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Catalog	name	Description	price
R-C-1217	TPT-260 CAS NO. 769856-81-7	TPT-260(TPU260)is a thiophene thiourea derivative with molecule weight 260.00 in free base form;There is no formal name yet,we temporally call this molecule as TPT-260.	price>
R-R-2917	ML192 CAS No.460331-61-7	ML192/CAS No.460331-61-7 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, ERK1/2 phosphorylation and PKCβII translocation.	price>
R-C-1218	Altiratinib CAS:1345847-93-9	Altiratinib,also known as DCC-270,DP-5164,is an oral,selective and highly potent inhibitor of MET,TIE2,VEGFR2 and TRK kinases with potential anticancer activity.DCC-2701 effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling,cell growth and migration as compared with a HGF antagonist in vitro. Importantly,DCC-2701 is anti-proliferative activity was dependent on c-MET activation induced by stromal human fibroblasts and to a lesser extent exogenous HGF.	price>
R-R-2918	ELA-21 (human) CAS No.2245073-05-4	ELA-21 (human)/CAS No.2245073-05-4 is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways.	price>
R-C-1219	CTX0294885 CAS:1439934-41-4	CTX-0294885 is a novel broad-spectrum kinase inhibitor.CTx-0294885 exhibits inhibitory activity against a broad range of kinases in vitro.	price>
R-R-2919	GPR35 agonist 2 CAS No.494191-73-0	GPR35 agonist 2 (compound 11)/CAS No.494191-73-0 is a potent agonist of GPR35, with EC50s of 26 and 3.2 nM in the β-arrestin and Ca2+ release assay, respectively.	price>
R-C-1220	TH588 CAS：1609960-31-7	TH588 is a potent and selective MTH1(NUDT1)inhibitor with IC50 of 5 nM.It has no relevant inhibition of any of the other tested proteins at 100 μM,although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes,GPCRs,kinases,ion channels and transporters at 10 μM.	price>
R-R-2920	CB1R Allosteric modulator 3 CAS No.2633686-36-7	CB1R Allosteric modulator 3/CAS No.2633686-36-7 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively.	price>
R-C-1221	TH287 CAS：1609960-30-6	TH287 is a potent and selective inhibitor of MTH1,with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1,with no relevant inhibition of MTH2, NUDT5,NUDT12,NUDT14,NUDT16,dCTPase,dUTPase and ITPA at 100 μM.TH287 could act as a chemotherapeutic agent for cancer research.	price>
R-R-2921	ELA-11(human) CAS No.1784687-32-6	ELA-11(human)/CAS No.1784687-32-6, a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment.	price>
R-C-1222	GS967 CAS：1262618-39-2	GS967 is a novel,potent,and selective inhibitor of cardiac late sodium current(late INa);inhibits ATX-II-induced late I(Na)in ventricular myocytes and isolated hearts with IC(50)values of 0.13 and 0.21 uM,respectively.	price>
R-R-2922	GRK6-IN-1 CAS No.2677786-61-5	GRK6-IN-1 (compound 18)/CAS No.2677786-61-5 is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma.	price>
R-C-1223	MHY1485 CAS：326914-06-1	MHY1485 is a mTOR activator;inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.	price>
R-R-2923	GRK5-IN-2 CAS No.1642839-27-7	GRK5-IN-2 (compound 707)/CAS No.1642839-27-7, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research.	price>
R-C-1224	ELR510444 CAS：1233948-35-0	ELR510444 is a novel microtubule disruptor;inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM;not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines.	price>
R-R-2924	CCG258208 hydrochloride	CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM) while maintaining 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM), PKA, and ROCK1. CCG258208 hydrochloride can be used in heart failure research.	price>
R-C-1225	AG-221 CAS:1446502-11-9	Enasidenib is an oral,potent,reversible,selective inhibitor of the IDH2 mutant enzymes,with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K,respectively.	price>
R-R-2925	GRK6-IN-2 CAS No.2677786-27-3	GRK6-IN-2 (compound 10a)/CAS No.2677786-27-3 is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma.	price>
R-C-1226	DBPR211 Cas:1429239-98-4	CB1-IN-1(also known as DBPR211)is a novel,potent,peripherally restricted antagonist of the CB1R(cannabinoid 1 receptor)with Ki values of 0.3 nM and 21 nM for CB1R(EC50 of 3 nM)and CB2R,respectively.CB1-IN-1 has shown significant weight-loss effects and can decrease hepatic steatosis as well as insulin resistance in a diet-induced obese mice model.Therefore,it has great potential to be used in this related metabolic syndrome such as obesity.It also has favorable PK profiles including an extremely low brain to plasma ratio suggesting a low probability to cross BBB.	price>
R-R-2926	CCG273441 CAS No.2750414-35-6	CCG273441/CAS No.2750414-35-6 is a covalent inhibitor of G protein-coupled receptor (GPCR) kinase 5 (GRK5) with an IC50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC50=4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle.	price>

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