Flt3,c-Met and c-Ret.Amuvatinib(MP470)is also a DNA repair suppressor through suppression of DNA repair protein RAD51,thereby disrupting DNA damage repair. Antineoplastic activity.	price>
R-R-2358	AS1517499 CAS No.919486-40-1	AS1517499/CAS No.919486-40-1 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.	price>
R-C-659	XL019 CAS:945755-56-6	XL019 is a potent,orally active,and selective JAK2 inhibitor,with IC50s of 2.2,134.3,and 214.2 nM for JAK2,JAK1 and JAK3,respectively.XL019 shows 50-fold or greater selectivity for JAK2,versus a panel of over 100 serine/threonine and tyrosine kinases,including other members of the JAK family.XL019 potently inhibits STAT3 and STAT5 phosphorylation in cells harboring either JAK2V617F or wild-type JAK2.	price>
R-R-2359	Cryptotanshinone CAS No.35825-57-1	Cryptotanshinone/CAS No.35825-57-1 is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.	price>
R-C-660	RKI1447 cas:1342278-01-6	RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.	price>
R-R-2360	STAT5-IN-1 CAS No.285986-31-4	STAT5-IN-1/CAS No.285986-31-4 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.	price>
R-C-661	SB1317 cas:937270-47-8	SB1317 is a potent inhibitor of CDK2,JAK2,and FLT3 for the treatment of cancer, with IC50 of 13,73,and 56 nM for CDK2,JAK2 and FLT3,respectively.	price>
R-R-2361	AC-4-130 CAS No.1834571-82-2	AC-4-130/CAS No.1834571-82-2 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML).	price>

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