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Catalog	name	Description	price
R-R-2620	Luspatercept CAS No.1373715-00-4	Luspatercept (ACE-536)/CAS No.1373715-00-4 is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia.	price>
R-C-921	Carboxylated Ti3C2 mxene quantum dots(30-60nm)	Mxene materials have attracted more and more attention in electrochemical energy storage applications,and mxene also has photoactivity on the scale of quantum dots,making it a substitute for solar energy conversion equipment.A Janus structure cobalt nanoparticles coupled Ti3C2 mxene quantum dots(CO mqd)Schottky catalyst with adjustable cobalt loading was demonstrated,which can be used as photoanode for Photoelectrochemical water oxidation.The introduction of cobalt can induce the surface plasmon effect and act as the oxidation center of water, so as to realize the visible light collection ability and improve the surface reaction kinetics.	price>
R-R-2621	Carotuximab CAS No.1268714-50-6	Carotuximab (TRC105)/CAS No.1268714-50-6 is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions.	price>
R-C-922	Carboxylated Ti3C2 mxene quantum dots(Within 10nm)	Mxene materials have attracted more and more attention in electrochemical energy storage applications,and mxene also has photoactivity on the scale of quantum dots,making it a substitute for solar energy conversion equipment.A Janus structure cobalt nanoparticles coupled Ti3C2 mxene quantum dots (CO mqd) Schottky catalyst with adjustable cobalt loading was demonstrated,which can be used as photoanode for Photoelectrochemical water oxidation.The introduction of cobalt can induce the surface plasmon effect and act as the oxidation center of water,so as to realize the visible light collection ability and improve the surface reaction kinetics.	price>
R-R-2622	SIS3 free base CAS No.521985-36-4	SIS3 free base/CAS No.521985-36-4 is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2.	price>
R-C-923	Doxorubicin modified by carboxylated Ti3C2 mxene(Within 10nm)	Mxene materials have attracted more and more attention in electrochemical energy storage applications,and mxene also has photoactivity on the scale of quantum dots,making it a substitute for solar energy conversion equipment.A Janus structure cobalt nanoparticles coupled Ti3C2 mxene quantum dots(CO mqd) Schottky catalyst with adjustable cobalt loading was demonstrated,which can be used as photoanode for Photoelectrochemical water oxidation.The introduction of cobalt can induce the surface plasmon effect and act as the oxidation center of water, so as to realize the visible light collection ability and improve the surface reaction kinetics.Doxorubicin is an anti-tumor antibiotic,which can inhibit the synthesis of RNA and DNA.It has the strongest inhibitory effect on RNA and a wide range of anti-tumor spectrum.Doxorubicin has effects on a variety of tumors.It is a cycle nonspecific drug and has killing effect on tumor cells in various growth cycles.	price>
R-R-2623	Livmoniplimab CAS No.2412004-88-5	Livmoniplimab (ABBV-151; ARGX-115)/CAS No.2412004-88-5 is a potent, humanized monoclonal antibody against the LRRC32 (GARP)/TGFβ1 complex. Livmoniplimab blocks LRRC32-mediated latent TGFβ1 activation and release. Livmoniplimab has potential in cancer research as a single anticancer agent or in combination with an anti-PD-1 mAb to inhibit locally advanced or metastatic solid tumors (NCT03821935).	price>
R-C-924	Biotin rosin acid	Rosin acid is a kind of tricyclic diterpenoid oxygenated compound,which is one of the most important resin acids.Insoluble in water,soluble in general organic solvents and dilute sodium hydroxide solution,soluble in alcohol,benzene, chloroform,acetone,ether and carbon disulfide.Biotin is also known as vitamin H and coenzyme R.its main function is to act as coenzyme in decarboxylation carboxylation reaction and deamination reaction.It can transfer CO2 from one compound to another,so that one compound becomes another.	price>
R-R-2624	SJ000063181 CAS No.945189-68-4	SJ000063181/CAS No.945189-68-4 is a potent BMP signaling activator with an EC50 ≤1 µM. SJ000063181 can be used as chemical probes to interrogate BMP signaling due to it can penetrate zebrafish embryos.	price>
