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Catalog	name	Description	price
R-R-3075	CCG-63808 CAS No.620113-73-7	CCG-63808/CAS No.620113-73-7 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.	price>
R-C-1376	10-deacetyl-7-xylosyl Paclitaxel CAS：90332-63-1	10-deactyl-7-xylosyl Paclitaxel is a disruptor of microtubules and derivative of paclitaxel that has been found in T.chinensis.It induces the disassembly of pig brain and Physarum microtubules in cell-free assays.10-deactyl-7-xylosyl Paclitaxel inhibits proliferation of,as well as induces cell cycle arrest at the G2/M phase and apoptosis in,PC3 prostate cancer cells.	price>
R-R-3076	GTS-21 dihydrochloride CAS No.156223-05-1	GTS-21 dihydrochloride/CAS No.156223-05-1 is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.	price>
R-C-1377	Topotecan CAS:123948-87-8	Topotecan(SKF 104864A;NSC 609669)is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells,2.95±0.23 μM of U87 cells,5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87.	price>
R-R-3077	Olanzapine CAS No.132539-06-1	Olanzapine (LY170053)/CAS No.132539-06-1 is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic.	price>
R-C-1378	BLU-554 CAS:1707289-21-1	Fisogatinib,also known as BLU-554,is a fibroblast growth factor receptor 4 (FGFR4)inhibitor potentially for the treatment of hepatocellular carcinoma and cholangiocarcinoma.Fisogatinib demonstrates clinical benefit and tumor regression in patients with HCC with aberrant FGF19 expression.	price>
R-R-3078	S-15535 CAS No.146998-34-7	S-15535/CAS No.146998-34-7 is a highly selective 5-HT1A receptor ligand. S-15535 is an antagonist of postsynaptic 5-HT1A receptors and an agonist of presynaptic 5-HT1A receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety.	price>
R-C-1379	CUDC-101 CAS:1012054-59-9	CUDC-101 is a multi-targeted,small-molecule inhibitor of histone deacetylase (HDAC),epidermal growth factor receptor tyrosine kinase(EGFR/ErbB1),and human epidermal growth factor receptor 2 tyrosine kinase(HER2/neu or ErbB2)with potential antineoplastic activity.HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown.This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous,synergistic inhibition of EGFR,Her2,and HDAC.	price>
R-R-3079	Clozapine CAS No.5786-21-0	Clozapine (HF 1854)/CAS No.5786-21-0 is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).	price>
R-C-1380	AM580 CAS:102121-60-8	AM-580 is a potent RARalpha agonist.AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.AM580 inhibited the wnt pathway,measured by loss of nuclear beta-catenin,suggesting partial oncogene dependence of therapy.Am580 treatment increased RARbeta and lowered the level of RARgamma,an isotype whose expression we linked with tumor proliferation.	price>
R-R-3080	SB-699551 CAS No.864741-95-7	SB-699551/CAS No.864741-95-7 is a potent and selective 5-HT5A antagonist with a pKi of 8.3. SB-699551 inhibits tumorsphere formation. SB-699551 reduces phosphorylation of AKT at serine residue 473 (S473), WNK1, PRAS40. SB-699551 shows anticancer activity and has the potential for the research of breast tumor.	price>
R-C-1381	Lu AE58054 (Idalopirdine) CAS NO. 467459-31-0	Idalopirdine is a potent and selective 5-HT6 receptor antagonist for potential use in the treatment of cognitive deficits associated with Alzheimer is disease and schizophrenia.	price>
R-R-3081	Puerarin CAS No.3681-99-0	Puerarin/CAS No.3681-99-0, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.	price>
R-C-1382	Volitinib CAS:1313725-88-0	Savolitinib,also known as Volitinib,AZD6094 or HMPL-504,is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity.Volitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner,and disrupts c-Met signal transduction pathways.This may result in cell growth inhibition in tumors that overexpress the c-Met protein.	price>
R-R-3082	Vortioxetine CAS No.508233-74-7	Vortioxetine/CAS No.508233-74-7 is a inhibitor of 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.	price>
R-C-1383	FMK CAS:821794-92-7	FMK is potent,highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2;Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386.Fmk induces significant apoptosis in human FGFR3-expressing,t(4;14)-positive multiple myeloma cells.	price>
R-R-3083	Ondansetron CAS No.99614-02-5	Ondansetron (GR 38032; SN 307)/CAS No.99614-02-5 is a highly selective 5-HT3 receptor antagonist, with IC50 value of 103 pM. Ondansetron exerts antiemetic effects by antagonizing 5-HT receptor located on local neurons in the peripheral and central nervous system. Ondansetron suppresses nausea and vomiting caused by chemotherapy and radiation therapy. Ondansetron has orally bioactivity.	price>
R-C-1384	Voreloxin CAS:175414-77-4	Voreloxin,also known as SNS-595 or Vosaroxin,is a s mall molecule and a naphthyridine analogue with antineoplastic activity.Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result,inhibition of DNA replication,RNA and protein synthesis occurs,followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis.This agent shows a favorable toxicity profile in several aspects:it does not generate reactive oxygen species,as do anthracyclines,reducing the risk of cardiotoxicity.	price>
R-R-3084	Brexpiprazole CAS No.913611-97-9	Brexpiprazole (OPC-34712)/CAS No.913611-97-9, an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM).	price>
R-C-1385	Capadenoson,BAY 68-4986 CAS:544417-40-5	Capadenoson is a selective agonist of adenosine-A1 receptor.	price>

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