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Catalog	name	Description	price
R-C-1097	Omaveloxolone (RTA-408) CAS:1474034-05-3	Omaveloxolone(RTA 408)is an antioxidant inflammation modulator(AIM),which activates Nrf2 and suppresses nitric oxide(NO).Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.	price>
R-R-2797	Urocortin III, mouse TFA	Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.	price>
R-C-1098	Resminostat CAS：864814-88-0	Resminostat,also known as RAS2410,is a potent inhibitor of histone deacetylase (HDAC)classes I and II.It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones.	price>
R-R-2798	CP 376395 CAS No.175140-00-8	CP 376395/CAS No.175140-00-8 is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist.	price>
R-C-1099	JNK Inhibitor IX CAS：312917-14-9	JNK Inhibitor IX is a thienylnaphthamide compound that is a selective and potent inhibitor of the ATP binding site of JNK2 and JNK3.JNK1,p38α and other kinases are effected slightly or not at all when JNK2 and JNK3 are inhibited by the JNK inhibitor IX.In comparison to SP600125(sc-200635),the inhibitor of JNK,JNK inhibitor IX is more selective between JNK1 and JNK3.The JNK pathway plays important roles in various cellular processes and is activated when cells are exposed to proinflammatory cytokines, environmental stress and different anticancer drugs.Research shows that JNK1,JNK2,and JNK3 are associated in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.	price>
R-R-2799	DMP 696 CAS No.202578-52-7	DMP 696/CAS No.202578-52-7 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.	price>
R-C-1100	Macitentan CAS：441798-33-0	Macitentan is an orally active,non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis(IPF)and pulmonary arterial hypertension(PAH).	price>
R-R-2800	Tildacerfont CAS No.1014983-00-6	Tildacerfont/CAS No.1014983-00-6 is a potent and orally active corticotrophin-releasing factor type 1 (CRF1) receptort antagonis. Tildacerfont effectively reduces adrenocorticotropic hormone (ACTH) and adrenal androgen levels. Tildacerfont has favourable safety profile. Tildacerfont can be used for researching congenital adrenal hyperplasia.	price>
R-C-1101	FK-3311 CAS：116686-15-8	FK-3311(COX-2 Inhibitor V)is a selective,cell-permeable and orally available inhibitor of cyclooxygenase-2(COX-2)with antiinflammatory.FK-3311 has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2.	price>
R-R-2801	Antalarmin CAS No.157284-96-3	Antalarmin/CAS No.157284-96-3 is a selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1) antagonist with a Ki of 2.7 nM. Antalarmin can pass through the blood–brain barrier.	price>
R-C-1102	4SC-101 CAS：717824-30-1	Vidofludimus is an orally bioavailable inhibitor of dihydroorotate dehydrogenase (DHODH),with potential anti-inflammatory,immunomodulating and anti-viral activities.Upon administration,vidofludimus specifically targets,binds to and prevents the activation of DHODH.This prevents the fourth enzymatic step in de novo pyrimidine synthesis,leading to inhibition of transcriptional elongation, cell cycle arrest,and apoptosis in activated lymphocytes.DHODH inhibition also leads to metabolic stress in activated lymphocytes and inhibition of the release of proinflammatory cytokines including interleukin (IL)-17(IL-17A and IL-17F) and interferon-gamma(IFNg),thereby reducing inflammation.In addition,DHODH inhibition may lead to host-based anti-viral activity against many viruses. DHODH,a mitochondrial enzyme that catalyzes the conversion of dihydroorotate (DHO) to orotate,is a key enzyme in pyrimidine de novo biosynthesis.	price>
R-R-2802	a-Helical CRF(9-41) TFA	α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM.	price>
R-C-1103	AL 082D06 CAS：256925-03-8	AL082D06 is a nonsteroidal glucocorticoid receptor(GR)antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids,androgens,estrogens,and progestins.	price>
R-R-2803	Urocortin, rat CAS No.171543-83-2	Urocortin, rat (Urocortin (Rattus norvegicus))/CAS No.171543-83-2 is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively.	price>
R-C-1104	Ixazomib (MLN2238 ) CAS: 1072833-77-2	Ixazomib(MLN2238)inhibits the chymotrypsin-like proteolytic(β5)site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively,also inhibits the caspase-like(β1)and trypsin-like(β2) proteolytic sites,with IC50 of 31 and 3500 nM.Ixazomib(MLN2238) induces autophagy.	price>
R-R-2804	NBI-27914 hydrochloride CAS No.1215766-76-9	NBI-27914 (hydrochloride)/CAS No.1215766-76-9 is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM.	price>
R-C-1105	LY2409881 CAS：946518-60-1	LY2409881 is a selective inhibitor of IκB kinase β(IKK2;IC50=30 nM).1 It inhibits IKK1 and other common kinases at≥10-fold higher concentrations.1 LY2409881 has been shown to suppress constitutively activated NF-κB and to induce apoptosis in lymphoma cells both in vitro and in preclinical mouse models of B and T cell lymphoma both as a single agent and in combination with histone deacetylase inhibitors.	price>
R-R-2805	Urotensin I TFA	Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.	price>
R-C-1106	PQ401 CAS：196868-63-0	PQ401 is an inhibitor of insulin-like growth factor 1 receptor(IGF-1R).1 It inhibits autophosphorylation of the recombinant IGF-1R kinase domain(IC50=<1 μM)in a cell-free assay as well as IGF-1-stimulated IGF-1R autophosphorylation in MCF-7 cells(IC50=12μM).PQ401 reduces cell viability of U87MG glioma cells with an IC50 value of 5 μM and induces apoptosis and inhibits cell migration in a concentration-dependent manner.2 It inhibits IGF-1-stimulated proliferation of MCF-7 cells in vitro(IC50=6μM)and reduces tumor growth in an MCNeuA model of murine breast cancer when administered at doses of 50 and 100 mg/kg.1 PQ401 also has antimalarial activity against the P.	price>
R-R-2806	Liraglutide CAS No.204656-20-2	Liraglutide/CAS No.204656-20-2 is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.	price>

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