R-C-925	DOPE-PEG12-(KIAALKK)4-CONH2	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol) has both hydrophilicity and hydrophobility and is the excellent liposome formation material that can be used for drug delivery,gene transfection and vaccine delivery as well.Moreover,these material can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.	price>
R-R-2625	Trabedersen CAS No.925681-61-4	Trabedersen (AP 12009)/CAS No.925681-61-4 is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon.	price>
R-C-926	PEGylation of picosetron on mesoporous silicon	PEG modified mesoporous silica nanoparticles(MSNs PEG)were used as drug delivery carriers for Danshensu.Through the method of CO hydrolysis and condensation with silane coupling agent,PEG grafting changed the drug release law and could effectively prolong the release time of Danshensu.With the increase of PEG grafting amount(mass fraction),the release rate of Danshensu could be effectively controlled.Click chemistry method can effectively control the grafting amount of PEG(mass fraction)and the release rate of Danshensu.	price>
R-R-2626	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine CAS No.2347517-69-3	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine/CAS No.2347517-69-3 is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia.	price>
R-C-927	poly(β-amino esters) Encapsulated DNA	The main synthesis method of PBAE is Michael addition reaction.The results showed that PBAE with different end groups had different gene transfection efficiency,and the hydrophilic amino group containing hydroxyl or extra amine had the best transfection efficiency;the amino group in the polymer was protonated under acidic conditions,and could bind to the drug or DNA containing negative ions,so that it could be effectively encapsulated.Because there were only tertiary amines in the straight chain PBAE,and there might be primary and secondary amines in the branched chain PBAE,When DNA nanoparticles were formed, the encapsulation ability of branched chain PBAE was stronger than that of straight chain PBAE,and the diameter of branched chain amino ester nanoparticles was smaller.	price>
R-R-2627	Trimethylamine N-oxide-d9 CAS No.1161070-49-0	Trimethylamine N-oxide-d9/CAS No.1161070-49-0 is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.	price>
R-C-928	Biotin-THZ1	THZ1 is a selective CDK7 inhibitor that preferentially diminishes transcription in cancer cells.THZ1 has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain,providing an unanticipated means of achieving selectivity for CDK7.	price>
R-R-2628	Isoviolanthin CAS No.40788-84-9	Isoviolanthin/CAS No.40788-84-9, a flavonoid glycoside, could markedly inhibit TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the TGF-β/Smad and PI3K/Akt/mTOR pathways in HCC cells. Isoviolanthin exhibits no cytotoxic effects on normal liver LO2 cells.	price>
R-C-929	FA-hyaluronic acid-PAE（PAE20% FA7%）	Hyaluronic acid is a biochemical drug with high clinical value,which is widely used in cosmetics.It can play a unique role in protecting the skin.It can keep the skin moist,smooth,delicate,tender and elastic.It has the functions of anti wrinkle,anti wrinkle,beauty care and recovery of skin physiological function.	price>
R-R-2629	ALK5-IN-34 CAS No.2785430-90-0	ALK5-IN-34/CAS No.2785430-90-0 is an selective orally active activin receptor-like kinase (ALK) inhibitor. ALK5-IN-34 can inhibit the activity of ALK5-IN-34 with an IC50 value of ≤10 nM. ALK5-IN-34 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer.	price>
R-C-930	TTVP	TTVP (Tris (4-vinylphenyl) vinylphosphine) is a water-soluble red fluorescent material, while AIE represents Aggregation Induced Emission. Therefore, TTVP water-soluble red AIE aggregation induced luminescence material refers to a material that utilizes the molecular characteristics of TTVP to induce aggregation induced luminescence in a water-soluble environment.	price>

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