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Catalog	name	Description	price
R-C-971	0prozomib(ONX0912) cas:935888-69-0	Oprozomib(onx 0912;pr047)is an oral biocompatible inhibitor, which can inhibit the ct-l activity of 20S proteasome (20S proteasome)β 5/LMP7 with IC50 of 36 nm /82 nm.	price>
R-R-2671	Basimglurant CAS No.802906-73-6	Basimglurant (RG7090)/CAS No.802906-73-6 is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM. Basimglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-972	MS-275 cas:209783-80-2	MS-275 is an inhibitor of HDAC (histone deacetylase) that preferentially inhibits HDAC1(IC50=300 nM)over HDAC3(IC50=8 μM).However,MS-275 does not inhibit HDAC8 (IC50>100μM).MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1),slowing cell growth,differentiation,and tumor development in vivo.Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs,like adriamycin,inhibitors of poly(ADP-ribose)polymerase(PARP),or inhibitors of heat shock protein 90 (Hsp90).	price>
R-R-2672	MSOP CAS No.66515-29-5	MSOP/CAS No.66515-29-5 is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.	price>
R-R-2673	MPEP CAS No.96206-92-7	MPEP/CAS No.96206-92-7 is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects. MPEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-974	Obatoclax mesylate cas:803712-79-0	Obatoclax Mesylate is the mesylate salt of obatoclax,a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities.Obatoclax binds to members of the Bcl-2 protein family,preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells.The Bcl-2 family of proteins(bcl-2,bcl-xl, bcl-w,and Mcl-1)are overexpressed in a wide variety of cancers,including those of the lymphatic system,breast,lung,prostate,and colon.	price>
R-R-2674	VU0650786 CAS No.1809085-30-0	VU0650786/CAS No.1809085-30-0 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.	price>
R-C-975	Vatalanib CAS 212141-54-3	Vatalanib,also called as PTK 787 or CGP 797870,is a small molecule that interacts reversibly and competitively at the ATP-binding site of the receptor tyrosine kinase domain to inhibit autophosphorylation.It targets all known VEGFR tyrosine kinases.	price>
R-R-2675	mGluR2 antagonist 1 CAS No.1432728-49-8	mGluR2 antagonist 1/CAS No.1432728-49-8 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability.	price>
R-C-976	Quizartinib (AC220) cas:950769-58-1	Quizartinib(AC220)is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor,with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM,respectively.Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader.Quizartinib induces apoptosis.	price>
R-R-2676	L-Glutamine-15N CAS No.80143-57-3	L-Glutamine-15N/CAS No.80143-57-3 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-977	N6022 cas:1208315-24-5	N6022 is a new and first-class drug with strong inhibitory activity on S-nitrosoglutathione reductase (gsnor).Gsnor is an enzyme that plays an important role in the metabolism of S-nitrosoglutathione(GSNO)and the maintenance of nitric oxide(no)homeostasis.N6022 is a highly binding,specific and reversible gsnor inhibitor with IC50 of 8 nm and Ki of 2.5 nm.	price>
R-R-2677	CDPPB CAS No.781652-57-1	CDPPB/CAS No.781652-57-1 is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5. CDPPB may provide an approach for development of antipsychotic agents.	price>
R-C-978	PP1 (Src Inhibitor) cas:172889-26-8	PP 1 is a selective and potent Src family tyrosine kinase inhibitor.PP 1 studies have proved its ability to potently inhibit Lck and Fyn(FynT),IL-2 gene activation in T lymphocytes,and anti-CD3-induced protein tyrosine phosphorylation.Research indicates that PP 1 effectively blocks LPA and EGF-enhanced tyrosine phosphorylation,MAPK activation downstream of EGFR,Rsk-1 (p90RSK)activation by H2O2,Kit and Bcr-Abl tyrosine kinases,and degrades RETMEN2A and RETMEN2B oncoproteins via proteosomal targeting.Rat basophilic leukemia cell studies have shown that PP1 inhibits Fc εRI- and Thy-1-mediated activation.Structural studies have revealed that PP1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases.	price>
R-R-2678	JNJ-40411813 CAS No.1127498-03-6	JNJ-40411813 (ADX-71149)/CAS No.1127498-03-6 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. JNJ-40411813 has orally bioactivity and penetrate the blood-brain barriers. JNJ-40411813 has the potential property of anti-depression.	price>
R-C-979	Trelagliptin(syr472) cas:865759-25-7	Trelagliptin(SYR-472)succinate is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM.Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).	price>
R-R-2679	AMN082 CAS No.97075-46-2	AMN082/CAS No.97075-46-2, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.	price>
R-C-980	TUS-68(SU6668,Orantinib)	Orantinib(TSU-68,SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay,but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation,little activity against IGF-1R,Met,Src,Lck,Zap70,Abl and CDK2;does not inhibit EGFR.	price>
R-R-2680	L-Glutamine-1-13C CAS No.159663-16-8	L-Glutamine-1-13C/CAS No.159663-16-8 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-981	A769662 cas:844499-71-4	A-769662 is a potent,reversible AMPK activator with EC50 of 0.8 μM in cell-free assays,little effect on GPPase/FBPase activity.	price>

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