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Catalog	name	Description	price
R-C-682	Silica coated NaYF4,Yb,Tm@NaYF4,Yb,Nd(808 excited, blue light)		price>
R-R-2382	Angoline CAS No.21080-31-9	Angoline/CAS No.21080-31-9 is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.	price>
R-C-683	NH2-silica NaYF4:Yb,Er (980 excitation, green light)	Dual-functional nanosensors based on small molecule regulation can be widely used due to their simplicity,high sensitivity and selectivity.glutathione (GSH) calibrated dual-functional system for GSH and cadmium ions(Cd2+)detection based on fluorescence resonance energy transfer(FRET)between NH2-NaYF4:Yb,Er/NaYF4@SiO2 upconversion nanoparticles(UCNPs)and gold nanoparticles (AuNPs)is designed.	price>
R-R-2383	NT219 CAS No.1198078-60-2	NT219/CAS No.1198078-60-2 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases.	price>
R-C-684	NH2-silica NaYF4:Yb,Tm (980 excitation, blue light)	NaYF4:20% Yb,0.5% TM upconversion luminescent nanoparticles(ucnps) were synthesized by solvothermal method,The morphology and luminescent properties of the water-soluble nanoparticles were characterized by scanning electron microscopy,X-ray diffraction analysis and luminescent spectroscopy.	price>
R-R-2384	STAT5-IN-2 CAS No.2111834-61-6	STAT5-IN-2/CAS No.2111834-61-6 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.	price>
R-C-685	NH2-silica NaYF4:Yb,Er@NaYF4(980 excitation, green light)	NH2-silica NaYF4:Yb,Er@NaYF4 The excitation wavelength of the product is 980nm, the emission wavelength is 540/650nm±15nm,the product emits green light, dissolves in water,and the particle size under the electron microscope is 50 ± 15nm.	price>
R-R-2385	UC-514321 CAS No.299420-83-0	UC-514321/CAS No.299420-83-0, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.	price>
R-C-686	NH2-silica NaYF4:Yb,Tm@NaYF4(980 excitation, blue light)	NH2-silica NaYF4:Yb,Tm@NaYF4 The surface ligand of(NH2) is NH2,the excitation wavelength is 980nm,the emission wavelength is 365/450/470nm±15nm,the light is blue,and the solvent is water.	price>
R-R-2386	AS2863619 free base CAS No.2241300-50-3	AS2863619 free base/CAS No.2241300-50-3 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.	price>
R-C-687	NH2-silica NaYF4,Yb,Er@NaYF4,Yb,Nd(808 excited, green)	NH2-silica NaYF4,Yb,Er@NaYF4 Yb, nd upconversion fluorescent nanomaterials with particle size of 50±15 and solvent of water under electron microscope.	price>
R-R-2387	LLL12 CAS No.1260247-42-4	LLL12/CAS No.1260247-42-4 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. LLL12 enhanced the inhibitory effect of Cisplatin (HY-17394) and Paclitaxel (HY-B0015) on ovarian cancer cell formation, migration, and growth.	price>
R-C-688	NH2-silica NaYF4,Yb,Tm@NaYF4,Yb,Nd (808 excitation, green light)	NH2-silica NaYF4,Yb,Tm@NaYF4 Yb, nd are amino silica products.They emit blue fluorescence at the emission wavelength of 808nm and the excitation wavelength of 365/450/470nm±15nm.The solvent is water.	price>
R-R-2388	inS3-54A18 CAS No.328998-53-4	inS3-54A18/CAS No.328998-53-4 is a potent STAT3 inhibitor, with anti-cancer properties.	price>
R-C-689	Mesoporous silica coating NaYF4:Yb,Er (980 excited, green)	Mesoporous silica coating NaYF4:Yb,ER are nanocomposites,which are composed of upconversion luminescent nanoparticles coated with mesoporous silica and oxygen sensitive luminescent ruthenium complexes.The emission wavelength is 980 nm and the surface ligand is Si oh.The emission of fluorescence is green.	price>
R-R-2389	Golotimod hydrochloride CAS No.1029401-59-9	Golotimod hydrochloride (SCV 07 hydrochloride)/CAS No.1029401-59-9, an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2).	price>
R-C-690	Mesoporous silica coating NaYF4:Yb,Tm (980 excited, blue light)	Mesoporous silica coating NaYF4:Yb,Er@NaYF4 upconversion nanoparticles loaded with ruthenium(II)complex nanoparticles:Fluorometric sensing and cellular imaging of temperature by upconversion and of oxygen by downconversion.	price>
R-R-2390	OSM-SMI-10B	OSM-SMI-10B a derivative of OSM-SMI-10. OSM-SMI-10B significantly reduces OSM-induced STAT3 phosphorylation in cancer cells upon co-incubation with OSM (Oncostatin M).	price>
R-C-691	Mesoporous silica coating NaYF4:Yb,Er@NaYF4(980 excitation, green light)	Nano composite NaYF4:Yb,@NaYF4@mSiO2-Ru There are two working modes:its red down conversion luminescence (at 455/606nm excitation/emission peak)is quenched by oxygen(O2),which is used to sense and image O2.Green Upconversion Luminescence(usually obtained at 980/525 and 544 nm excitation/emission wavelengths)is used for temperature measurement in turn.Then,the nanocomposites were applied to the dual-mode in vitro imaging of HepG-2 cells with temperature and O2.	price>
R-R-2391	PM-43I CAS No.1637532-77-4	PM-43I/CAS No.1637532-77-4 is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research.	price>

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