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Catalog	name	Description	price
R-R-2772	ZJ43 CAS No.723331-20-2	ZJ43/CAS No.723331-20-2 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models.	price>
R-C-1073	(R)-FL-118 CAS:151636-76-9	(R)-FL-118 is a derivative of Camptothecin(C175150),which is antitumor alkaloid that binds to the DNA-topoisomerase I complex,inhibiting the reassociation of DNA after cleavage by topoisomerase I,trapping the enzyme in a covalent linkage with DNA.	price>
R-R-2773	FEMA 4774 CAS No.1359963-68-0	FEMA 4774/CAS No.1359963-68-0 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer.	price>
R-C-1074	TBA-354 CAS:1257426-19-9	TBA-354 is a potent anti-tuberculosis compound;maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates.	price>
R-R-2774	Pramlintide acetate CAS No.187887-46-3	Pramlintide acetate/CAS No.187887-46-3 is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer.	price>
R-C-1075	BMH-21 CAS：896705-16-1	BMH-21 is a potent small molecule DNA intercalator.BMH-21 binds ribosomal DNA and inhibits RNA polymerase I(Pol I)transcription.	price>
R-R-2775	a-CGRP (mouse, rat) (TFA)	α-CGRP (mouse, rat) TFA, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) TFA can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) TFA has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.	price>
R-C-1076	Poziotinib (HM781-36B) CAS：1092364-38-9	Poziotinib(HM781-36B)is an orally active,irreversible pan-HER inhibitor,which effectively inhibits EGFRwt,HER-2 and HER-4 with IC50s of 3.2, 5.3 and 23.5 nM, respectively.Poziotinib(HM781-36B)also shows excellent inhibitory activities against mutated EGFRs,including EGFRT790M and EGFRL858R/T790M,with IC50s of 4.2 and 2.2 nM,respectively.Excellent antitumor activity.	price>
R-R-2776	Cagrilintide acetate	Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies.	price>
R-C-1077	PF-431396 CAS：717906-29-1	PF-431396 hydrate has been used as a dual inhibitor of proline-rich tyrosine kinase 2(PYK2)/focal adhesion kinase(FAK)inhibitor to study its effects on phosphorylation of Yes-associated protein(YAP)at Ser127 and steady state of transcriptional coactivator with PDZ-binding motif(TAZ).It has also been used as a PYK2/FAK inhibitor to study its effects on protein kinase A activation in human sperm samples.	price>
R-R-2777	b-CGRP, human TFA	β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.	price>
R-C-1078	GSK2578125A CAS:1285515-21-0	GSK2578215A is a potent and highly selective LRRK2 inhibitor,which exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.	price>
R-R-2778	Olcegepant hydrochloride CAS No.586368-06-1	Olcegepant hydrochloride (BIBN-4096 hydrochloride)/CAS No.586368-06-1 is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide receptor 1 (CGRP1) with IC50 of 0.03 nM and with a Ki of 14.4 pM for human CGRP.	price>
R-C-1079	Berzosertib (VE-822) CAS:1232416-25-9	VE-822 is an inhibitor of ataxia-telangiectasia mutated(ATM)Rad3-related protein kinase(ATR),a regulator of DNA damage repair, with Ki and IC50 values of <0.2 and 19 nM,respectively,in pancreatic cancer cells in vitro.1 It is selective for ATR over ATM (Ki=34 nM;IC50=2,600 nM) as well as DNA-PK,mTOR,and PI3Kγ(Kis= >4,000,>1,000,and 220 nM,respectively).In cultured COLO 205 colorectal cancer cells,VE-822(80 nM)reduces the IC50 of the topoisomerase 1 inhibitor SN-38 by at least 8-fold.2 In a mouse xenograft model,it delays the growth of radiation-treated PSN-1 pancreatic cancer xenografts by 2-3-fold relative to radiation alone when administered at a dose of 60 mg/kg.VE-822 also enhances the tumoricidal effects of cisplatin against primary human lung cancer xenografts and the effects of the topoisomerase inhibitor irinotecan against COLO 205 colorectal tumors in mice.	price>
R-R-2779	Telcagepant CAS No.781649-09-0	Telcagepant (MK-0974)/CAS No.781649-09-0 is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with Kis of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively.	price>
R-C-1080	VE821 CAS:1232410-49-9	VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.	price>
R-R-2780	BCTC CAS No.393514-24-4	BCTC/CAS No.393514-24-4 is an orally active current inhibitor of vanilloid receptor type 1 (VR1). BCTC is a transient receptor potential cation channel subfamily M member 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1) antagonist. BCTC is an insulin sensitizer and secretor. BCTC has anticancer and analgesic effects.	price>
R-C-1081	PI3065 CAS:955977-50-1	PI 3065 is a p110δ-selective PI3K inhibitor with Ki and IC50 values of 1.5 nM and 5 nM,respectively.Administration of PI 3065 suppressed 4T1 tumour growth and metastasis,to a similar extent as genetic inactivation of p110δ,marked by initial tumour progression,followed by tumour regression.	price>
R-R-2781	MK-3207 CAS No.957118-49-9	MK-3207/CAS No.957118-49-9 is an orally active, highly selective and species-specific CGRP receptor antagonist (for human CGRP receptor: IC50=0.12 nM; Ki=0.024 nM). MK-3207 can be used for migraine studies.	price>
R-C-1082	Ro 48-8071 fumarate CAS:89197-69-1	Ro 48-8071 blocked human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range;in cells it triggered the production of monooxidosqualene, dioxidosqualene,and epoxycholesterol.Administration of Ro 48-8071 to mice with BT-474 tumor xenografts prevented tumor growth,with no apparent toxicity.Ro 48-8071 degraded ERα while concomitantly inducing the anti-proliferative protein ERβ.	price>

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