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Catalog	name	Description	price
R-R-2539	FL-411 CAS No.2118944-88-8	FL-411/CAS No.2118944-88-8 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.	price>
R-C-840	Drug entrapment in mesoporous silica(requimod) 50NM	Mesoporous silica nanoparticles (MSNs) have the advantages of uniform particle size distribution,good water dispersion,ultra-high specific surface area,narrow pore size distribution and large pore volume,and good biocompatibility.It can be used as an excellent carrier for fluorescent molecules,chemotherapy drugs,DNA / siRNA,protein and other guest molecules for biomedical applications such as diagnosis.	price>
R-R-2540	PROTAC BET Degrader-1 CAS No.2093386-22-0	PROTAC BET Degrader-1/CAS No.2093386-22-0 is a PROTAC connected by ligands for Cereblon and BET, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.	price>
R-C-841	Mesoporous silica encapsulated fluorescence (FITC) 50nm	Monodisperse mesoporous silica nanoparticles(MSNs)have the advantages of uniform size distribution,good water dispersibility,ultra-high specific surface area, narrow pore size distribution and large pore volume,and good biocompatibility.It can be used as an excellent carrier for fluorescent molecules,chemotherapy drugs, DNA/siRNA,protein and other guest molecules for biomedical applications such as diagnosis and treatment.	price>
R-R-2541	SNIPER(BRD)-1 CAS No.2095244-54-3	SNIPER(BRD)-1/CAS No.2095244-54-3, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively.	price>
R-C-842	PEG44-PCL60-TSPBA	Ruixibio can provide polyphylene glycol poly(ε-caprolactone)-tspbaPEG-PCL can be used in targeted drug research and widely used in protein carrier and ligand crosslinking.Polyethylene glycol polycaprolactone can be made into drug loaded microspheres,microcapsules,vesicles and micelles,which can be used to achieve sustained release and controlled release of drugs.It can also be used as a tissue engineering scaffold material with good hydrophilicity.	price>
R-R-2542	CeMMEC1 CAS No.440662-09-9	CeMMEC1/CAS No.440662-09-9 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC50 of 0.9 μM for TAF1, and a Kd of 1.8 μM for TAF1 .	price>
R-C-843	Ge11-PEG2000-PCL2000	Peptide ge11 is a small molecule peptide obtained by phage peptide library screening technology,which is composed of 11 amino acids (yhwygytpqnvi). Compared with natural macromolecular ligands,peptide ligands have the advantages of small molecular weight,low immunogenicity,easy diffusion and high targeting, which can meet the requirements of targeting tumor,and have no effect on the growth of tumor cells.Studies have shown that ge11 can specifically bind to EGFR,and ge11 has no effect on cell growth.The results showed that the liposomes modified with ge11 had high targeting to EGFR.	price>
R-R-2543	Molibresib besylate CAS No.1895049-20-3	Molibresib besylate (GSK 525762C; I-BET 762 besylate)/CAS No.1895049-20-3 is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.	price>
R-C-844	DOPE-RB	DOPE-Rhodamine B(RB)，Rhodamine,also known as rhodamine or rose red,is a series of related fluorone heterocyclic compounds,which can be used as dyes.Among them,rhodamine 6G, Rhodamine B,rhodamine 123,rhodamine WT and so on are common.It can be used as gain medium for dye and dye laser.	price>
R-R-2544	PROTAC BET Degrader-10 CAS No.1957234-97-7	PROTAC BET Degrader-10/CAS No.1957234-97-7 is a potent BET protein BRD4 degrader extracted from patent WO2017007612A1, example 37, connected by ligands for Cereblon and BRD4, with a DC50 of 49 nM.	price>
R-C-845	PEI1.8K-19-fluorodecanoic acid	Perfluorodecanoic acid is an environmental pollutant,belonging to the perfluorochemical(PFCs)class of compounds.These compounds are widely used as surfactants,polymer and plastic additives,wetting agents,corrosion inhibitors, lubricants,foam-fire extinguishants,etc.	price>
R-R-2545	MZP-55 CAS No.2010159-48-3	MZP-55/CAS No.2010159-48-3 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 8 nM for Brd4BD2.	price>
R-C-846	Sulfo-Cy7 azide	A water-soluble NIR dye azide for Click Chemistry.Sulfo-Cyanine7 is a cyanine dye,an analog of Cy7® with improved photophysical properties.This dye is a perfect choice for NIR imaging studies in live organisms.	price>
R-R-2546	GSK761	GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC50 value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS)-induced inflammatory activation. GSK761 induces the production of CD206+ regulatory macrophages by inhibiting SP140.	price>
R-C-847	Cyanine3-vancomycin	Vancomycin is a glycopeptide antibiotic,which is used to treat many bacterial infections.It can inhibit the synthesis of bacterial cell wall,has strong effect on Staphylococcus aureus,Streptococcus pyogenes and Streptococcus pneumoniae, and also has good effect on Bacillus difficile,Bacillus anthracis and diphtheria.	price>
R-R-2547	ODM-207 CAS No.1801503-93-4	ODM-207 (BET-IN-4)/CAS No.1801503-93-4 is a potent BET bromodomain protein (BRD4) inhibitor, with an IC50 of ≤ 1 μM.	price>
R-C-848	Alginate-Thiol	Alginate is mainly sodium alginate from brown algae(such as Laminaria)or soil bacteria(such as brown nitrogen fixing bacteria)Sodium alginate,a biodegradable hydrophilic polysaccharide,can be used as microspheres for drug delivery system. Alginate-Thiol is a derivative of sodium alginate that introduces thiol groups(-SH) into its molecular structure through chemical modification.It has unique adhesion and reactivity.	price>
R-R-2548	Tz-Thalidomide CAS No.2087490-42-2	Tz-Thalidomide/CAS No.2087490-42-2 is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.	price>
R-C-849	BSA-AuNCs	At the excitation wavelength of 670nm and 520nm,aubsca-525 shows good emission. When FITC is used as a reference fluorophore,FITC/BSA auncs show good linear response in the temperature range of 1-71℃,and provide temperature independent spectral shift,temperature accuracy,activation energy and reusability.The high temperature induced fluorescence quenching of FITC/BSA auncs may be due to the weakening of Au-S bond,which reduces the charge transfer from BSA to auncs.	price>

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