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Catalog	name	Description	price
R-C-829	NHS-PEG2000-RGD	Polyethylene glycol(PEG)is a kind of high molecular polymer,which has no irritation,slightly bitter taste,good water solubility and good compatibility with many organic components.RGD sequence is composed of arginine,glycine and aspartic acid,and exists in a variety of extracellular matrix.It can specifically bind with 11 integrins,which can effectively promote cell adhesion to biomaterials.	price>
R-R-2529	CBP/p300-IN-8 CAS No.2304416-91-7	CBP/p300-IN-8/CAS No.2304416-91-7 is a potent inhibitor of the CBP/P300 family of bromodomains. CBP/p300-IN-8 inhibits CBP (IC50=0.01-0.1 µΜ) and BRD4 (IC50=1-1000 µΜ) activity.	price>
R-C-830	PLGA5K-hyd-PEG5K	Poly(lactic co glycolic acid)-Hyde poly(ethylene glycol)is a kind of amphiphilic block copolymer,which is linked by the acid sensitive chemical bond of hydrazone bond.The micelle products made by this product can break and release drugs in the fixed pH environment.	price>
R-R-2530	NI-42 CAS No.1884640-99-6	NI-42 (compound 13-d)/CAS No.1884640-99-6, a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins.	price>
R-C-831	Encapsulation of Fe3O4 by Cy5 labeled peg cationic liposomes	Cy5 labeled PEGylated cationic liposomes containing Fe3O4 are provided by Ruixi biological Co.,Ltd.we can also provide CY labeled peptide antibody protein and polysaccharide products.	price>
R-R-2531	M-1211 CAS No.2377337-93-2	M‑1121/CAS No.2377337-93-2 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.	price>
R-C-832	PLGA5K-PEG2K-TAT（YGRKKRRQRRRC）	Targeted transmembrane peptide(TAT)(ygrkrrqrrr-nh2)is a classic cell transmembrane peptide,which has strong cell penetrating power and can directly act on the nucleus.Poly (lactic co glycolic acid)is a kind of degradable functional polymer,which is randomly polymerized by two monomers lactic acid and glycolic acid.It has good biocompatibility,non-toxic,good properties of encapsulation and film formation.It is widely used in pharmaceutical,medical engineering materials and modern industrial fields.	price>
R-R-2532	UNC926 CAS No.1184136-10-4	UNC926/CAS No.1184136-10-4 is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM.	price>
R-R-2533	TMX1	TMX1 is a BRD4 covalent molecular glue degrader. TMX1 selectively recruits DCAF16 to BRD4BD2, resulting in the degradation of BRD4.	price>
R-C-834	PLGA5000-PEI1800-PEG2000	In order to reduce the influence of acidic microenvironment on protein drugs in PLGA microspheres and improve the stability and bioavailability of protein drugs during storage and administration,it is necessary to use a cationic polymer with low cytotoxicity and good biocompatibility as a buffer material for microenvironment acidification of PLGA microspheres.Pei-peg,a water-soluble cross-linking compound formed by the cross-linking of low molecular weight pei1800 and PEG2000,has been reported to have the advantage of low cytotoxicity.	price>
R-R-2534	Naphthol AS-E CAS No.92-78-4	Naphthol AS-E/CAS No.92-78-4 is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 µM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 µM. Naphthol AS-E can be used for cancer research.	price>
R-C-835	PEG10K-PGA6K	The PEG10K-PGA6K provided by Ruixibio is a customized synthetic reagent.PEG was grafted onto polyglutamic acid with molecular weights of 1K,2K,5K,10K and 20K, and polyglutamate with molecular weights of 1500,7500,15K,30K,45k and 60K,and the corresponding repeat units of glutamic acid were10,50,100,200,300 and 400, respectively.	price>
R-R-2535	MI-2-2 CAS No.1454920-20-7	MI-2-2/CAS No.1454920-20-7 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.	price>
R-C-836	NH2-PEG2K-Dopamine	NH2-PEG2K-Dopamine can be used to modify proteins,peptides and other materials and small molecules with carboxyl(-COOH)or other active groups that can react with primary amines.Amino(-NH2)can easily form stable amide bond with carboxyl group,and can also form amide bond with active ester(-NHS) in ph7-8.5. Polyethylene glycol can increase solubility and stability.It can also inhibit the non-specific binding of charged molecules on the modified surface.	price>
R-R-2536	TPOP146 CAS No.2018300-62-2	TPOP146/CAS No.2018300-62-2 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4.	price>
R-C-837	PEG-PAE（200nm）	PAEs poly(β-amino esters) is a kind of hydrophobic polymer,which is often combined with PEG as a amphiphilic copolymer.Peg-b-pae is used to prepare pH responsive micelles.When PAE is in acidic environment,it becomes soluble by protonation of amino groups in the structure.Based on the characteristic of charge transition under acidic condition of PAE,the acidic environment of tumor is used as a signal to trigger PAE to release the encapsulated drug.The main feature of MPEG PAEs is that we can start from the synthetic monomer of PAEs and change its structure,so that the amphiphilic copolymer of MPEG PAEs can destroy its structure and release drugs at different pH values.The pH response range is 5-8,that is,the micelle of MPEG PAEs can respond to ph5-5.3,ph5-5.5,ph6.5-6.8 and weak base 5-8 response.We can also modify various active groups or target molecules,such as folic acid,at the end of PEG.	price>
R-R-2537	M-89 CAS No.2363165-42-6	M-89/CAS No.2363165-42-6 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia.	price>
R-C-838	DSPE-TK-mPEG2K	DSPE-TK-mPEG,DSPE-TK-mPEG2K is a widely used phospholipid polyethylene glycol,which is an attractive amphiphilic lipid polymer conjugate,including hydrophilic peg and extremely hydrophobic fatty acids.In addition,DSPE-PEG is not only widely used as a key self-assembly material for anticancer drug delivery,but also as an additive for surface functionalized drug delivery systems.We can provide peg molecular weights of 1k, 2k, 3.4k, 5k, and 10k for this product.	price>
R-R-2538	Amredobresib CAS No.1610044-98-8	Amredobresib/CAS No.1610044-98-8 is a potent inhibitor of BET. Amredobresib inhibits the binding of bromodomains to acetylated lysines on histone H3 and H4 and thus acts as important regulators of gene transcription. Amredobresib is useful for the research of acute myeloid leukemia (AML) and cancer (extracted from patent WO2019145410A1 and WO2021175824A1).	price>
R-C-839	PCL2K-PEOz2K-COOH	PCL-PEOz,Poly(ε-caprolactone)-Poly(2-ethyl-2-oxazoline)is an amphiphilic AB blockcopolymer,PEOz can As apolymer long chain polymer,PEOz has good water solubility,flexibility andbiocompatibility,PEOzcan completely substitute PEG polyethylene glycol as drug carrier material,PCL-PEOz can be used to prepare PHresponsive micelle for drug delivery。	price>

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