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Catalog	name	Description	price
R-C-1167	Tideglusib (NP031112, NP-12) CAS：865854-05-3	Tideglusib(NP031112)is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3βWT(1 h preincubation)and GSK-3βC199A(1 h preincubation), respectively.	price>
R-R-2867	V-0219 hydrochloride CAS No.2922283-73-4	V-0219 hydrochloride (Compound 9)/CAS No.2922283-73-4 is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). V-0219 hydrochloride can be used for obesity-associated diabetes research.	price>
R-C-1168	Elesclomol (STA-4783) CAS： 488832-69-5	Elesclomol(STA-4783)is an oxidative stress inducer that induces cancer cell apoptosis.Elesclomol is a reactive oxygen species(ROS)inducer.Elesclomol shows antitumor activity against a broad range of cancer cell types.Elesclomol is also a highly lipophilic Cu2+-binding molecule.Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research.	price>
R-R-2868	Apraglutide TFA	Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum.	price>
R-C-1169	GW 627368 CAS： 439288-66-1	GW627368(GW627368X)is a novel,potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively.	price>
R-R-2869	(S)-V-0219 hydrochloride	(S)-V-0219 hydrochloride is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (S)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-1R. (S)-V-0219 hydrochloride is orally active and ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice.	price>
R-C-1170	cevipabulin CAS：849550-05-6	Cevipabulin(TTI-237),an antimicrotubule agent,is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity.With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site,and promotes the polymerization of tubulin into microtubules.	price>
R-R-2870	GLP-1 receptor agonist 11 CAS No.2784590-83-4	GLP-1 receptor agonist 11 (compound 3)/CAS No.2784590-83-4 is an agonist of GLP Receptor. GLP-1 receptor agonist 11 can be used in the study of diseases such as diabetes and non-alc. fatty liver disease.	price>
R-C-1171	LY2874455 CAS：1254473-64-7	LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM,2.6 nM,6.4 nM,and 6 nM for FGFR1,FGFR2,FGFR3,and FGFR4,respectively,and also inhibits VEGFR2 activity with IC50 of 7 nM.	price>
R-R-2871	(R)-V-0219 hydrochloride	(R)-V-0219 hydrochloride is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (R)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-1R.	price>
R-C-1172	BLU-9931 CAS：1538604-68-0	BLU9931 is a potent,highly selective,and irreversible fibroblast growth factor receptor 4(FGFR4)inhibitor with an IC50 of 3 nM and a Kd of 6 nM.BLU9931 has significant antitumor activity.	price>
R-R-2872	GLP-1 receptor agonist 10	GLP-1 receptor agonist 10 (compound 42) is an agonist of GLP Receptor. GLP-1 receptor agonist 10 inhibits food intake and reduces glucose excursion in mice. GLP-1 receptor agonist 10 can be used in the study of type 2 diabetes (T2DM) and obesity.	price>
R-C-1173	TP-0903 CAS：1341200-45-0	TP-0903 is a potent and selective AXL Inhibitor with IC50 of 27 nM.TP-0903 is highly effective in inducing apoptosis.	price>
R-R-2873	HAEGT CAS No.852155-81-8	HAEGT/CAS No.852155-81-8 is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity.	price>
R-C-1174	Luminespib(NVP-AUY922) CAS：747412-49-3	Luminespib(AUY-922,NVP-AUY922,VER-52296)is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays,weaker potency against the HSP90 family members GRP94 and TRAP-1,exhibits the tightest binding of any small-molecule HSP90 ligand.Luminespib(AUY-922,NVP-AUY922)effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition,autophagy and apoptosis.	price>
R-R-2874	3-Deoxyglucosone CAS No.4084-27-9	3-Deoxyglucosone (3-Deoxy-D-glucosone)/CAS No.4084-27-9 is a reactive intermediate of the Maillard reaction and the polyol pathway. 3-Deoxyglucosone rapidly reacts with protein amino groups to form advanced glycation end products (AGEs), such as imidazolone, it is the most specific AGE for 3-DG. 3-Deoxyglucosone synergizes with low glucose to potentiate GLP-1 secretion and is considered as a biomarker for diabetes.	price>
R-C-1175	SB590885 CAS：405554-55-4	SB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM,and has 11-fold greater selectivity for B-Raf over c-Raf,without inhibition to other human kinases.	price>
R-R-2875	Albiglutide fragment TFA	Albiglutide fragment (GLP-1 (7-36) analog) TFA is an active fragment of Albiglutide (7-36) and a glucagon-like peptide-1 (GLP-1) analog (a long-acting GLP-1 receptor agonist). Albiglutide is produced by the fusion of DPP-4 resistant GLP-1 dimer with the human albumin gene. Moreover, Albiglutide fragment TFA significantly reduces glycosylated hemoglobin (A1C) and is used in type 2 diabetes (T2D) studies.	price>
R-C-1176	MK1775 CAS：955365-80-7	Adavosertib is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity.Adavosertib selectively targets and inhibits WEE1,a tyrosine kinase that phosphorylates cyclin-dependent kinase 1(CDK1,CDC2)to inactivate the CDC2/cyclin B complex.Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.Unlike normal cells,most p53 deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells.	price>
R-R-2876	HAEGTFTSDVSSYLE CAS No.926018-57-7	HAEGTFTSDVSSYLE/CAS No.926018-57-7 is a polypeptide from patent CN 102920658 B. GLP-I analog contains the sequence.	price>

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