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Catalog	name	Description	price
R-R-3065	(E/Z)-ZINC09659342 CAS No.591726-26-0	(E/Z)-ZINC09659342/CAS No.591726-26-0 is an inhibitor of Lbc-RhoA interaction.	price>
R-C-1366	NQDI-1 CAS：175026-96-7	NQDI-1 is an inhibitor of ASK1,which attenuates acute ischemic renal injury by modulating oxidative stress and cell death.NQDI-1 was used to study LPS-induced activation and role of ASK1 and p38 in anti-inflammatory cytokine production by macrophages Apoptosis signal-regulating kinase 1(ASK1)is among the signaling events that lead to postischemic cell death.Inhibition of ASK1 pathway protected hearts from ischemic damage.	price>
R-R-3066	KRpep-2d TFA	KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research.	price>
R-C-1367	K858 CAS：72926-24-0	K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent,induces cell death in cancer cells.K858 blocked centrosome separation,activated the spindle checkpoint,and induced mitotic arrest in cells accompanied by the formation of monopolar spindles.Long-term continuous treatment of cancer cells with K858 resulted in antiproliferative effects through the induction of mitotic cell death,and polyploidization followed by senescence.K858 exhibited potent antitumor activity in xenograft models of cancer,and induced the accumulation of mitotic cells with monopolar spindles in tumor tissues.	price>
R-R-3067	K-Ras G12C-IN-2 CAS No.1629267-75-9	K-Ras G12C-IN-2/CAS No.1629267-75-9 is an irreversible covalent K-Ras G12C inhibitor.	price>
R-C-1368	PFI-4 CAS：900305-37-5	PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50=80nM).Exhibits>100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2(BRD1),BRPF3 and BRD4.	price>
R-R-3068	K-Ras(G12C) inhibitor 9 CAS No.1469337-91-4	K-Ras (G12C) inhibitor 9/CAS No.1469337-91-4 is an allosteric inhibitor of the K-Ras (G12C).	price>
R-C-1369	AZ5104 CAS：1421373-98-9 CAS：1421373-98-9	AZ 5104 is an active,demethylated metabolite of AZD 9291,an irreversible inhibitor of EGFR-sensitizing and T790M resistance mutations(IC50s=15-17nM) that spares the wild-type form of the receptor(IC50=480 nM).1,2,3 AZ 5104 displays a similar overall activity profile as the parent compound.	price>
R-R-3069	Deltarasin hydrochloride CAS No.1613404-76-4	Deltarasin hydrochloride/CAS No.1613404-76-4 is an inhibitor of KRAS-PDEδinteraction with Kd of 38 nM for binding to purified PDEδ.	price>
R-C-1370	RU58841 CAS：154992-24-2	RU-58841 is a new specific topical antiandrogen:a candidate of choice for the treatment of acne,androgenetic alopecia and hirsutism.The potent localized inhibition of sebaceous glands by RU 58841 demonstrates the excellent potential of this compound as a topical drug for the treatment of acne and other androgen-mediated disorders.	price>
R-R-3070	RBC10 CAS No.362503-73-9	RBC10/CAS No.362503-73-9 is an anti-cancer agent. RBC10 inhibits the binding of Ral to its effector RALBP1. RBC10 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines.	price>
R-C-1371	GNF-7 CAS：839706-07-9	GNF-7 is a multikinase inhibitor.GNF-7 is a Bcr-Abl inhibitor,with IC50s of 133 nM and 61 nM for Bcr-AblWT and Bcr-AblT315I,respectively.GNF-7 also possesses inhibitory activity against both ACK1(activated CDC42 kinase 1) and GCK(germinal center kinase)with IC50s of 25 nM and 8 nM,respectively.GNF-7 can be used for the research of hematologic malignancies.	price>
R-R-3071	KRASG12D-IN-2	KRASG12D-IN-2 (compound 28) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.	price>
R-C-1372	ACT-678689 CAS：1783256-96-1	ACT-678689 is a potent inhibitor of tryptophan hydroxylase 1(TPH1).	price>
R-R-3072	CCG 203769 CAS No.410074-60-1	CCG 203769/CAS No.410074-60-1 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gαo protein-protein interaction in vitro with an IC50 of 17 nM.	price>
R-C-1373	GZD824 CAS：1257628-77-5	Olverembatinib,also known as GZD824,is a novel orally bioavailable inhibitor against a broad spectrum of Bcr-Abl mutants including T315I.GZD824 tightly bound to Bcr-Abl(WT)and Bcr-Abl(T315I)with K(d)values of 0.32 and 0.71 nM, respectively,and strongly inhibited the kinase functions with nanomolar IC(50) values.GZD824 potently suppressed proliferation of Bcr-Abl-positive K562 and Ku812 human CML cells with IC(50)values of 0.2 and 0.13 nM, respectively.GZD824 also displayed good oral bioavailability (48.7%),a reasonable half-life(10.6h), and promising in vivo antitumor efficacy.It induced tumor regression in mouse xenograft tumor models driven by Bcr-Abl(WT)or the mutants and significantly improved the survival of mice bearing an allograft leukemia model with Ba/F3 cells harboring Bcr-Abl(T315I).GZD824 represents a promising lead candidate for development of Bcr-Abl inhibitors to overcome acquired imatinib resistance.(J Med Chem.2013 Feb 14;56(3):879-94).	price>
R-R-3073	CCG-63802 CAS No.620112-78-9	CCG-63802/CAS No.620112-78-9 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gαo interaction, with an IC50 value of 1.9 μM.	price>
R-C-1374	E7050 CAS：928037-13-2	Golvatinib,also known as E7050,is an orally bioavailable dual kinase inhibitor of c-Me,(hepatocyte growth factor receptor)and VEGFR-2(vascular endothelial growth factor receptor-2)tyrosine kinases with potential antineoplastic activity.c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2,which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases.c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth,migration and angiogenesis.	price>
R-R-3074	BMS-192364 CAS No.202822-21-7	BMS-192364/CAS No.202822-21-7 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux.	price>
R-C-1375	Idasanutlin (RG-7388) CAS：1229705-06-9	Idasanutlin,also known as RG7388 and RO5503781,is a highly potent and selective MDM2 antagonist with potential anticancer activity.RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53.By preventing the MDM2-p53 interaction,p53 is not enzymatically degraded and the transcriptional activity of p53 is restored.	price>

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