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Catalog	name	Description	price
R-C-722	Ampalex (CX-516) CAS:154235-83-3	CX516(BDP 12)is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer is disease,schizophrenia and mild cognitive impairment(MCI).	price>
R-R-2422	Nifuroxazide-d4 CAS No.1188487-83-3	Nifuroxazide-d4/CAS No.1188487-83-3 is the deuterium labeled Nifuroxazide. Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity.	price>
R-C-723	AR-A014418 CAS:487021-52-3	AR-A 014418 is a selective glycogen synthase kinase 3(GSK-3)inhibitor(IC50=104 nM).Exhibits specificity for GSK-3 over cdk2 and cdk5(IC50 values are>100 μM) and over 26 other kinases.Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.	price>
R-R-2423	Galiellalactone CAS No.133613-71-5	Galiellalactone/CAS No.133613-71-5 is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer.	price>
R-C-724	JNJ-26854165 (Serdemetan) CAS:881202-45-5	Serdemetan(JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells,inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.	price>
R-R-2424	HJC0416 hydrochloride CAS No.2415263-08-8	HJC0416 hydrochloride/CAS No.2415263-08-8 is a potent and orally active STAT3 inhibitor with an enhanced anticancer profile than Stattic (HY-13818). HJC0416 hydrochloride is a promising anti-cancer agent for breast cancer study.	price>
R-C-725	tcs1102 CAS No. : 916141-36-1	TCS 1102 is a potent,dual orexin receptor antagonist(Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).	price>
R-R-2425	Revumenib CAS No.2169919-21-3	Revumenib (SNDX-5613)/CAS No.2169919-21-3 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).	price>
R-C-726	Huperzine A CAS：102518-79-6	(-)-Huperzine A is a potent,highly specific and reversible inhibitor of acetylcholinesterase (AChE)with Ki of 7 nM,exhibiting 200-fold more selectivity for G4 AChE over G1 AChE.Also acts as an NMDA receptor antagonist.	price>
R-R-2426	Pelabresib CAS No.1380087-89-7	Pelabresib (CPI-0610)/CAS No.1380087-89-7 is a potent, selective, orally active and cell-active BET inhibitor. Pelabresib inhibits BRD4-BD1 with an IC50 of 39 nM, and with an EC50 value of 0.18 μM for MYC.	price>
R-C-727	AdipoRon (SC-396658) CAS No. 924416-43-3	AdipoRon(SC-396658)is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.	price>
R-R-2427	SRX3177 CAS No.2241237-51-2	SRX3177/CAS No.2241237-51-2 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC50s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), 3.3 nM (CDK6), respectively. SRX3177 exerts broad cytotoxic activity against cancer cells, but acts friendly with normal epithelial cells.	price>
R-C-728	CP673451 CAS No. 924416-43-3	CP-673451 is a selective inhibitor of PDGFRα/βwith IC50 of 10 nM/1 nM in cell-free assays,exhibits >450-fold selectivity over other angiogenic receptors,has antiangiogenic and antitumor activity.	price>
R-R-2428	SMD-3040	SMD-3040 is a potent and selective of SMARCA2 PROTAC degrader (DC50: 12 nM). SMD-3040 contains SMARCA2/4 ligand, linker and VHL ligand. SMD-3040 demonstrates excellent degradation selectivity for SMARCA2 protein over SMARCA4 protein.SMD-3040 achieves strong tumor growth inhibition in xenograft models.	price>
R-C-729	Capivasertib (AZD5363) CAS No. 1143532-39-1	AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo,has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.	price>
R-R-2429	Inobrodib CAS No.2222941-37-7	Inobrodib (CCS1477)/CAS No.2222941-37-7 is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression.	price>
R-C-730	UPF-1069 CAS NO. 1048371-03-4	UPF 1069 is a selective poly(ADP-ribose)polymerase (PARP)2 inhibitor(IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).	price>
R-R-2430	BRM/BRG1 ATP Inhibitor-1 CAS No.2270879-17-7	BRM/BRG1 ATP Inhibitor-1 (compound 14)/CAS No.2270879-17-7 is an orally active allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM. BRM/BRG1 ATP Inhibitor-1 has anticancer activity.	price>
R-C-731	VS-5584 (SB2343) CAS No. 1246560-33-7	VS-5584 is a pan-PI3K/mTOR kinase inhibitor with IC50s of 16 nM,68 nM,42 nM,25 nM,and 37 nM for PI3Kα,PI3Kβ,PI3Kδ,PI3Kγ and mTOR,respectively.VS-5584 simultaneously blocks mTORC2 as well as mTORC1.	price>
R-R-2431	dBET6 CAS No.1950634-92-0	dBET6/CAS No.1950634-92-0 is a highly potent, selective and cell-permeable PROTAC connected by ligands for Cereblon and BET, with an IC50 of 14 nM, and has antitumor activity.	price>

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