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Catalog	name	Description	price
R-C-1327	FIPI CAS：939055-18-2	FIPI is a derivative of halopemide which potently inhibits both PLD1 and PLD2 with IC50s of 25 nM and 20 nM,respectively.	price>
R-R-3027	SOS1-IN-15 CAS No.2793404-47-2	SOS1-IN-15 (Compound 37)/CAS No.2793404-47-2 is an orally active SOS1 inhibitor with an IC50 of 5 nM. SOS1-IN-15 is a promising agent candidate for the research of KRAS-driven cancer.	price>
R-C-1328	Onatasertib (CC 223) CAS：1228013-30-6	Onatasertib,also known as CC-223,is an orally available inhibitor of the mammalian target of rapamycin(mTOR)with potential antineoplastic activity.mTOR kinase inhibitor CC-223 inhibits the activity of mTOR,which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR,a serine/threonine kinase that is upregulated in a variety of tumors,plays an important role downstream in the PI3K/AKT/mTOR signaling pathway,which is frequently dysregulated in human cancers.	price>
R-R-3028	BI-0474 CAS No.2750570-55-7	BI-0474/CAS No.2750570-55-7 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.	price>
R-R-3029	Rac1 Inhibitor W56 TFA	Rac1 Inhibitor W56 TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 TFA inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam.	price>
R-C-1330	MCC950 sodium（CP-456773 sodium; CRID3 sodium salt） CAS No. : 256373-96-3	MCC950 sodium(CP-456773 sodiumCRID3 sodium salt)is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.	price>
R-R-3030	Kobe2602 CAS No.454453-49-7	Kobe2602/CAS No.454453-49-7 is a Ras-Raf interaction inhibitor. Kobe2602 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki of 149 μM. Kobe2602 has antitumor activity.	price>
R-C-1331	Isoxazole 9 (ISX-9) CAS:832115-62-5	Isoxazole 9(Isx-9)is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells(NSPCs).Isoxazole 9(Isx-9)activates multiple pathways including TGF-βinduced epithelial–mesenchymal transition(EMT)signaling,canonical and non-canonical Wnt signaling at different stages of cardiac differentiation.	price>
R-R-3031	SOS1-IN-14 CAS No.2793405-20-4	SOS1-IN-14/CAS No.2793405-20-4 is a potent, selective and orally active SOS1 inhibitor with an IC50 value of 3.9 nM. SOS1-IN-14 can be absorbed in the intestine via a P-glycoprotein-mediated efflux mechanism. SOS1-IN-14 can be used to research KRAS-mutated cancers. SOS1-IN-14 has better potent tumor suppression than BI-3406 (HY-125817).	price>
R-C-1332	JH-II127 CAS:1700693-08-8	JH-II-127 is a highly potent,selective,and brain penetrant LRRK2 inhibitor,with IC50 of 6.6 nM,2.2 nM,47.7 nM for LRRK2-wild-type,LRRK2-G2019S,LRRK2-A2016T.	price>
R-R-3032	K-Ras G12C-IN-4 CAS No.2376328-55-9	K-Ras G12C-IN-4/CAS No.2376328-55-9, compound 1, is a potent Covalent Inhibitor of KRASG12C.	price>
R-C-1333	NIBR189 CAS:1599432-08-2	NIBR-189 is a potent and selective EBI2(GPR183)receptor antagonist(IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively).NIBR-189 blocks migration of a monocyte cell line called U937,suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.	price>
R-R-3033	KRAS G12C inhibitor 14 CAS No.2349393-95-7	KRAS G12C inhibitor 14/CAS No.2349393-95-7 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM.	price>
R-C-1334	MSX122 CAS：897657-95-3	MSX-122 is an orally bioavailable inhibitor of CXCR4(IC50=10 nM)with potential antineoplastic and antiviral activities.CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4,preventing the binding of stromal derived factor-1 (SDF-1)to the CXCR4 receptor and receptor activation,which may result in decreased tumor cell proliferation and migration.	price>
R-R-3034	RMC-4998 CAS No.2642037-07-6	RMC-4998/CAS No.2642037-07-6 is a molecular glue compound with good antitumor activity. RMC-4998 is able to form a ternary complex with CYPA and an activated KRAS G12C mutant. Furthermore, CYPA binding to KRAS G12C blocks the interaction between activated KRAS mutants and downstream effector proteins, thereby inhibiting signaling that promotes cell proliferation.	price>
R-C-1335	XY1 CAS：1624117-53-8	XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 µM.SGC707 is a potent,selective allosteric inhibitor of PRMT3(IC50=50nM).It inhibits the methylation of histones in cells with an IC50 value below 1 µM.	price>
R-R-3035	6H05 TFA CAS No.2061344-88-3	6H05 TFA/CAS No.2061344-88-3 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).	price>
R-C-1336	PS-1145 CAS：431898-65-6	PS-1145 is a selective IκB kinase(IKK)inhibitor(IC50100 nM).PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells.PS1145 induced caspase 3/7-dependent apoptosis in PC cells and significantly sensitized PC cells to apoptosis induced by tumor necrosis factor alpha.PS1145 inhibited PC cell proliferation.PS1145 enhances apoptosis in DMBA-induced tumor in male Wistar rats.	price>
R-R-3036	Nexinhib20 CAS No.331949-35-0	Nexinhib20/CAS No.331949-35-0 is a specific Rab27a-JFC1 interaction inhibitor with a calculated IC50 of 2.6 μM. Nexinhib20 significantly inhibits superoxide anion production. Nexinhib20 efficiently decreases exocytosis of azurophilic granules in neutrophils stimulated with fMLP, GM-CSF or both. Nexinhib20 has a significant anti-inflammatory activity.	price>
R-C-1337	FPH2(BRD9424) CAS：957485-64-2	FPH2(BRD-9424)is an inducer of proliferation of primary human hepatocytes.In vitro,FPH2 induced functional proliferation of hepatocytes and might be useful for expanding mature human primary hepatocytes.FPH2(40μM)increased the area of hepatocyte colonies with more hepatocytes and Ki67-positive nuclei,which exhibited hepatocyte nuclear morphologies.In primary human hepatocytes from six additional cell sources,FPH2 increased hepatocytes expansion.FPH2 increased hepatocyte at a rate that is consistent with liver regeneration kinetics in vivo .	price>

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