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Catalog	name	Description	price
R-R-3055	PHT-7.3 CAS No.1614225-93-2	PHT-7.3/CAS No.1614225-93-2 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity.	price>
R-C-1356	Ro 61-8048 CAS No. 199666-03-0	Ro61-8048 is a potent Kynurenine hydroxylase inhibitor(Ki=4.8 nM,IC50=37nM).Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.Ro 61-8048 may be potentially useful for the treatment of dyskinesias.Ro 61-8048 could be a new avenue to reduce neuronal loss in brain ischemia.	price>
R-R-3056	SOS1-IN-11 CAS No.2654741-64-5	SOS1-IN-11/CAS No.2654741-64-5 is a potent SOS1 inhibitor with an IC50 value of 30 nM.	price>
R-C-1357	AZD3965 CAS No. 1448671-31-5	AZD3965 is a selective inhibitor of monocarboxylate transporter 1(MCT1)with a binding affinity of 1.6 nM,is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM.In vivo,AZD3965 is well tolerated and induces a dose and time dependent accumulation of lactate in the tumours,suppresses tumour growth and in the Raji model potentiates the effects of Rituxan,doxorubicin and bendamustine. The selective inhibition of lactate transport by the MCT1 inhibitor AZD3965 offers an novel mechanism for targeting the metabolic phenotype in tumours that preferentially express MCT1.	price>
R-R-3057	CMC2.24 CAS No.1255639-43-0	CMC2.24 (TRB-N0224)/CAS No.1255639-43-0, an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis.	price>
R-C-1358	KS176 CAS No. 1253452-78-6	KS176 is a potent and selective inhibitor of the breast cancer resistance protein(BCRP)multidrug transporter(IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively).Displays no inhibitory activity against P-gp or MRP1.	price>
R-R-3058	Kras4B G12D-IN-1 CAS No.2042365-85-3	Kras4B G12D-IN-1/CAS No.2042365-85-3 is a Kras4B G12D inhibitor with anticancer effects. Kras4B G12D-IN-1 decreases Kras protein expression in mouse embryonic fibroblasts (MEF) expressing Kras4B G12D (WO2016179558A1, Comp 994566).	price>
R-C-1359	PD168393 CAS No. 194423-15-9	PD168393 is a potent,selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2.PD168393 irreversiblely inactivates EGF receptor(IC50=0.7 nM)and is inactive against insulin receptor,PDGFR,FGFR and PKC.	price>
R-R-3059	Ketoconazole-d4 CAS No.1398065-75-2	Ketoconazole-d4/CAS No.1398065-75-2 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.	price>
R-C-1360	GSKJ4HCL CAS No. 1797983-09-5	GSK-J4 is a cell permeable,potent and selective histone demethylase.GSK-J4 is a prodrug of GSK J1,which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.GSK-J4 is used to probe the consequences of demethylation of H3K27me3.GSK-J4 inhibits the lipopolysaccharide-induced production of cytokines,including pro-inflammatory tumour necrosis facto(TNF).	price>
R-R-3060	Atrovastatin-PEG3-FITC CAS No.1440755-31-6	Atrovastatin-PEG3-FITC (compound S31)/CAS No.1440755-31-6 is a KRAS-PDEδ interaction inhibitor. Atrovastatin-PEG3-FITC acts as a ligand in fluorescence anisotropy assay.	price>
R-C-1361	SC66 CAS：871361-88-5	SC66 is a novel and potent AKT inhibitor,which reduced cell viability in a dose- and time-dependent manner,inhibited colony formation and induced apoptosis in HCC cells.SC66 treatment led to a reduction in total and phospho-AKT levels. SC66 significantly potentiated the effects of both conventional chemotherapeutic and targeted agents,doxorubicin and everolimus,respectively.In vivo,SC66 inhibited tumor growth of Hep3B cells in xenograft models,with a similar mechanism observed in the in vitro model.SC66 had antitumor effects on HCC cells.	price>
R-R-3061	Ketoconazole-d8 CAS No.1217706-96-1	Ketoconazole-d8/CAS No.1217706-96-1 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.	price>
R-C-1362	prt4165 CAS No. 31083-55-3	PRT4165 is a small molecule inhibitor of polycomb repressive complex 1,which inhibits ubiquitin signaling at DNA double-strand breaks.PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro.The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks(DSBs),the retention of several DNA damage response proteins in foci that form around DSBs,and the repair of the DSBs.	price>
R-R-3062	Atranorin CAS No.479-20-9	Atranorin/CAS No.479-20-9 is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity.	price>
R-C-1363	Finafloxacin Hydrochloride CAS：209342-41-6	Finafloxacin hydrochloride is used to prepare naphthyridonecarboxylic acid derivatives as drugs for treatment therapy of H.pylori infections and associated gastroduodenal illnesses.	price>
R-R-3063	(S)-JDQ-443 CAS No.2653994-10-4	(S)-JDQ-443/CAS No.2653994-10-4 is an isomer of JDQ-443 (HY-139612). JDQ-443 is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). JDQ-443 shows antitumor activity.	price>
R-C-1364	BLZ945 CAS：953769-46-5	BLZ945 is a potent and selective CSF-1R kinase inhibitor.It attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas.	price>
R-R-3064	Rac1-IN-3 CAS No.380470-06-4	Rac1-IN-3 (Compound 2)/CAS No.380470-06-4 is a Rac1 inhibitor with an IC50 of 46.1 μM.	price>
R-C-1365	Nosiheptide CAS:56377-79-8	Nosiheptide(Multhiomycin),a thiopeptide antibiotic produced by Streptomyces actuosus,inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core.Nosiheptide has been widely used as a feed additive for animal growth.	price>

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