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Catalog	name	Description	price
R-C-1227	G007-LK CAS :1380672-07-0	G007-LK is a potent and selective inhibitor of TNKS1 and TNKS2,with IC50s of 46 nM and 25 nM,respectively.	price>
R-R-2927	KR-39038 CAS No.2770300-35-9	KR-39038/CAS No.2770300-35-9 is an orally active and potent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 0.02 μM. KR-39038 significantly inhibits angiotensin II-induced cellular hypertrophy through suppression of HDAC5 pathway in neonatal cardiomyocytes. KR-39038 shows profound anti-hypertrophic effects and improved cardiac function. KR-39038 can be used for heart failure research.	price>
R-C-1228	KU60019 CAS: 925701-49-1	KU-60019 is an improved analogue of KU-55933,with IC50 of 6.3 nM for ATM in cell-free assays,270-and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.	price>
R-R-2928	GRK2i TFA	GRK2i TFA is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. GRK2i TFA corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.	price>
R-C-1229	GSK8573 CAS :1693766-04-9	GSK8573(compound 23)is an inactive control compound for GSK2801.GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy.	price>
R-R-2929	Lificiguat CAS No.170632-47-0	Lificiguat/CAS No.170632-47-0 binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO.	price>
R-C-1230	SAR405838 (MI-773) CAS:1303607-60-4	SAR405838 is a highly potent and selective MDM2 inhibitor,binds to MDM2 with Ki= 0.88 nM and has high specificity over other proteins.	price>
R-R-2930	Vericiguat CAS No.1350653-20-1	Vericiguat (BAY1021189)/CAS No.1350653-20-1 is a potent, orally available and soluble guanylate cyclase stimulator.	price>
R-C-1231	10058-F4 CAS No. 403811-55-2	10058-F4 is a potent and selective c-Myc inhibitor,which markedly increases valproic acid-induced cell death in Jurkat and CCRF-CEM T-lymphoblastic leukemia cells.10058-F4 inhibits proliferation,downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells.10058-F4 induces cell-cycle arrest,apoptosis,and myeloid differentiation of human acute myeloid leukemia.	price>
R-R-2931	Linaclotide CAS No.851199-59-2	Linaclotide/CAS No.851199-59-2 is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.	price>
R-C-1232	Lomeguqtrib CAS:192441-08-0	Lomeguatrib,also known as PaTrin-2,is a potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase.Lomeguatrib is also a nontoxic low-molecular weight pseudosubstrate that has the ability to inactivate MGMT.Lomeguatrib can be used with temozolomide(TMZ)for GBM treatment.	price>
R-R-2932	Cinaciguat CAS No.329773-35-5	Cinaciguat/CAS No.329773-35-5 is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.	price>
R-C-1233	AZD1981 CAS:802904-66-1	AZD1981is an orally available selective CRTH or DP2 antagonist currently in clinical development for asthma.AZD1981 blocks functional responses in eosinophils,Th2 cells and basophils.AZD1981 displaced radio-labelled PGD2 from human recombinant DP2 with high potency(pIC50=8.4).Binding was reversible,non-competitive and highly selective against a panel of more than 340 other enzymes and receptors,including DP1(>1000-fold selective).AZD1981 inhibited DP2-mediated shape change and CD11b up-regulation in human eosinophils,shape change in basophils and chemotaxis of human eosinophils and Th2 cells with similar potency.AZD1981 exhibited good cross-species binding activity against mouse,rat,guinea pig,rabbit and dog DP2.Evaluation in mouse,rat or rabbit cell systems was not possible as they did not respond to DP2 agonists.Agonist responses were seen in guinea pig and dog, and AZD1981 blocked DP2-mediated eosinophil shape change.Such responses were more robust in the guinea pig,where AZD1981 also blocked DP2 -dependent eosinophil emigration from bone marrow.	price>
R-R-2933	ODQ CAS No.41443-28-1	ODQ/CAS No.41443-28-1 is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells.	price>
R-C-1234	Blonanserin CAS:132810-10-7	Blonanserin(AD-5423)is a potent and orally active 5-HT2A(Ki=0.812 nM) and dopamine D2 receptor(Ki=0.142nM)antagonist.Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of extrapyramidal symptoms,excessive sedation,or hypotension.	price>
R-R-2934	BAY 41-2272 CAS No.256376-24-6	BAY 41-2272/CAS No.256376-24-6 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research.	price>
R-C-1235	BRD73954 CAS:1440209-96-0	BRD73954 is a small molecule inhibitor that potently inhibits HDAC6 and HDAC8. It inhibits HDAC6,a class IIb histone that deacetylates cytoplasmic proteins, including tubulin,heat shock protein 90,and cortactin,and has roles in cell adhesion and motility.It is also an inhibitor of HDAC8,a class I histone that primarily targets nuclear proteins,including histones and cohesins,and regulates gene expression.	price>
R-R-2935	BAY 60-2770 CAS No.1027642-43-8	BAY 60-2770/CAS No.1027642-43-8 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.	price>
R-C-1236	STF-118804 CAS: 894187-61-2	STF 118804 is a highly specific NAMPT inhibitor that reduces the viability of most B-ALL cell lines with high potency IC50 values in the low nanomolar range and improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia.	price>
R-R-2936	Runcaciguat CAS No.1402936-61-1	Runcaciguat/CAS No.1402936-61-1 is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists.	price>

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