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Catalog	name	Description	price
R-R-2782	MK-3207 Hydrochloride CAS No.957116-20-0	MK-3207 (Hydrochloride)/CAS No.957116-20-0 is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.	price>
R-C-1083	TORIN1 CAS：1222998-36-8	Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM.Torin 1 shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM,DNA-PK,and hVps34,as well as 450 other protein kinases.Torin 1 induces autophagy in HeLa cells.Torin 1 is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.In a recent study,it is reported Torin 1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.	price>
R-R-2783	Atogepant CAS No.1374248-81-3	Atogepant (MK-8031)/CAS No.1374248-81-3 is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.	price>
R-C-1084	LCL161 CAS:1005342-46-0	LCL161 enhanced the pro apoptotic effect of nilotinib and PKC412 on leukemia in vitro,and enhanced the activity of two kinase inhibitors on leukemia in vivo.In addition,LCL161 synergized with nilotinib in vivo and significantly reduced the burden of leukemia to below the baseline level of inhibition of medium and high dose nilotinib.Finally,LCL161 showed antiproliferative effect on the cells with inherent resistance to tyrosine kinase inhibitors,which was the result of the mutant expression of the compound inhibitory protein target.LCL161 is a small molecule antagonist of apoptosis inhibitor(IAP),with IC50 value of 10.23 μM.lcl161 in Hep3B cells could inhibit the proliferation and activity of Hep3B and PLC5 cells.Lcl161 also had effect on ALCL cell line karpas-299 with IC50 value of 1.6μM.	price>
R-R-2784	Adrenomedullin (1-50), rat	Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of CGRP1 receptor.	price>
R-C-1085	LY2584702 CAS：1082949-67-4	LY2584702 inhibits ribosomal protein S6 Kinase(p70S6K),and prevents phosphorylation of the S6 subunit of ribosomes,thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation.LY2584702 exhibited anti-tumour activity in preclinical analysis.	price>
R-R-2785	Calcitonin Gene Related Peptide (CGRP) II, rat TFA	Calcitonin Gene Related Peptide (CGRP) II, rat TFA, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II TFA can be used in the research of cardiovascular diseases.	price>
R-C-1086	CHIR99021 CAS:252917-06-9	CHIR-99021(CT99021)is a potent and selective GSK-3α/βinhibitor with IC50s of 10 nM and 6.7 nM.CHIR-99021 shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases.CHIR-99021 is also a potent Wnt/β-catenin signaling pathway activator.CHIR-99021 enhances mouse and human embryonic stem cells self-renewal.CHIR-99021 induces autophagy.	price>
R-R-2786	SUN B8155 CAS No.345893-91-6	SUN B8155/CAS No.345893-91-6, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis.	price>
R-C-1087	ACTB-1003 CAS：939805-30-8	ACTB-1003 is an oral kinase inhibitor targeting cancer mutations(FGFR inhibition),angiogenesis (inhibition of VEGFR2 and Tie-2)and induces apoptosis (targeting RSK and p70S6K,downstream of PI3 kinase).	price>
R-R-2787	Adrenomedullin (16-31), human CAS No.318480-38-5	Adrenomedullin (16-31), human/CAS No.318480-38-5 is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human possesses pressor activity in the systemic vascular bed of the rat, but not the cat.	price>
R-C-1088	RN486 CAS：1242156-23-5	RN486 is a potently and selectively inhibitor.RN486 inhibited the Btk enzyme and displayed functional activities in human cell-based assays in multiple cell types.RN486 blocks Fcε receptor cross-linking-induced degranulation in mast cells (IC(50)=2.9 nM),Fcγ receptor engagement-mediated tumor necrosis factor α production in monocytes(IC(50)=7.0 nM),and B cell antigen receptor-induced expression of an activation marker,CD69,in B cells in whole blood(IC(50)=21.0 nM).RN486 produced robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis(AIA) models.In the AIA model,RN486 inhibited both joint and systemic inflammation either alone or in combination with methotrexate,reducing both paw swelling and inflammatory markers in the blood.	price>
R-R-2788	Chrysin 6-C-glucoside 8-C-arabinoside CAS No.185145-34-0	Chrysin 6-C-glucoside 8-C-arabinoside/CAS No.185145-34-0 can inhibit the CGRP releasing and the activation of TRPV1 channel. Chrysin 6-C-glucoside 8-C-arabinoside can be used for anti-migraine research.	price>
R-C-1089	D4476 CAS:301836-43-1	D4476 is a relatively specific cell osmotic inhibitor of CK1 and ALK5 with IC50 values of 0.3 and 0.5,respectively μ In vitro,the phosphorylation of CK1 (casein kinase 1)was located at the serine residue near another phosphoserine in the multipoint phosphorylation domain(MPD).D4476 may be a competitive ATP inhibitor of CK1.In H4IIE cells,the site-specific phosphorylation of FOXO1a (ser322 and ser325)was inhibited at 50 and 125 μ M.The initial rate of nuclear repulsion is reduced.In HeLa cells,d4476 inhibited CK1 induced RhoB phosphorylation(ser185)at 50℃μ RhoB dependent actin fiber formation is then activated.D4476 treaCAS No.285986-88-1t resulted in partial p53 dependent growth arrest of HCT116 cells.	price>
R-R-2789	(3R,5R,6S)-Atogepant	(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) is the enantiomer of Atogepant (HY-109022). Atogepant is a calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.	price>
R-C-1090	CCG-1423 CAS：285986-88-1	CCG-1423 is a small-molecule inhibitor of RhoA transcriptional signaling.CCG-1423 potently(<1 mumol/L)inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells,and whereas it inhibits the growth of RhoC-overexpressing melanoma lines(A375M2 and SK-Mel-147)at nanomolar concentrations, it is less active on related lines(A375 and SK-Mel-28)that express lower levels of Rho.	price>
R-R-2790	R121919 CAS No.195055-03-9	R121919 (NBI30775)/CAS No.195055-03-9 is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats.	price>
R-C-1091	CP945598.HCl CAS：686347-12-6	CP 945598 hydrochloride(Otenabant HCl)is a potent and selective cannabinoid type 1 receptor antagonist that inhibits both basal and cannabinoid agonist-mediated CB(1)receptor signaling in vitro and in vivo.It displays low affinity for human CB2 receptors with Ki of 7600 nM. In vivo,CP-945598 reversed cannabinoid agonist-mediated responses,reduced food intake,and increased energy expenditure and fat oxidation in rodents.CP 945598 exhibits dose and concentration-dependent anorectic activity in two models of acute food intake in rodents,fast-induced re-feeding and spontaneous,nocturnal feeding.CP-945598 also acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation.	price>
R-R-2791	Verucerfont CAS No.885220-61-1	Verucerfont/CAS No.885220-61-1 is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.	price>
R-C-1092	Citarinostat (ACY-241) CAS：1316215-12-9	Citarinostat(ACY-241,HDAC-IN-2)is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3,respectively.It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.	price>

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