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Catalog	name	Description	price
R-R-2475	SGC-iMLLT CAS No.2255338-25-9	SGC-iMLLT/CAS No.2255338-25-9 is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC50 of 0.26 μM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with Kds of 0.129 and 0.077 μM, respectively.	price>
R-C-776	Colloidal gold modified azide	Colloidal gold modified azide compounds can be used for click chemistry based chemical reactions.	price>
R-R-2476	GNE-272 CAS No.1936428-93-1	GNE-272/CAS No.1936428-93-1 is a potent and selective CBP/EP300 inhibitor with IC50 values of 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively. GNE-272 is also an in vivo selective probe for CBP/EP300.	price>
R-C-777	Modification of alkynyl group with colloidal gold	Colloidal gold is a kind of stable colloidal state,called colloidal gold,which is polymerized by the chlorogold(HAuCl4)under the action of reducing agents such as white phosphorus,ascorbic acid,sodium citrate and tannin.	price>
R-R-2477	GNE-987 CAS No.2417371-71-0	GNE-987/CAS No.2417371-71-0 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50=0.03 nM for EOL-1 AML cell line). GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50=4.7 and 4.4 nM, respectively). GNE-987 incorporates a potent BET binder/inhibitor, a VHL-binding fragment, and a ten methylene spacer moiety. GNE-987 can be used in PROTAC-Antibody Conjugate (PAC).	price>
R-R-2478	MS645 CAS No.2250091-96-2	MS645/CAS No.2250091-96-2 is a bivalent BET bromodomains (BrD) inhibitor with a Ki of 18.4 nM for BRD4-BD1/BD2. MS645 spatially constrains bivalent inhibition of BRD4 BrDs resulting in a sustained repression of BRD4 transcriptional activity in solid-tumor cells.	price>
R-C-779	NOTA-NHS ester	Macrocyclic ligands and their use as MRI contrast agents,including bifunctional chelating agents,macrocyclic ligands,magnetic resonance reagents,reaction intermediates and a series of products.NHS(N-hydroxysuccinimide)esters and other active esters(sulfo NHS, sulfotetrafluorophenyl STP)are suitable for amino modification.NHS is the most common active ester.The common modifications are fluorescent labeling,fluorescence quenching agent and other reporter groups.	price>
R-R-2479	dBET57 CAS No.1883863-52-2	dBET57/CAS No.1883863-52-2 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. dBET57 mediates recruitment to the CRL4Cereblon E3 ubiquitin ligase, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2.	price>
R-R-2480	ZL0580 CAS No.2377151-10-3	ZL0580/CAS No.2377151-10-3, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.	price>
R-R-2481	PROTAC BRD4 ligand-1 CAS No.2313230-51-0	PROTAC BRD4 ligand-1/CAS No.2313230-51-0 is a potent BET inhibitor and a ligand for target BRD4 protein for PROTACT GNE-987 (HY-129937A).	price>
R-C-782	MAL-PEG113-PLys	Maleimide is an organic compound,chemical formula is c4h3no2,flake crystal,easy to sublimate,soluble in water,ether and ethanol.Polyethylene glycol(PEG)is a kind of high molecular polymer,which has no irritation,slightly bitter taste,good water solubility and good compatibility with many organic components.The two ends of PEG are linked with mal and polylysine.	price>
R-R-2482	CBP/p300-IN-12 CAS No.2738688-57-6	CBP/p300-IN-12/CAS No.2738688-57-6 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450.	price>
R-C-783	TCO-PEG5000-Maleimide	As a kind of amphiphenyl,trans cyclooctene(TCO)has the advantages of no catalyst and fast reaction rate in physiological conditions.It has been widely used in the research of biology and materials science.Peg can enhance solubility and stability,reduce the surface non-specific binding of charged molecules,and reduce the immunogenicity of polypeptide.	price>
R-R-2483	PF-CBP1 hydrochloride CAS No.2070014-93-4	PF-CBP1 hydrochloride/CAS No.2070014-93-4 is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1β, IL-6 and IFN-β) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders.	price>
R-R-2484	BAY1238097 CAS No.1564268-08-1	BAY1238097/CAS No.1564268-08-1 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome (IC50 <100 nM).	price>
R-C-785	PBA-PEG1000-cRGD	1-Pyrenebutyric acid(PBA)is a conjugated polymer that has a large π system and a carboxylic group.It is majorly used in surface functionalization.It has a high fluorescence efficiency and stability that make it useful in optoelectronic applications.	price>
R-R-2485	(S)-JQ-35 CAS No.1349719-98-7	(S)-JQ-35 (TEN-010)/CAS No.1349719-98-7 is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity.	price>
R-C-786	Compound customization (Rhodamine fluorescence)	Rhodamine is a laser dye,which is used for biological dyeing.It is a fluorescent dye,catechol.Rhodamine B is mainly used for industrial dyeing,and it is fat soluble.Rhodamine B has strong fluorescence in solution,so it can be used as fluorescent staining agent in laboratory.	price>
R-R-2486	ACBI2 CAS No.2913161-19-8	ACBI2/CAS No.2913161-19-8 is a highly potent and orally active VHL PROTAC SMARCA2 degrader (EC50: 7 nM), which selectively degrades SMARCA2 with a DC50 value of 1 nM in RKO cells. ACBI2 can be used in the research of lung cancer.	price>
R-C-787	18：1DGS_NTA	1,2-dioleoyl-sn-glycero-3-[(n-(5-amino-1-carboxyphenyl)iminodiacetic acid) succenyl](nickel salt)is a customized product from Ruixi biotechCo.Ltd.	price>

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