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Catalog	name	Description	price
R-C-662	TAK632 cas: 1228591-30-7	TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50,2.4 nM;BRAF(wt),8.3 nM; CRAF,1.4 nM; pMEK (A375) IC50,12 nM;pMEK (HMVII), 49 nM;V/B ratio.	price>
R-R-2362	SD-36 CAS No.2429877-44-9	SD-36/CAS No.2429877-44-9 is a potent and efficacious STAT3 PROTAC degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase. SD-36 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-663	VALDECOXIB cas:181695-72-7	Valdecoxib is a sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID)with anti-inflammatory,analgesic,and antipyretic activities.Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2,thereby preventing the conversion of arachidonic acid into prostaglandins,which are involved in the regulation of pain,inflammation,and fever.This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation.	price>
R-R-2363	2-NP CAS No.65182-56-1	2-NP/CAS No.65182-56-1 is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells.	price>
R-C-664	Parecoxib 198470-84-7	Parecoxib(SC 69124)is a highly selective and orally active COX-2 inhibitor,the prodrug of Valdecoxib(HY-15762).Parecoxib Sodium is a nonsteroidal anti-inflammatory agent(NSAID)and inhibits prostaglandin(PG)synthesis.Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.	price>
R-R-2364	AS2863619 CAS No.2241300-51-4	AS2863619/CAS No.2241300-51-4 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene.	price>
R-C-665	GSK343 cas:1346704-33-3	GSK343 is a potent histone H3-lysine 27(H3K27)methyltransferase EZH2 inhibitor (IC= 4 nM).Diplays 1000-fold selectivity for other HMTs except EZH1(60-fold selectivity).GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).	price>
R-R-2365	Corylin CAS No.53947-92-5	Corylin/CAS No.53947-92-5 is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways.	price>
R-C-666	PF 4708671 CAS： 1255517-76-0	PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase(S6K1 isoform)with Ki/IC50 of 20 nM/160 nM in cell-free assays,400-fold greater selectivity for S6K1 than S6K2,and 4-and>20-fold selectivity for S6K1 than MSK1 and RSK1/2,respectively.PF-4708671 induces autophagy.First S6K1-specific inhibitor to be reported.	price>
R-R-2366	SI-109 CAS No.2429877-30-3	SI-109/CAS No.2429877-30-3 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36.	price>
R-C-667	Rilpivirine cas:500287-72-9	Rilpivirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI)with higher potency,longer half-life and reduced side-effect profile compared with older NNRTIs,such as efavirenz.	price>
R-R-2367	SC-43 CAS No.1400989-25-4	SC-43/CAS No.1400989-25-4, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects.	price>
R-C-668	XL413 (BMS-863233) cas: 1169562-71-3	BMS-863233,also known as XL-413,is an orally bioavailable cell division cycle 7 homolog(CDC7)kinase inhibitor with potential antineoplastic activity.	price>
R-R-2368	Colivelin CAS No.867021-83-8	Colivelin/CAS No.867021-83-8 is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease.	price>
R-C-669	BAY57-1293 cas:348086-71-5	Pritelivir(AIC316),an inhibitor of the viral helicase-primase complex,exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection.Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2)with the IC50 of 0.02 μM against HSV1-2.	price>
R-R-2369	Fraxinellone CAS No.28808-62-0	Fraxinellone/CAS No.28808-62-0 is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1.	price>
R-C-670	E7080(Lenvatinib) cas:417716-92-8	Lenvatinib(E7080)is an oral,multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3,FGFR1-4,PDGFR,KIT,and RET,shows potent antitumor activities.	price>
R-R-2370	AS1810722 CAS No.909561-15-5	AS1810722/CAS No.909561-15-5 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research.	price>
R-C-671	STA9090(Ganetespib) cas:888216-25-9	Ganetespib is a heat shock protein 90(HSP90)inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines.	price>
R-R-2371	Casticin CAS No.479-91-4	Casticin/CAS No.479-91-4 is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.	price>

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