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Catalog	name	Description	price
R-C-672	UNC1999 cas: 1431612-23-5	UNC1999 is a potent,orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays,respectively,showin>1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets.UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation,differentiation,and apoptosis.	price>
R-R-2372	HJC0152 CAS No.1420290-99-8	HJC0152/CAS No.1420290-99-8 is a signal transducers and activators of transcription 3 (STAT3) inhibitor.	price>
R-C-673	OSU-03012 cas:742112-33-0	OSU-03012 is a novel celecoxib derivative,without cyclooxygenase-2 inhibitory activity,capable of inducing apoptosis in various cancer cells types.	price>
R-R-2373	L002 CAS No.321695-57-2	L002/CAS No.321695-57-2 is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM. L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation. L002 has the potential for hypertension‐induced cardiac hypertrophy and fibrogenesis treatment.	price>
R-C-674	P529 cas:914913-88-5	Palomid 529 is a dual TORC1/2 inhibitor of the PI3K/Akt/mTOR pathway having broad activity in angiogenesis and cellular proliferation.	price>
R-R-2374	Stafia-1 CAS No.2582757-90-0	Stafia-1/CAS No.2582757-90-0 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.	price>
R-C-675	SB1518(Pacritinib) cas:937272-79-2	Pacritinib,also known as SB1518,is an orally bioavailable inhibitor of Janus kinase 2(JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity.Pacritinib competes with JAK2 for ATP binding,which may result in inhibition of JAK2 activation,inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.	price>
R-R-2375	Mogrol CAS No.88930-15-8	Mogrol/CAS No.88930-15-8 is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.	price>
R-C-676	AVL-292 cas:1202757-89-8	Spebrutinib(CC-292,AVL-292) is a covalent,orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM,displaying at least 1400-fold selectivity over the other kinases assayed.	price>
R-R-2376	YM-341619 CAS No.643082-52-4	YM-341619 (AS1617612)/CAS No.643082-52-4 is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation. YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma.	price>
R-C-677	Silica coated NaYF4:Yb,Er	Green Upconversion Luminescence(usually obtained at 980/525 and 544 nm excitation/emission wavelengths) is used for temperature measurement in turn. Then,the nanocomposites were applied to the dual-mode in vitro imaging of HepG-2 cells with temperature and O2.A novel multifunctional nano composite mesoporous silica coating NaYF4:Yb,Er@NaYF4 Upconversion ruthenium(II)complex nanoparticles have Green Upconversion Luminescence and red downconversion luminescence,which can be used for temperature detection,oxygen sensing and dual-mode cell imaging.	price>
R-R-2377	Picroside I CAS No.27409-30-9	Picroside I/CAS No.27409-30-9 is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ.	price>
R-C-678	Silica coated NaYF4:Yb,Tm	Carbon dots are embedded in the SiO2 coating on the surface of nano NaYF4:Yb,TM particles to form a relatively stable nanocomposite.The nanocomposites show interesting dual-mode luminescence properties,i.e.blue-green light under 365 nm ultraviolet lamp and blue violet light under 980 nm laser.	price>
R-R-2378	Stafib-1 CAS No.1688703-26-5	Stafib-1/CAS No.1688703-26-5 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM.	price>
R-C-679	Silica coated NaYF4:Yb,Er@NaYF4(980 excitation, green light)	Nano composite NaYF4:Yb,Er@NaYF4@mSiO2-Ru There are two working modes:its red down conversion luminescence (at 455/606nm excitation/emission peak)is quenched by oxygen(O2),which is used to sense and image O2.A novel multifunctional nano composite mesoporous silica coating NaYF4:Yb,Er@NaYF4 Upconversion ruthenium (II) complex nanoparticles have Green Upconversion Luminescence and red downconversion luminescence,which can be used for temperature detection,oxygen sensing and dual-mode cell imaging.	price>
R-R-2379	Ochromycinone CAS No.111540-00-2	Ochromycinone ((Rac)-STA-21)/CAS No.111540-00-2 is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity.	price>
R-C-680	Silica coated NaYF4:Yb,Tm@NaYF4(980 excitation, blue light)	Multi shell NaYF4:Yb,TM,Nd@NaYF4:Yb,Nd@SiO2@ZnO Active core/active shell upconversion nanoparticles(ucnps)were firstly combined with ZnO semiconductor to prepare nanospheres.	price>
R-R-2380	NSC-370284 CAS No.116409-29-1	NSC-370284/CAS No.116409-29-1 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5.	price>
R-C-681	Silica coated NaYF4,Yb,Er@NaYF4,Yb,Nd(808 excited, green)	Ucnps have attracted more and more attention as drug carriers,because it provides a unique opportunity to integrate treatment and diagnosis into a platform (therapeutics).Hexagonal NaYF4:Yb/erucnps were synthesized by microwave-assisted method,coated with porous silica and functionalized with amine.	price>
R-R-2381	STX-0119 CAS No.851095-32-4	STX-0119/CAS No.851095-32-4 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.	price>

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