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Catalog	name	Description	price
R-R-2901	NB001 CAS No.686301-48-4	NB001 (HTS 09836)/CAS No.686301-48-4 is an adenylcyclase 1 (AC1) inhibitor which has effect on neural and non-neural pain by modulating AC1 activity.	price>
R-C-1202	MMAE CAS:474645-27-7	Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization.1 Monomethyl Auristatin E(MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity.It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity.2,3 MMAE is typically coupled to the antibody via a protease-cleavable linker,allowing separation of the drug from the antibody following intracellular localization.	price>
R-R-2902	Adenylyl cyclase type 2 agonist-1 CAS No.2414908-52-2	Adenylyl cyclase type 2 agonist-1 (Compound 73)/CAS No.2414908-52-2 is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC50 of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases.	price>
R-C-1203	STF-31 CAS:724741-75-7	Glucose transporter 1(Glut1)is an inducible carrier of pentoses and hexoses, including glucose.STF-31 is an inhibitor of Glut1(IC50=~1 µM)that blocks glucose uptake.It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene,which overexpress Glut1.1 Although STF-31 binds Glut1, suggesting a direct effect,STF-31 also inhibits nicotinamide phosphoribosyltransferase,an enzyme that induces Glut1 expression.STF-31 is also toxic to human pluripotent stem cells(hPSCs)and can be used to selectively eliminate hPSCs from mixed cultures.	price>
R-R-2903	Small Cardioactive Peptide B (SCPB) CAS No.84746-43-0	Small Cardioactive Peptide B (SCPB)/CAS No.84746-43-0, a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.	price>
R-C-1204	Ostarine(MK2286) CAS:841205-47-8	Ostarine(GTx-024,MK-2866)is a selective androgen receptor modulator (SARM)with Ki of 3.8 nM,and is tissue-selective for anabolic organs.	price>
R-R-2904	Albanin A CAS No.73343-42-7	Albanin A/CAS No.73343-42-7, a flavonoid, suppresses glutamate release by decreasing Ca2+/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.	price>
R-C-1205	Glycochenodeoxycholic acid CAS:640-79-9	Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis.	price>
R-R-2905	Angiopeptin TFA CAS No.2478421-60-0	Angiopeptin TFA/CAS No.2478421-60-0, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research.	price>
R-C-1206	OTX015 CAS:202590-98-5	Birabresib(OTX015,MK 8628)is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2,BRD3,and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3(NSD3)target genes.	price>
R-R-2906	AC1-IN-1 CAS No.2762422-55-7	AC1-IN-1/CAS No.2762422-55-7 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity.	price>
R-C-1207	AZD2461 CAS:1174043-16-3	AZD-2461 is a potent PARP inhibitor,with IC50s of 5 nM,2 nM and 200 nM for PARP1,PARP2 and PARP3,respectively.	price>
R-R-2907	ML221 CAS No.877636-42-5	ML221/CAS No.877636-42-5 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.	price>
R-C-1208	Epacadostat (INCB 024360) CAS:1204669-58-8	Epacadostat(INCB 024360)is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1)inhibitor with an IC50 of 71.8 nM.	price>
R-R-2908	Abaloparatide TFA	Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis.	price>
R-C-1209	IWR-1-endo CAS:1127442-82-3	IWR-1-endo(endo-IWR 1)is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A,induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.	price>
R-R-2909	ML339 CAS No.2579689-83-9	ML339/CAS No.2579689-83-9 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 antagonizes β-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC50 of 0.3 μM and 1.4 μM, respectively. ML339 has no inhibitory effect on CXCR5，CXCR4，CXCR6 and apelin receptor (APJ), with IC50 >79 μM. ML339 has the potential to promote the development of prostate cancer research.	price>
R-C-1210	Marimastat CAS:154039-60-8	Marimastat(BB2516)is a broad spectrum and orally bioavailable inhibitor of MMPs,with potent activity against MMP-9(IC50=3nM),MMP-1(IC50=5nM),MMP-2 (IC50=6nM),MMP-14(IC50=9nM)and MMP-7(IC50=13 nM),used in the treatment of cancer.Marimastat(BB2516)is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels.As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.	price>
R-R-2910	Elabela(19-32) TFA	Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart.	price>
R-C-1211	SU-5614 CAS:1055412-47-9	SU5614 is a potent and selective FLT3 inhibitor.SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand(FL)in FL-dependent cells.	price>

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