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Catalog	name	Description	price
R-R-2911	TRV-120027 TFA	TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling. TRV120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the acute decompensated heart failure (ADHF) treatment.	price>
R-C-1212	oltipraz CAS：64224-21-1	Oltipraz has an inhibitory effect on HIF-1αactivation in a time-dependent manner,completely abrogating HIF-1αinduction at≥10μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM.Oltipraz is a potent Nrf2 activator.	price>
R-R-2912	UNC9994 hydrochloride CAS No.2108826-33-9	UNC9994 hydrochloride/CAS No.2108826-33-9 is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity.	price>
R-C-1213	S1RA CAS：878141-96-9	S1RA(E-52862)is a potent and selective sigma-1 receptor(σ1R,Ki=17nM) antagonist,showed good selectivity against σ2R(Ki>1000 nM).	price>
R-R-2913	TRV-120027 CAS No.1234510-46-3	TRV120027/CAS No.1234510-46-3, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment.	price>
R-C-1214	Balicatib(AAE-581) CAS No. 354813-19-7	Balicatib(AAE-581)is a potent and selective inhibitor of cathepsin K;10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B,L,and S.	price>
R-R-2914	(Rac)-Tavapadon CAS No.1643462-64-9	(Rac)-Tavapadon ((Rac)-PF-06649751)/CAS No.1643462-64-9 is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM). (Rac)-Tavapadon has antiparkinsonian activity.	price>
R-C-1215	Inauhzin(INZ) CAS：309271-94-1	Inauhzin is a potent SIRT inhibitor,which effectively reactivates p53 by inhibiting SIRT1 activity,promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.	price>
R-R-2915	7-Fluorotryptamine hydrochloride CAS No.159730-09-3	7-Fluorotryptamine hydrochloride/CAS No.159730-09-3 is a potent agonist of GPRC5A. 7-Fluorotryptamine hydrochloride induces GPRC5A-mediated β-arrestin recruitment. 7-Fluorotryptamine hydrochloride can be used for research of immune and cancer signaling.	price>
R-C-1216	Walrycin B CAS:878419-78-4	Walrycin B is a potent WalR inhibitor.The WalK/WalR(YycG/YycF)two-component system,which is essential for cell viability,is highly conserved and specific to low-GC percentage of Gram-positive bacteria,making it an attractive target for novel antimicrobial compounds.	price>
R-R-2916	CCX-777 CAS No.1226686-36-7	CCX-777/CAS No.1226686-36-7 is a partial agonist of β-arrestin-2 recruitment to ACKR3 (atypical chemokine receptor 3).	price>
R-C-1217	TPT-260 CAS NO. 769856-81-7	TPT-260(TPU260)is a thiophene thiourea derivative with molecule weight 260.00 in free base form;There is no formal name yet,we temporally call this molecule as TPT-260.	price>
R-R-2917	ML192 CAS No.460331-61-7	ML192/CAS No.460331-61-7 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, ERK1/2 phosphorylation and PKCβII translocation.	price>
R-C-1218	Altiratinib CAS:1345847-93-9	Altiratinib,also known as DCC-270,DP-5164,is an oral,selective and highly potent inhibitor of MET,TIE2,VEGFR2 and TRK kinases with potential anticancer activity.DCC-2701 effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling,cell growth and migration as compared with a HGF antagonist in vitro. Importantly,DCC-2701 is anti-proliferative activity was dependent on c-MET activation induced by stromal human fibroblasts and to a lesser extent exogenous HGF.	price>
R-R-2918	ELA-21 (human) CAS No.2245073-05-4	ELA-21 (human)/CAS No.2245073-05-4 is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways.	price>
R-C-1219	CTX0294885 CAS:1439934-41-4	CTX-0294885 is a novel broad-spectrum kinase inhibitor.CTx-0294885 exhibits inhibitory activity against a broad range of kinases in vitro.	price>
R-R-2919	GPR35 agonist 2 CAS No.494191-73-0	GPR35 agonist 2 (compound 11)/CAS No.494191-73-0 is a potent agonist of GPR35, with EC50s of 26 and 3.2 nM in the β-arrestin and Ca2+ release assay, respectively.	price>
R-C-1220	TH588 CAS：1609960-31-7	TH588 is a potent and selective MTH1(NUDT1)inhibitor with IC50 of 5 nM.It has no relevant inhibition of any of the other tested proteins at 100 μM,although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes,GPCRs,kinases,ion channels and transporters at 10 μM.	price>
R-R-2920	CB1R Allosteric modulator 3 CAS No.2633686-36-7	CB1R Allosteric modulator 3/CAS No.2633686-36-7 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively.	price>
R-C-1221	TH287 CAS：1609960-30-6	TH287 is a potent and selective inhibitor of MTH1,with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1,with no relevant inhibition of MTH2, NUDT5,NUDT12,NUDT14,NUDT16,dCTPase,dUTPase and ITPA at 100 μM.TH287 could act as a chemotherapeutic agent for cancer research.	price>

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