Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-C-752	C7280948 cas:587850-67-7	C-7280948 is a selective and potent protein methyltransferase1(PRMT1)inhibitor with an IC50 value of 12.75 μM.	price>
R-R-2452	dTRIM24 CAS No.2170695-14-2	dTRIM24/CAS No.2170695-14-2 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.	price>
R-C-753	CVT-10216 cas:1005334-57-5	CVT-10216 is a highly selective,reversible aldehyde dehydrogenase-2(ALDH-2)inhibitor with an IC50 of 29 nM.CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM.CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects.	price>
R-R-2453	CPI-637 CAS No.1884712-47-3	CPI-637/CAS No.1884712-47-3 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 μM for CBP.	price>
R-C-754	GNF-5 cas:778277-15-9	GNF-5,an analogue of GNF-2 with improved pharmacokinetic properties,is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22±0.1 uM (Wild type Abl).	price>
R-R-2454	I-BRD9 CAS No.1714146-59-4	I-BRD9/CAS No.1714146-59-4 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways.	price>
R-C-755	PU-H71 cas:873436-91-0	PU-H71(NSC 750424)is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.	price>
R-R-2455	MI-3454 CAS No.2134169-43-8	MI-3454/CAS No.2134169-43-8 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis.	price>
R-C-756	EPZ5676 cas:1380288-87-8	Pinometostat(EPZ5676)is an S-adenosyl methionine(SAM)competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested,inhibits H3K79 methylation in tumor.	price>
R-R-2456	IACS-9571 hydrochloride CAS No.2319611-93-1	IACS-9571 (ASIS-P040) hydrochloride/CAS No.2319611-93-1 is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.	price>
R-C-757	KPT185 cas:133315-73-7	KPT185 is a selective CRM1 inhibitor.KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM,and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts.	price>
R-R-2457	VZ185 CAS No.2306193-61-1	VZ185/CAS No.2306193-61-1 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively.	price>
R-C-758	Romidepsin (FK228, Depsipeptide) cas:128517-07-7	Romidepsin(FK 228)is a Histone deacetylase(HDAC)inhibitor with anti-tumor activities.Romidepsin(FK 228)inhibits HDAC1,HDAC2,HDAC4,and HDAC6 with IC50s of 36 nM,47 nM,510 nM and 1.4 μM,respectively.Romidepsin(FK 228)is produced by Chromobacterium violaceum,induces cell G2/M phase arrest and apoptosis.	price>
R-R-2458	(R)-(-)-JQ1 Enantiomer CAS No.1268524-71-5	(R)-(-)-JQ1 Enantiomer/CAS No.1268524-71-5 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.	price>
R-C-759	LX1606 cas:1033805-22-9	LX 1606 is an orally bioavailable,small-molecule,tryptophan hydroxylase(TPH) inhibitor with potential antiserotonergic activity.	price>
R-R-2459	GNE-049 CAS No.1936421-41-8	GNE-049/CAS No.1936421-41-8 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively.	price>
R-C-760	sgc0946 CAS No. 1561178-17-3	SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM;selectively kill mixed lineage leukaemia cells.	price>
R-R-2460	FHT-1015 CAS No.2368903-18-6	FHT-1205/CAS No.2368903-18-6 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC50s of ≤10 nM (WO2020160180A1; compound 67).	price>
R-C-761	SKLB1002 cas:1225451-84-2	SKLB1002 is a new potent VEGFR2 inhibitor,which could significantly inhibit HUVEC proliferation,migration,invasion,and tube formation.	price>
R-R-2461	GSK2801 CAS No.1619994-68-1	GSK2801/CAS No.1619994-68-1 is a potent, selective, orally active and cell active acetyl-lysine competitive BAZ2A and BAZ2B bromodomains inhibitor with Kd values of 136 nM and 257 nM, respectively. GSK2801 shows >50-fold selectivity for BAZ2A/B over BRD4.	price>

455456457458459460 461462463464465