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Catalog	name	Description	price
R-C-732	Wnt-C59 (C59) CAS No. 1243243-89-1	Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.	price>
R-R-2432	MZ 1 CAS No.1797406-69-9	MZ 1/CAS No.1797406-69-9 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. MZ 1 potently and rapidly induces reversible, long-lasting, and selective removal of BRD4 over BRD2 and BRD3. Kds of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively.	price>
R-C-733	MK4827 CAS No. 1038915-60-4	Niraparib(MK-4827)is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM,respectively.Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.	price>
R-R-2433	ARV-825 CAS No.1818885-28-7	ARV-825/CAS No.1818885-28-7 is a PROTAC connected by ligands for Cereblon and BRD4. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively.	price>
R-C-734	SB216763 CAS No. 280744-09-4	SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM(similar potency for GSK3β).	price>
R-R-2434	666-15 CAS No.1433286-70-4	666-15/CAS No.1433286-70-4 is a potent and selective CREB inhibitor with an IC50 of 81 nM. 666-15 suppresses tumor growth in a breast cancer xenograft model.	price>
R-C-735	Plinabulin (NPI-2358) CAS NO. 714272-27-2	NPI-2358 is a synthetic analog of NPI-2350,a natural product isolated from Aspergillus sp.,which depolymerizes microtubules in A549 human lung carcinoma cells.	price>
R-R-2435	SGC-CBP30 CAS No.1613695-14-9	SGC-CBP30/CAS No.1613695-14-9 is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects.	price>
R-C-736	Atglistatin CAS No. 1469924-27-3	Atglistatin is a highly potent,selective and competitive inhibitor of adipose triglyceride lipase(ATGL)with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro,but no toxicity up to a concentration of 50 μM.	price>
R-R-2436	AU-15330 CAS No.2380274-50-8	AU-15330/CAS No.2380274-50-8 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity.	price>
R-C-737	FLI-06 CAS No. 313967-18-9	FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor.FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.	price>
R-R-2437	I-BET151 CAS No.1300031-49-5	I-BET151 (GSK1210151A)/CAS No.1300031-49-5 is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.	price>
R-C-738	erastin CAS No. 571203-78-6	Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.	price>
R-R-2438	ARV-771 CAS No.1949837-12-0	ARV-771/CAS No.1949837-12-0 is a powerful BET degrader based on PROTAC technology with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM and 7.6 nM for BRD2 (1) , BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1) and BRD4 (2), respectively.	price>
R-C-739	SCH-772984 CAS No. 942183-80-4	SCH772984 is a novel,specific inhibitor of ERK1/2 with IC50 values of 4 nM and 1 nM in cell-free assay,respectively,And show robust efficacy in RAS-or BRAF-mutant cancer cells.	price>
R-R-2439	dBET1 CAS No.1799711-21-9	dBET1/CAS No.1799711-21-9 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker.	price>
R-C-740	PF-3274167 cas:900510-03-4	Cligosiban (PF-3274167),a high oral bioavailability and good brain-penetrant non-peptide oxytocin receptor antagonist,shows a high-affinity(Ki=9.5 nM)and an excellent selectivity versus the vasopressin receptors with almost no affinity for the V1b and V1a subtypes.Cligosiban inhibits ejaculatory physiology in rodents.	price>
R-R-2440	dCBP-1 CAS No.2484739-25-3	dCBP-1/CAS No.2484739-25-3 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and ablates oncogenic enhancer activity driving MYC expression.	price>
R-C-741	ISRIB CAS : 1597403-47-8	ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM.	price>
R-R-2441	FHD-286 CAS No.2671128-05-3	FHD-286/CAS No.2671128-05-3 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia.	price>

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