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Catalog	name	Description	price
R-C-2847	SIB 1508Y maleate CAS:192231-16-6	Potent neuronal nicotinic ACh receptor agonist(EC50 values are 1.8,5,9 and 23 nM for α4β2,α2β4,α4β4 and α3β4 receptors respectively).Improves cognitive function in a MPTP-induced model of Parkinson Is Disease in vivo.	price>
R-R-2847	GRA Ex-25 CAS No.307983-31-9	GRA Ex-25/CAS No.307983-31-9 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively.	price>
R-C-1148	Purvalanol A CAS： 212844	Purvalanol A is a potent CDK inhibitor,which effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.indicating that the activation of CDKs contributes to the c-Src transformation.Purvalanol A suppressed the c-Src activity as effectively as the Src-selective inhibitor PP2,and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2.Purvalanol A induced a strong G2-M arrest,whereas PP2 weakly acted on the G1-S transition.	price>
R-R-2848	Ecnoglutide CAS No.2459531-73-6	Ecnoglutide (XW003)/CAS No.2459531-73-6 is a long-acting, cAMP-biased glucagon-like peptide 1 (GLP-1) receptor agonist. Ecnoglutide can be used for research of T2DM and obesity.	price>
R-C-1149	temsirolimus (CCI-779) CAS：162635-04-3	Temsirolimus is an ester analog of rapamycin.Temsirolimus binds to and inhibits the mammalian target of rapamycin(mTOR),resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle.mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.	price>
R-R-2849	Volagidemab CAS No.1233956-13-2	Volagidemab/CAS No.1233956-13-2 is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D).	price>
R-C-1150	DY-131 CAS：95167-41-2	DY131,also known as GSK-9089,is a novel selective agonist at estrogen-related receptors ERRβ and ERRγ.DY131 could potentiate the ERRgamma-induced growth inhibition in LNCaP-ERRgamma and DU145-ERRgamma cells in a dose-dependent manner.ERRgamma may perform an antiproliferative or tumor-suppressing function in prostate cancer cells.	price>
R-R-2850	Survodutide TFA	Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.	price>
R-C-1151	Tafluprost CAS:209860-87-7	Tafluprost,also known as MK2452 and AFP-168,is a prostaglandin analogue used topically(as eye drops)to control the progression of glaucoma and in the management of ocular hypertension.It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.	price>
R-R-2851	Glucagon-like peptide 1 (1-37), human TFA	Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor.	price>
R-C-1152	SNG-1153 CAS：1446712-19-1	SNG-1153 is a modulator of estrogen receptor ER-alpha36.	price>
R-R-2852	Crotedumab CAS No.1452387-69-7	Crotedumab (REGN1193)/CAS No.1452387-69-7 is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes.	price>
R-C-1153	SU6656 cas:330161-87-0	SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase.SU6656 modulates CTGF(connective tissue growth factor)expression in an ERK-dependent manner.SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth,invasion and angiogenesis in vivo.	price>
R-R-2853	VU0453379 CAS No.1638646-27-1	VU0453379/CAS No.1638646-27-1 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM.	price>
R-C-1154	BS-181 CAS:1397219-81-6	BS-181 is a highly selective CDK inhibitor for CDK7 with an IC(50)of 21 nmol/L. Testing of other CDKs as well as another 69 kinases showed that BS-181 only inhibited CDK2 at concentrations lower than 1 micromol/L,with CDK2 being inhibited 35-fold less potently(IC(50) 880 nmol/L)than CDK7.In MCF-7 cells,BS-181 inhibited the phosphorylation of CDK7 substrates,promoted cell cycle arrest and apoptosis to inhibit the growth of cancer cell lines,and showed antitumor effects in vivo.	price>
R-R-2854	GLP-1R agonist 4 CAS No.2401894-26-4	GLP-1R agonist 4/CAS No.2401894-26-4 is a potent agonist of GLP-1R. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 4 has the potential for the research of diabetes (extracted from patent WO2019239319A1, compound 96).	price>
R-C-1155	PLX647 CAS: 873786-09-5	20pecific dual FMS and KIT kinase inhibitor,with IC50s of 28 and 16 nM, respectively.PLX647 shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR(IC50s=91 and 130 nM, respectively).	price>
R-R-2855	Exendin (5-39) CAS No.196109-27-0	Exendin (5-39)/CAS No.196109-27-0 is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats.	price>
R-C-1156	L-701,324 CAS:142326-59-8	L-701,324 is a potent and selective NMDA/glycine receptor antagonist.L-701,324 exhibits a beneficial action in the animal model of parkinsonian rigidity.Pre-treatment with L-701,324 improves pharmacosensitivity in a mouse kindling model.	price>
R-R-2856	HAEGTFTSD CAS No.926018-45-3	HAEGTFTSD/CAS No.926018-45-3 is a 9-residue peptide of human GLP-1 peptide or GLP-1(7-36), amide (HY-P0054A). GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretionin a glucose-dependant manner.	price>

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