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Catalog	name	Description	price
R-C-1008	PFI-1 (PF-6405761) cas:1403764-72-6	PFI-1(PF-6405761)is a highly selective BET(bromodomain-containing protein)inhibitor for BRD4 with IC50 of 0.22 μM and for BRD2 with IC50 of 98 nM in a cell-free assay.	price>
R-R-2708	Biphenylindanone A CAS No.866823-73-6	Biphenylindanone A (BINA)/CAS No.866823-73-6 is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders.	price>
R-C-1009	GNZ-644282 cas:529488-28-6	Genz-644282 is a non-camptothecin topoisomerase I(Topo I)inhibitor that demonstrates potent cytotoxic activity with a median IC50 of 1.2 nM(range 0.2 nM-21.9 nM).Genz-644282 can be used in cancer research.	price>
R-R-2709	ABP688 CAS No.924298-51-1	ABP688/CAS No.924298-51-1 is a high affinity human mGluR5 antagonist with anKi of 1.7 nM. Radioisotope-labeled ABP688 can be used as a PET tracer for clinical imaging of the mGlu5 receptor.	price>
R-C-1010	CH5138303 cas:959763-06-5	CH5138303 is a triazine Hsp90 inhibitor.1 CH5138303 binds to the N-terminus of Hsp90α(Kd=0.52 nM)and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro(IC50s=89 and 66 nM,respectively).CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts(ED50=3.9 mg/kg)and displays high oral bioavailability in mice.	price>
R-R-2710	FITM CAS No.932737-65-0	FITM/CAS No.932737-65-0 is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM.	price>
R-C-1011	B-RAF cas:1093100-40-3	BRAF is a human gene that encodes a protein called B-Raf.The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B,while the protein is more formally known as serine/threonine-protein kinase B-Raf.	price>
R-R-2711	LY456236 CAS No.338736-46-2	LY456236/CAS No.338736-46-2 is a selective, non-competitive and orally active mGlu1 receptor antagonist that inhibits phosphoinositide hydrolysis with an IC50 of 0.145 μM. LY456236 also inhibits EGFR with an IC50 of 0.91 μM.	price>
R-C-1012	Losmapimod(GW-856553) cas:585543-15-3	Losmapimod,also know as GW856553 or GW856553X,is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.	price>
R-R-2712	Methoxy-PEPy CAS No.524924-76-3	Methoxy-PEPy/CAS No.524924-76-3 is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.	price>
R-C-1013	AMG-706 CAS No. 857876-30-3	Motesanib Diphosphate(AMG 706 Diphosphate)is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM,respectively,and has similar activity against Kit,and is approximately 10-fold more selective for VEGFR than PDGFR and Ret.	price>
R-R-2713	Pomaglumetad methionil hydrochloride CAS No.635318-26-2	Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride)/CAS No.635318-26-2 is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research.	price>
R-C-1014	TMP-269 cas:1314890-29-3	TMP 269 is a potent,selective class IIa HDAC inhibitor with IC50 of 157 nM,97 nM,43 nM and 23 nM for HDAC4,HDAC5,HDAC7 and HDAC9,respectively.	price>
R-R-2714	HTL14242 CAS No.1644645-32-8	HTL14242 (HTL0014242)/CAS No.1644645-32-8 is an advanced and orally active mGlu5 NAM with a pKi and a pIC50 of 9.3 and 9.2, respectively.	price>
R-C-1015	CPI203 CAS No. 1446144-04-2	CPI203 is an analog of the BET inhibitor(BETi)(+)-JQ1 and is bioavailable via oral or intraperitoneal administration.It plays an important role in lenalidomide and dexamethasone functions in in vitro and in vivo models of multiple myeloma.CPI203 inhibits proliferation,apoptosis and cell cycle arrest in A431 cell line and primary skin squamous cell carcinoma(SCC)cells.CPI203 is an inhibitor of BRD4,a bromodomain-containing protein that binds to histones to regulate recruitment of transcription factors.BRD4 is also an RNA Pol II kinase. CPI203 blocks BRD4 kinase activity in cells and in vivo.It has shown synergistic antitumor activity with lenalidomide in bortezomib-resistant mantle cell lymphoma.	price>
R-R-2715	(1R,2S)-VU0155041 CAS No.1263273-14-8	(1R,2S)-VU0155041/CAS No.1263273-14-8, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM.	price>
R-C-1016	TH-237A CAS NO. 935467-97-3	TH-237A is a novel neuroprotective agent,which possess protective properties against β-amyloid(Aβ)-induced neurodegeneration associated with Alzheimer is disease.	price>
R-R-2716	AZD-8529 mesylate CAS No.1314217-69-0	AZD-8529 mesylate/CAS No.1314217-69-0 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.	price>
R-C-1017	JQ-1 CAS NO. 202592-23-2	JQ-1 carboxylic acid is a(+)-JQ1 derivative(a BET bromodomain inhibitor).JQ-1 carboxylic acid can be used as a precursor to synthesize PROTACs,which targets BET bromodomains.	price>
R-R-2717	ML353	ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an Ki value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a agent blocker. ML353 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>

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