Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-2731	LY2979165 CAS No.1311385-32-6	LY2979165/CAS No.1311385-32-6 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist.	price>
R-C-1032	epothilone A CAS No. 152044-53-6	Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition,leading to cytotoxicity.	price>
R-R-2732	CPPHA CAS No.693288-97-0	CPPHA/CAS No.693288-97-0 is potent and selective positive allosteric modulator (PAM) of the mGluR5 and mGluR1 (metabotropic glutamate receptor). CPPHA can potentiate responses of mGluR5 and mGluR1 to activation of these receptors. CPPHA is developed for the research of central nervous system disorders.	price>
R-C-1033	Moxidectin CAS No. 113507-06-5	Moxidectin(ProHeart 6;CL301423;Cydectin)is an anthelmintic drug which kills parasitic worms(helminths),and is used for the prevention and control of heartworm and intestinal worms.	price>
R-R-2733	BMT-145027 CAS No.2018282-44-3	BMT-145027/CAS No.2018282-44-3 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM.	price>
R-C-1034	Ulixertinib (BVD-523) CAS No. 869886-67-9	Ulixertinib is an orally available inhibitor of extracellular signal-regulated kinase(ERK)1 and 2,with potential antineoplastic activity.Upon oral administration,ulixertinib inhibits both ERK 1 and 2,thereby preventing the activation of ERK-mediated signal transduction pathways.This results in the inhibition of ERK-dependent tumor cell proliferation and survival.The mitogen-activated protein kinase(MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.	price>
R-R-2734	Valiglurax CAS No.1976050-09-5	Valiglurax (VU0652957)/CAS No.1976050-09-5 is a potent, orally active and selective mGlu4 positive allosteric modulator with EC50 values of 64.6 nM and 197 nM for hmGlu4/Gqi5 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant.	price>
R-C-1035	ALK inhibitor 2 CAS NO. 761438-38-4	ALK inhibitor 2(compound 18)is a potent pyrimidin ALK inhibitor.ALK inhibitor 2 is a potent inhibitor of testis-specific serine/threonine kinase 2(TSSK2;IC50=37 nM)and focal adhesion kinase(FAK;IC50=5 nM).	price>
R-R-2735	VU0360172 CAS No.1310012-12-4	VU0360172/CAS No.1310012-12-4 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice. VU0360172 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1036	MK8745 CAS No. 885325-71-3	MK-8745 is a novel Aurora-A specific inhibitor.It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.	price>
R-R-2736	L-AP4 monohydrate CAS No.2247534-79-6	L-AP4 (L-APB) monohydrate/CAS No.2247534-79-6 is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.	price>
R-R-2737	LY2389575 hydrochloride CAS No.885104-09-6	LY2389575 hydrochloride/CAS No.885104-09-6 is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels.	price>
R-C-1038	Vandetanib (ZD6474) CAS No. 443913-73-3	Vandetanib(ZD6474)is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay.It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM,respectively.Not sensitive to PDGFRβ,Flt1,Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM.No activity against MEK,CDK2,c-Kit,erbB2,FAK,PDK1,Akt and IGF-1R with IC50 above 10 μM. Vandetanib(ZD6474)increases apoptosis and induces autophagy by increasing the level of reactive oxygen species(ROS).	price>
R-R-2738	VU0080241 CAS No.393845-24-4	VU0080241/CAS No.393845-24-4 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 4 (mGluR4), with an EC50 of 4.6 μM.	price>
R-C-1039	GSK126 CAS No. 1346574-57-9	GSK126 is a potent,highlyselective,S-adenosyl-methionine-competitive,small-molecule inhibitor of EZH2 methyltransferase activity,decreases global H3K27me3 levels and reactivates silenced PRC2 target genes.	price>
R-R-2739	VU-1545 CAS No.890764-63-3	VU-1545/CAS No.890764-63-3 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM.	price>
R-C-1040	MX1013 CAS NO. 582316-00-5	MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1,caspase-3, and caspase-6,7,8,and 9.	price>
R-R-2740	MNI137 CAS No.946619-21-2	MNI137/CAS No.946619-21-2 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization.	price>
R-C-1041	Mitomycin C CAS:50-07-7	Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis,used to treat different cancers.Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.	price>
R-R-2741	ML254 CAS No.1428630-86-7	ML254/CAS No.1428630-86-7 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>

482483484485486487 488489490491492