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Catalog	name	Description	price
R-R-2681	VU6005649 CAS No.2137047-43-7	VU6005649/CAS No.2137047-43-7 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.	price>
R-C-982	TAK960 CAS:1137868-52-0	TAK-960 is an orally available,selective inhibitor of polo-like kinase 1 (PLK1),with an IC50 of 0.8 nM.TAK-960 also shows inhibitory activities against PLK2 and PLK3,with IC50s of 16.9 and 50.2 nM,respectively.TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.	price>
R-R-2682	L-Glutamine-d5 CAS No.14341-78-7	L-Glutamine-d5/CAS No.14341-78-7 is the deuterium labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-983	PS48 cas:1180676-32-7	PS 48 has been shown to be a PKB Kinase(phosphoinositide-dependent protein kinase-1,PDK1)activator(Kd=10.3 μM).Studies have indicated that this compound selectively binds to the PIF-binding pocket of PKB Kinase(PDK1).This is a distinct region separate from the ATP binding site.	price>
R-R-2683	L-Glutamine-15N2 CAS No.204451-48-9	L-Glutamine-15N2/CAS No.204451-48-9 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-984	Bosutinib(SKI-606) CAS:380843-75-4	Bosutinib(SKI-606)is a novel,dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays,respectively.Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR,MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK,p-S6,and p-STAT3.Bosutinib promotes autophagy.	price>
R-R-2684	VU6012962 CAS No.2313526-86-0	VU6012962/CAS No.2313526-86-0 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM) with an IC50 of 347 nM.	price>
R-C-985	Asunaprevir(BMS-650032) cas:630420-16-5	Asunaprevir(BMS-650032)is an orally bioavailable inhibitor of the hepatitis C virus enzyme serine protease NS3 that is necessary for protein processing required for viral replication.	price>
R-R-2685	AZD-8529 CAS No.1092453-15-0	AZD-8529/CAS No.1092453-15-0 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.	price>
R-C-986	(Obeticholic Acid)INT-747 CAS No. 459789-99-2	Obeticholic acid(INT-747)is a potent, selective and orally active FXR agonist with an EC50 of 99 nM.Obeticholic acid has anticholeretic and anti-inflammation effect.Obeticholic acid also induces autophagy.	price>
R-R-2686	LY3020371 hydrochloride CAS No.1377615-44-5	LY3020371 hydrochloride/CAS No.1377615-44-5 is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM. LY3020371 hydrochloride exerts an antidepressant-like signature in vivo.	price>
R-C-987	FH535 cas:108409-83-2	FH535 is an inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ.1 At 15 µM,FH535 blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ.1 Presumably through these actions,FH535 is selectively toxic to some carcinoma cell lines expressing the Wnt/β-catenin pathway.1 FH535 is used to study the role of Wnt/β-catenin pathway in various cancer cell lines.	price>
R-R-2687	(S)-3,5-DHPG CAS No.162870-29-3	(S)-3,5-DHPG/CAS No.162870-29-3 is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia.	price>
R-C-988	ML323 cas:1572414-83-5	ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay.The measured inhibition constants of ML-323 for the free enzyme(Ki)is 68 nM.	price>
R-R-2688	L-Cysteinesulfinic acid CAS No.1115-65-7	L-Cysteinesulfinic acid/CAS No.1115-65-7 is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.	price>
R-C-989	EMD-1214063 cas:1100598-32-0	EMD-1214063 is an inhibitor of met tyrosine kinase with IC50 of 4 nm.The selectivity of emd-1214063 to c-met is 200 times higher than that to irak4, TrkA,Axl,irak1 and mer.It has potential antitumor activity.It binds to met tyrosine kinase and destroys met signal transduction pathway,which may induce apoptosis in tumor cells overexpressing met tyrosine kinase.	price>
R-R-2689	DL-AP3 CAS No.5652-28-8	DL-AP3/CAS No.5652-28-8 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect.	price>
R-C-990	Tivozanib (AV-951) cas:475108-18-0	Tivozanib(AV-951,KRN-951)is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM,and also inhibits PDGFR and c-Kit,low activity observed against FGFR-1,Flt3,c-Met,EGFR and IGF-1R.	price>
R-R-2690	CPPG CAS No.183364-82-1	CPPG ((RS)-CPPG)/CAS No.183364-82-1 is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors.	price>
R-C-991	FG4592 CAS No. 808118-40-3	The hypoxia-inducible factor(HIF)pathway alters gene expression in response to low oxygen tension.Under normoxic conditions,HIF-specific prolyl hydroxylases (HIF-PHs)initiate the degradation of oxygen-sensitive HIF isoforms.As 2-oxoglutarate(2-OG)is a required co-factor for HIF-PH activity,analogs of 2-OG may inhibit HIF-PH and prevent HIF turnover.1 FG-4592 is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs.While little has been published regarding the actions of this compound,similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression,promoting erythropoiesis or preventing anemia in vivo.	price>

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