Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-2762	TC-N 22A CAS No.1314140-00-5	TC-N 22A/CAS No.1314140-00-5 is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo.	price>
R-C-1063	PFI-3 CAS:1819363-80-8	PFI-3 is a selective chemical probe for SMARCA bromodomains,including SMARCA2, SMARCA4 and PB1(5)bromodomains.	price>
R-R-2763	O-Phospho-L-serine-13C3,15N CAS No.2734706-69-3	O-Phospho-L-serine-13C3,15N/CAS No.2734706-69-3 is the 13C- and 15N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.	price>
R-C-1064	LY2835219 CAS：1231929-97-7	LY2835219 mesylate is a potent and selective CDK4/6 dual inhibitor with potential antineoplastic activity.CDK4/6 dual inhibitor LY2835219 has been shown in vitro to be a selective ATP-competitive inhibitor of CDK4/6 that inhibits phosphorylation of the Rb tumor suppressor protein and thereby induces G1 cell cycle arrest.Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition,thereby arresting the cell cycle in the G1 phase,suppressing DNA synthesis and inhibiting cancer cell growth.LY2835219 is being investigated in a phase I clinical trial and in a clinical trial for the treatment of mantle cell lymphoma.	price>
R-R-2764	(S)-4CPG CAS No.134052-73-6	(S)-4CPG ((S)-4-Carboxyphenylglycine)/CAS No.134052-73-6 is a potent mGluR2 agonist. (S)-4CPG reduces hyperalgesia and allodynia associated with sciatic nerve contraction injury in rats. (S)-4CPG can be used in research on neurological diseases.	price>
R-C-1065	D-64131(sc-203908) CAS:74588-78-6	D-64131 is an orally active tubulin inhibitor,with an IC50 of 0.53 μM for tubulin polymerization.D-64131 has antimitotic activity.D-64131 can be used for cancer research.	price>
R-R-2765	CBiPES CAS No.353235-01-5	CBiPES/CAS No.353235-01-5 is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM. CBiPES attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity. CBiPES can be used for research of neurological diseases.	price>
R-C-1066	JW55 CAS：664993-53-7	JW 55 efficacy causes stabilization of Axin2.JW 55 also decreases canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines.Inhibitor of the PARP domain of tankyrase 1 and 2(TNKS1/2).JW 55 inhibits the β-catenin signaling pathway.It Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines;JW 55 reduces cell cycle progression and proliferation in SW480 cells in vitro.	price>
R-R-2766	SIB-1757 CAS No.31993-01-8	SIB-1757/CAS No.31993-01-8 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM.	price>
R-C-1067	7-ACC2 CAS:1472624-85-3	7ACC2 is a potent monocarboxylate transporter(MCT)inhibitor with an IC50 of 11 nM for inhibition of[14C]-lactate influx.7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport.7ACC2 is an anticancer agent through inhibition of lactate flux.	price>
R-R-2767	L-Glutamine-13C5,15N2,d5 CAS No.2123439-02-9	L-Glutamine-13C5,15N2,d5/CAS No.2123439-02-9 is the deuterium, 13C-, and 15-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-1068	Gandotinib (LY2784544) CAS:1229236-86-5	LY2784544 is a small molecule selective mutant JAK2 kinase inhibitor with an IC50 of 68 nM.The antiproliferative activity of LY2784544 and its ability to induce apoptosis were examined by Celltiter-Glo Cell Viability and Caspase-Glo 3/7 Apoptosis Assays,respectively.In the in vitro tests using Ba/F3 cells expressing either wild type or V617F mutant JAK2,it potently inhibited the JAK2 V617F-STAT5 signaling at a concentration that was 41-fold lower than that required to inhibit IL-3-activated wild type JAK2-STAT5 signaling(IC50=0.055 uM for JAK2 V617F vs.2.26 uM for WT JAK2).Similarly in the proliferation assay, LY2784544 selectively inhibited the JAK2 V617F-driven cell proliferation(IC50= 0.068 uM).Inhibition of JAK2 V617F signaling correlated well with the induction of apoptosis(EC50=0.113 uM)in Ba/F3 cell model.	price>
R-R-2768	CBiPES hydrochloride CAS No.856702-40-4	CBiPES hydrochloride/CAS No.856702-40-4 is a mGlu2 receptor positive allosteric modulator (EC50: 92.8 nM). CBiPES hydrochloride attenuates stress-induced hyperthermia and PCP-induced hyperlocomotor activity. CBiPES hydrochloride can be used for research of neurological disease.	price>
R-C-1069	REVERSINE CAS：656820-32-5	Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 12 nM/13 nM/20 nM,respectively.Also used for stem cell dedifferentiation.	price>
R-R-2769	(S,S)-BMS-984923 CAS No.1375752-77-4	(S,S)-BMS-984923/CAS No.1375752-77-4 is a less active (S,S)-enantiomer of BMS-984923. (S,S)-BMS-984923 shows an EC50 >1μM for mGluR5 receptor. BMS-984923 is a potent mGluR5 silent allosteric modulator. (S,S)-BMS-984923 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1070	SU9516 CAS：377090-84-1	SU9516 is a potent,selective cdk2 inhibitor.It inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest.	price>
R-R-2770	ML289 CAS No.1382481-79-9	ML289 (VU0463597)/CAS No.1382481-79-9 is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5. ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1071	yk-4-279 CAS:1037184-44-3	YK-4-279 is a ETV1 inhibitor,which inhibitor protein-protein interactions between ES-FLI1 and RHA.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.YK-4-279,prevents prostate cancer growth and metastasis in a mouse xenograft model.	price>
R-R-2771	VU0469650 CAS No.1443748-47-7	VU0469650/CAS No.1443748-47-7 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM.	price>
R-C-1072	CX-6258HCL CAS:1353859-00-3	CX-6258 HCl is a potent,orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM,25 nM and 16 nM for Pim1,Pim2,and Pim3.	price>

485486487488489490 491492493494495