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Catalog	name	Description	price
R-R-2802	a-Helical CRF(9-41) TFA	α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM.	price>
R-C-1103	AL 082D06 CAS：256925-03-8	AL082D06 is a nonsteroidal glucocorticoid receptor(GR)antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids,androgens,estrogens,and progestins.	price>
R-R-2803	Urocortin, rat CAS No.171543-83-2	Urocortin, rat (Urocortin (Rattus norvegicus))/CAS No.171543-83-2 is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively.	price>
R-C-1104	Ixazomib (MLN2238 ) CAS: 1072833-77-2	Ixazomib(MLN2238)inhibits the chymotrypsin-like proteolytic(β5)site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively,also inhibits the caspase-like(β1)and trypsin-like(β2) proteolytic sites,with IC50 of 31 and 3500 nM.Ixazomib(MLN2238) induces autophagy.	price>
R-R-2804	NBI-27914 hydrochloride CAS No.1215766-76-9	NBI-27914 (hydrochloride)/CAS No.1215766-76-9 is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM.	price>
R-C-1105	LY2409881 CAS：946518-60-1	LY2409881 is a selective inhibitor of IκB kinase β(IKK2;IC50=30 nM).1 It inhibits IKK1 and other common kinases at≥10-fold higher concentrations.1 LY2409881 has been shown to suppress constitutively activated NF-κB and to induce apoptosis in lymphoma cells both in vitro and in preclinical mouse models of B and T cell lymphoma both as a single agent and in combination with histone deacetylase inhibitors.	price>
R-R-2805	Urotensin I TFA	Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.	price>
R-C-1106	PQ401 CAS：196868-63-0	PQ401 is an inhibitor of insulin-like growth factor 1 receptor(IGF-1R).1 It inhibits autophosphorylation of the recombinant IGF-1R kinase domain(IC50=<1 μM)in a cell-free assay as well as IGF-1-stimulated IGF-1R autophosphorylation in MCF-7 cells(IC50=12μM).PQ401 reduces cell viability of U87MG glioma cells with an IC50 value of 5 μM and induces apoptosis and inhibits cell migration in a concentration-dependent manner.2 It inhibits IGF-1-stimulated proliferation of MCF-7 cells in vitro(IC50=6μM)and reduces tumor growth in an MCNeuA model of murine breast cancer when administered at doses of 50 and 100 mg/kg.1 PQ401 also has antimalarial activity against the P.	price>
R-R-2806	Liraglutide CAS No.204656-20-2	Liraglutide/CAS No.204656-20-2 is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.	price>
R-C-1107	BMS794833 CAS：1174046-72-0	BMS-794833 is a potent ATP competitive inhibitor of Met(cMet)/VEGFR2 with IC50 of 1.7 nM/15 nM,also inhibits Ron,Axl and Flt3 with IC50 of <3 nM;a prodrug of BMS-817378.	price>
R-R-2807	NN1177 TFA	NN1177 (NNC9204-1177) TFA is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 TFA can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice.	price>
R-C-1108	ANA-12 CAS： 219766-25-3	ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites,respectively.	price>
R-R-2808	Emicerfont CAS No.786701-13-1	Emicerfont/CAS No.786701-13-1 is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.	price>
R-C-1109	ITD1 CAS:1099644-42-4	ITD 1 is an inhibitor of TGF-β(IC50=0.85 µM).It is selective for TGF-β in an SBE4/Smad reporter assay,providing 83% inhibition when used at a concentration of 2.5 µM,over activin A,which is inhibited by 51% when used at the same concentration.ITD 1 inhibits TGF-β signaling by induction of TGF-β receptor type II degradation.It stimulates differentiation of mouse embryonic stem cells (mESCs)into cardiomyocytes.	price>
R-R-2809	GLP-1(7-36), amide acetate CAS No.1119517-19-9	GLP-1(7-36), amide acetate/CAS No.1119517-19-9 is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.	price>
R-C-1110	MK0822 CAS：603139-19-1	Odanacatib is a potent,selective,and neutral inhibitor of cathepsin K(IC50s=0.2 and 1 nM for human and rabbit enzymes,respectively),a protease involved in osteoclastic bone resorption.It demonstrates high selectivity for cathepsin K over cathepsins B,L,and S.Formulations containing odanacatib reduce bone resorption,with lesser reductions in bone formation,resulting in increased bone mineral density.	price>
R-R-2810	Orforglipron CAS No.2212020-52-3	Orforglipron (LY3502970) (GLP-1 receptor agonist 1)/CAS No.2212020-52-3 is a GLP-1 receptor agonist extracted from patent WO2018056453A1, Compound 67.	price>
R-C-1111	Sunitinib (SU 11248) CAS：557795-19-4	Sunitinib(SU 11248)is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ,respectively.Sunitinib, an ATP-competitive inhibitor,effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.	price>
R-R-2811	MK 0893 CAS No.870823-12-4	MK 0893/CAS No.870823-12-4 is a potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM.	price>
R-C-1112	ML234 CAS: 1222800-79-4	ML-324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.	price>

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