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Catalog	name	Description	price
R-C-742	USP7-USP47 cas:1247825-37-1	USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor,with EC50s of 0.42 μM and 1.0 μM,respectively.	price>
R-R-2442	NSC 228155 CAS No.113104-25-9	NSC 228155/CAS No.113104-25-9 is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits the kinase-inducible domain (KID) of CREB and the KID-interacting domain (KIX) of CBP, with an IC50 of 0.36 μM.	price>
R-C-743	GSK1838705A CAS:1116235-97-2	GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L,respectively.	price>
R-R-2443	MG 149 CAS No.1243583-85-8	MG149 (Tip60 HAT inhibitor)/CAS No.1243583-85-8 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM).	price>
R-C-744	AZD628 CAS No. : 942436-93-3	AZD-6280 is a selective GABAA(α2/3) receptor modulator,used for treatment of generalized anxiety disorder.	price>
R-R-2444	Ziftomenib CAS No.2134675-36-6	Ziftomenib (KO-539)/CAS No.2134675-36-6 is an orally active menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151).	price>
R-C-745	NVP-QAV-572 CAS:957209-68-6	NVP-QAV-572 is a potent PI3K kianse inhibitor with IC50 of 10 nM.	price>
R-R-2445	GNE-781 CAS No.1936422-33-1	GNE-781/CAS No.1936422-33-1 is an orally active, highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model.	price>
R-C-746	LEE011 cas:1211441-98-3	Ribociclib(LEE01)is a highly specific CDK4/6inhibitor with IC50 values of 10 nM and 39 nM,respectively,and is over 1,000-fold less potent against the cyclin B/CDK1 complex.	price>
R-R-2446	GSK778 CAS No.2451862-42-1	GSK778 (iBET-BD1)/CAS No.2451862-42-1 is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 phenocopies the effects of pan-BET inhibitors in cancer models.	price>
R-C-747	APY29 cas:1216665-49-4	APY29,an ATP-competitive inhibitor,is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM.APY29 acts as a ligand that allosterically activates IRE1α adjacent RNase domain.	price>
R-R-2447	NEO2734 CAS No.2081072-29-7	NEO2734 (EP31670)/CAS No.2081072-29-7 is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC50 values of <30 nM for both p300/CBP and BET bromodomains. NEO2734 is active in SPOP mutant and wild-type prostate cancer.	price>
R-C-748	PTC-209 cas:315704-66-6	PTC-209 is a novel potent and selective BMI-1 inhibitor,targeting the BMI-1 self-renewal machinery with an IC50 of ~0.5 μM.	price>
R-R-2448	E-7386 CAS No.1799824-08-0	E-7386/CAS No.1799824-08-0 is an orally active CBP/beta-catenin modulator.	price>
R-C-749	TCS PIM-1 1 cas:491871-58-0	TCS PIM-1 1(SC 204330) is a potent,selective and ATP-competitive Pim-1 kianse inhibitor with an IC50 of 50 nM,displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM).	price>
R-R-2449	ZXH-3-26 CAS No.2243076-67-5	ZXH-3-26/CAS No.2243076-67-5 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM.	price>
R-C-750	NVP-BSK805 2HCl CAS No. 1942919-79-0	NVP-BSK805 is a potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor that potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.	price>
R-R-2450	BAY-850 CAS No.2099142-76-2	BAY-850/CAS No.2099142-76-2 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.	price>
R-C-751	BMS303141 cas: 943962-47-8	BMS303141 is a potent inhibitor of ATP citrate lyase(ACL).BMS303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM,and lowers plasma triglycerides in a murine hyperlipdemia model.	price>
R-R-2451	GSK046 CAS No.2474876-09-8	GSK046 (iBET-BD2)/CAS No.2474876-09-8 is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. GSK046 has immunomodulatory activity.	price>

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