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Catalog	name	Description	price
R-C-1057	EHT 1864 2HCl CAS: 754240-09-0	EHT 1864 is an inhibitor of Rac family small GTPases.EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation.The Kd values are 40,50,60,and 230 nM for Rac1,Rac1b,Rac2 and Rac3,respectively.EHT 1864 also potently inhibits other Rac-dependent transformation processes,Tiam1- and Ras-mediated growth transformation.EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo.	price>
R-R-2757	rel-ACPT-I CAS No.194918-76-8	rel-ACPT-I/CAS No.194918-76-8 is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects.	price>
R-C-1058	INH1 CAS:313553-47-8	INH1 specifically disrupts the Hec1/Nek2 interaction via direct Hec1 binding. INH1 shows promising cancer inhibition activity both in vitro and in vivo.	price>
R-R-2758	A-841720 CAS No.869802-58-4	A-841720/CAS No.869802-58-4 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research.	price>
R-C-1059	INH6 CAS：1001753-24-7	INH6 is a potent Hec1 inhibitor,which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.	price>
R-R-2759	XAP044 CAS No.196928-50-4	XAP044/CAS No.196928-50-4 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms.	price>
R-C-1060	E7010(ABT-751) CAS：141430-65-1	ABT-751(E7010)binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules,not a substrate for the MDR transporter and is active against cell lines resistant to vincristine,doxorubicin,and cisplatin.	price>
R-R-2760	(±)-LY367385 CAS No.198419-90-8	(±)-LY367385/CAS No.198419-90-8 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a.	price>
R-C-1061	AC55541 CAS：916170-19-9	AC-55541 is a highly selective protease-activated receptor 2(PAR2)agonist (pEC50=6.7),displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation.	price>
R-R-2761	Ro 67-4853 CAS No.302841-89-0	Ro 67-4853/CAS No.302841-89-0 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation.	price>
R-C-1062	ZK-811752(BX-471) CAS:217645-70-0	BX471(ZK-811752)is an orally active, potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM,and exhibits 250-fold selectivity for CCR1 over CCR2,CCR5 and CXCR4.	price>
R-R-2762	TC-N 22A CAS No.1314140-00-5	TC-N 22A/CAS No.1314140-00-5 is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo.	price>
R-C-1063	PFI-3 CAS:1819363-80-8	PFI-3 is a selective chemical probe for SMARCA bromodomains,including SMARCA2, SMARCA4 and PB1(5)bromodomains.	price>
R-R-2763	O-Phospho-L-serine-13C3,15N CAS No.2734706-69-3	O-Phospho-L-serine-13C3,15N/CAS No.2734706-69-3 is the 13C- and 15N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.	price>
R-C-1064	LY2835219 CAS：1231929-97-7	LY2835219 mesylate is a potent and selective CDK4/6 dual inhibitor with potential antineoplastic activity.CDK4/6 dual inhibitor LY2835219 has been shown in vitro to be a selective ATP-competitive inhibitor of CDK4/6 that inhibits phosphorylation of the Rb tumor suppressor protein and thereby induces G1 cell cycle arrest.Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition,thereby arresting the cell cycle in the G1 phase,suppressing DNA synthesis and inhibiting cancer cell growth.LY2835219 is being investigated in a phase I clinical trial and in a clinical trial for the treatment of mantle cell lymphoma.	price>
R-R-2764	(S)-4CPG CAS No.134052-73-6	(S)-4CPG ((S)-4-Carboxyphenylglycine)/CAS No.134052-73-6 is a potent mGluR2 agonist. (S)-4CPG reduces hyperalgesia and allodynia associated with sciatic nerve contraction injury in rats. (S)-4CPG can be used in research on neurological diseases.	price>
R-C-1065	D-64131(sc-203908) CAS:74588-78-6	D-64131 is an orally active tubulin inhibitor,with an IC50 of 0.53 μM for tubulin polymerization.D-64131 has antimitotic activity.D-64131 can be used for cancer research.	price>
R-R-2765	CBiPES CAS No.353235-01-5	CBiPES/CAS No.353235-01-5 is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM. CBiPES attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity. CBiPES can be used for research of neurological diseases.	price>
R-C-1066	JW55 CAS：664993-53-7	JW 55 efficacy causes stabilization of Axin2.JW 55 also decreases canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines.Inhibitor of the PARP domain of tankyrase 1 and 2(TNKS1/2).JW 55 inhibits the β-catenin signaling pathway.It Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines;JW 55 reduces cell cycle progression and proliferation in SW480 cells in vitro.	price>
R-R-2766	SIB-1757 CAS No.31993-01-8	SIB-1757/CAS No.31993-01-8 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM.	price>

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