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Catalog	name	Description	price
R-R-2691	Quisqualic acid CAS No.52809-07-1	Quisqualic acid (L-Quisqualic acid)/CAS No.52809-07-1, a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica.	price>
R-C-992	ww298	WW298 is the first effective inhibitor of the Mdmx–p53 interaction.	price>
R-R-2692	BMS-984923 CAS No.1375752-78-5	BMS-984923/CAS No.1375752-78-5, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling.	price>
R-C-993	WK23	WK23 is an inhibitor based on four aromatic groups and able to efficiently fill the binding pockets of MDM2/MDMX,its median inhibitory concentration(IC50) values to MDM2/MDMX are 1.17 and 36 uM,respectively.	price>
R-R-2693	CALP1 TFA	CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity.	price>
R-C-994	YH249	YH249 is the first highly specific,direct p300/β-catenin antagonist.	price>
R-R-2694	Fenobam CAS No.57653-26-6	Fenobam/CAS No.57653-26-6 is a selective, orally active, and brain-penetrant mGluR5 antagonist acting at an allosteric modulatory site (Kds of 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity.	price>
R-C-995	CID755673 cas:521937-07-5	CID755673 is a potent PKD inhibitor with IC50s of 182 nM,280 nM and 227 nM for PKD1,PKD2 and PKD3,respectively.	price>
R-R-2695	UPF-523 CAS No.168560-79-0	UPF-523 (AIDA)/CAS No.168560-79-0, a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis.	price>
R-C-996	GSK2636771 cas:1372540-25-4	GSK2636771 is a potent,orally bioavailable and selective inhibitor of PI3Kβ with >900-fold selectivity over PI3Kα/PI3Kγ and >10-fold over PI3Kδ.Sensitive to PTEN null cell lines.	price>
R-R-2696	Decoglurant CAS No.911115-16-7	Decoglurant (RO4995819)/CAS No.911115-16-7 is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant.	price>
R-C-997	WHI-P154 cas:211555-04-3	WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50=1.8 μM versus IC50s>10 μM for JAK1 and JAK2).1It has been reported to inhibit additional kinases including EGFR (IC50= 4 nM)and VEGFR as well as the non-receptor tyrosine kinases,Abl,Lck,and Src.1WHI-P154 is cytotoxic to human glioblastoma cells(IC50=813 nM) and has been used to induce the differentiation of neuronal precursor cells.	price>
R-R-2697	Ro 01-6128 CAS No.302841-86-7	Ro 01-6128/CAS No.302841-86-7 is a positive allosteric modulator of mGluR1.	price>
R-C-998	AS-252424 cas:900515-16-4	AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform.It inhibits human recombinant PI3Kγ,α,β,and δ with IC50 values of 30,940, 20,000,and 20,000 nM respectively.	price>
R-R-2698	VU0422288 CAS No.1630936-95-6	VU0422288 (ML396)/CAS No.1630936-95-6 is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice.	price>
R-C-999	INCB28060 cas:1029712-80-8	INCB28060,a novel inhibitor of c-MET kinase.INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases.This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.	price>
R-R-2699	CVN636 CAS No.2226732-62-1	CVN636/CAS No.2226732-62-1 is a potent, orally active and selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability.	price>
R-C-1000	CNX1351 cas:1276105-89-5	CNX-1351 is a covalent inhibitor of PI3Kα(IC50=6.8 nM).1 It is selective for PI3Kα over PI3Kβ,-γ,and-δ(IC50s=166,240.3,and 3,020 nM,respectively),as well as PI3KC2A,PI3KC,PI4Kα,PI4Kβ,SPHK1,and SPHK2 (IC50s=>1 µM for all).CNX-1351 (500 nM)inhibits phosphorylation of Akt in SKOV3 cells.It inhibits the growth of SKOV3 and MCF-7 cancer cells(GI50s=77.6 and 54.7 nM,respectively).CNX-1351(100 mg/kg)inhibits Akt phosphorylation in mouse spleen.	price>
R-R-2700	trans-ACPD CAS No.67684-64-4	trans-ACPD/CAS No.67684-64-4, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.	price>
R-C-1001	TAE684 (NVP-TAE684) cas:761439-42-3	TAE684(NVP-TAE684)is a selective inhibitor of ALK with IC50 value of 3 nM .TAE684(NVP-TAE684)is a potent ALK inhibitor and has a different selectivity with the reported ALK inhibitor crizotinib.When tested with ALCL cell lines—Karpas-299 and SU-DHL-1 expressing NPM-ALK,TAE684(NVP-TAE684)inhibited cell proliferation and cell apoptosis in dose-dependent manner.In lung cancer cell lines harboring wild-type,H694R or E1384K mutant ALKs,TAE684 showed effective inhibition on cell proliferation and phospho-Y1604 ALK expression of H694R or E1384K mutant ALK,but also to a degree higher than that of wild-type ALK.	price>

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