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Catalog	name	Description	price
R-C-1091	CP945598.HCl CAS：686347-12-6	CP 945598 hydrochloride(Otenabant HCl)is a potent and selective cannabinoid type 1 receptor antagonist that inhibits both basal and cannabinoid agonist-mediated CB(1)receptor signaling in vitro and in vivo.It displays low affinity for human CB2 receptors with Ki of 7600 nM. In vivo,CP-945598 reversed cannabinoid agonist-mediated responses,reduced food intake,and increased energy expenditure and fat oxidation in rodents.CP 945598 exhibits dose and concentration-dependent anorectic activity in two models of acute food intake in rodents,fast-induced re-feeding and spontaneous,nocturnal feeding.CP-945598 also acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation.	price>
R-R-2791	Verucerfont CAS No.885220-61-1	Verucerfont/CAS No.885220-61-1 is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.	price>
R-C-1092	Citarinostat (ACY-241) CAS：1316215-12-9	Citarinostat(ACY-241,HDAC-IN-2)is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3,respectively.It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.	price>
R-R-2792	NBI-27914 CAS No.184241-44-9	NBI-27914/CAS No.184241-44-9 is a potent and selective antagonist of CRFR1. The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily.	price>
R-C-1093	SCR-1481 CAS:1174161-86-4	SCR-1481B1(c-Met inhibitor 2)is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor.	price>
R-R-2793	[DPro5] Corticotropin Releasing Factor, human, rat TFA	[DPro5] Corticotropin Releasing Factor, human, rat TFA is a selective corticotropin releasing factor/hormone R2 (CRH-R2)agonist. [DPro5] Corticotropin Releasing Factor, human, rat TFA fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat.	price>
R-C-1094	BMS-777607 (BMS 817378) CAS:1025720-94-8	BMS-777607(BMS 817378)is a Met-related inhibitor for c-Met,Axl,Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM,1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck,VEGFR-2,and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.	price>
R-R-2794	Stressin I TFA	Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist, Ki is 1.7 nM. Stressin I induces an increase in adrenocorticotropic hormone (ACTH) levels in rats.	price>
R-C-1095	TPT-260 Dihydrochloride CAS:2076-91-7	TPT-260 Dihydrochloride(NSC55712)is a thiophene thiourea derivative with molecule weight 260.00 in free base form;There is no formal name yet,we temporally call this molecule as TPT-260.	price>
R-R-2795	Pexacerfont CAS No.459856-18-9	Pexacerfont/CAS No.459856-18-9 is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor.	price>
R-C-1096	UNBS-5162 CAS: 956590-23-1	UNBS5162 is a pan-antagonist of CXCL chemokine expression with in vitro cytotoxic activity(IC50 range of 0.5-5 µM)against a range of human cancer cell lines including glioblastoma(Hs683 and U373MG),colorectal(HCT-15 and LoVo), non-small-cell lung(A549)and breast(MCF-7).	price>
R-R-2796	Antisauvagine-30 TFA	Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.	price>
R-C-1097	Omaveloxolone (RTA-408) CAS:1474034-05-3	Omaveloxolone(RTA 408)is an antioxidant inflammation modulator(AIM),which activates Nrf2 and suppresses nitric oxide(NO).Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.	price>
R-R-2797	Urocortin III, mouse TFA	Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.	price>
R-C-1098	Resminostat CAS：864814-88-0	Resminostat,also known as RAS2410,is a potent inhibitor of histone deacetylase (HDAC)classes I and II.It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones.	price>
R-R-2798	CP 376395 CAS No.175140-00-8	CP 376395/CAS No.175140-00-8 is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist.	price>
R-C-1099	JNK Inhibitor IX CAS：312917-14-9	JNK Inhibitor IX is a thienylnaphthamide compound that is a selective and potent inhibitor of the ATP binding site of JNK2 and JNK3.JNK1,p38α and other kinases are effected slightly or not at all when JNK2 and JNK3 are inhibited by the JNK inhibitor IX.In comparison to SP600125(sc-200635),the inhibitor of JNK,JNK inhibitor IX is more selective between JNK1 and JNK3.The JNK pathway plays important roles in various cellular processes and is activated when cells are exposed to proinflammatory cytokines, environmental stress and different anticancer drugs.Research shows that JNK1,JNK2,and JNK3 are associated in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.	price>
R-R-2799	DMP 696 CAS No.202578-52-7	DMP 696/CAS No.202578-52-7 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.	price>
R-C-1100	Macitentan CAS：441798-33-0	Macitentan is an orally active,non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis(IPF)and pulmonary arterial hypertension(PAH).	price>
R-R-2800	Tildacerfont CAS No.1014983-00-6	Tildacerfont/CAS No.1014983-00-6 is a potent and orally active corticotrophin-releasing factor type 1 (CRF1) receptort antagonis. Tildacerfont effectively reduces adrenocorticotropic hormone (ACTH) and adrenal androgen levels. Tildacerfont has favourable safety profile. Tildacerfont can be used for researching congenital adrenal hyperplasia.	price>

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