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Catalog	name	Description	price
R-R-2986	PROTAC K-Ras Degrader-1 CAS No.2378258-52-5	PROTAC K-Ras Degrader-1 (Compound 518)/CAS No.2378258-52-5 is a PROTAC. PROTAC K-Ras Degrader-1 can effectively degrades K-Ras based on Cereblon E3 ligand, exhibits ≥70% degradation efficacy in SW1573 cells.	price>
R-C-1287	YK11 CAS：1370003-76-1	YK-11 is a synthetic,steroidal selective androgen receptor modulator(SARM).It is a gene-selective partial agonist of the androgen receptor(AR)and does not induce the physical interaction between the NTD/AF1 and LBD/AF2(known as the N/C interaction),which is required for full transactivation of the AR.The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone(DHT)in this regard.	price>
R-R-2987	ML-099 CAS No.496775-95-2	ML-099 (CID-888706)/CAS No.496775-95-2 is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A.	price>
R-C-1288	Ibutamoren (MK-677) CAS：159634-47-6	Ibutamoren,also known as MK-677(L-163,191),is a drug which acts as a potent, orally active growth hormone secretagogue,mimicking the GH stimulating action of the endogenous hormone ghrelin.	price>
R-R-2988	Digeranyl bisphosphonate CAS No.878143-03-4	Digeranyl bisphosphonate (DGBP)/CAS No.878143-03-4 is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1.	price>
R-C-1289	Entospletinib (GS-9973) CAS：1229208-44-9	Entospletinib,also known as GS-9973,is a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications.In Phase II clinical trials,Entospletinib demonstrates clinical activity in subjects with relapsed or refractory CLL with acceptable toxicity.	price>
R-R-2989	Pan KRas-IN-1 CAS No.2791263-84-6	Pan KRas-IN-1/CAS No.2791263-84-6 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors.	price>
R-C-1290	Filgotinib (GLPG0634) CAS：1206161-97-8	Filgotinib,also known as GLPG0634,is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis(RA)and Crohn is disease.It is considered a promising agent as it inhibits JAK1 selectively. Filgotinib displayed a selectivity of 30-fold for JAK1-over JAK2-dependent signaling.GLPG0634 dose-dependently inhibited Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro.	price>
R-R-2990	BQU57 CAS No.1637739-82-2	BQU57/CAS No.1637739-82-2 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA. The IC50 for BQU57 of 2.0 μM in H2122 and 1.3 μM in H358.	price>
R-C-1291	Fimepinostat (CUDC-907) CAS：1339928-25-4	Fimepinostat(CUDC-907)potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10,respectively.	price>
R-R-2991	CCG-203971 CAS No.1443437-74-8	CCG-203971/CAS No.1443437-74-8 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC50 =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC50 of 4.2 μM. Potential anti-metastasis Agent.	price>
R-C-1292	Vacquinol-1 CAS# 5428-80-8	Vacquinol-1,also known as NSC 13316,is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.Vacquinol-1 has beneficial effects on a glioblastoma multiforme mouse model by oral administration.In glioblastoma cells,Vacquinol-1 targets macropinocytosis,a cellular process that will not lead to cell death in normal cells.	price>
R-R-2992	Rasarfin CAS No.674359-73-0	Rasarfin/CAS No.674359-73-0 is a dual Ras and ARF6 inhibitor.	price>
R-C-1293	NS 11021 CAS:956014-19-0	NS-11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa,KCa1.1).BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.NS11021 enhances erectile responses in rats.	price>
R-R-2993	CE3F4 CAS No.143703-25-7	CE3F4/CAS No.143703-25-7 is a selective antagonist of exchange protein directly activated by cAMP (Epac1), with IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.	price>
R-C-1294	KO143 CAS:461054-93-3	Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP)inhibitor.Ko 143 displays>200-fold selectivity over P-gp and MRP-1 transporters.	price>
R-R-2994	RMC-0331 CAS No.2488788-52-7	RMC-0331 (RM-023)/CAS No.2488788-52-7 is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.	price>
R-C-1295	BAZ2-ICR CAS:1665195-94-7	BAZ2-ICR is an excellent chemical probe for functional studies of the BAZ2 bromodomains in vitro and in vivo.The bromodomain containing proteins BAZ2A/B play essential roles in chromatin remodeling and regulation of noncoding RNAs. BAZ2-ICR has IC50(BAZ2A)=130 nM;IC50(BAZ2B)=180 nM;logD=1.05;solubility 25 mM (D2O)and F=70%.	price>
R-R-2995	RAS inhibitor Abd-7 CAS No.2351843-48-4	RAS inhibitor Abd-7/CAS No.2351843-48-4, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V.	price>
R-R-2996	RM-018 CAS No.2641993-55-5	RM-018/CAS No.2641993-55-5 is a potent, functionally distinct tricomplex KRASG12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRASG12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [“RAS(ON)”] state of KRASG12C.	price>

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