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Catalog	name	Description	price
R-R-3126	SB-224289 hydrochloride CAS No.180084-26-8	SB-224289 hydrochloride/CAS No.180084-26-8 is a selective 5-HT1B receptor antagonist, with anxiolytic effect.	price>
R-C-1427	Deracoxib CAS:169590-41-4	Deracoxib is an NSAID and COX-2 inhibitor used to treat osteoarthritis.It induces cell cycle arrest and apoptosis in mammary tumor cells,decreases platelet aggregation,and lowers inflammatory responses.	price>
R-R-3127	SB 204741 CAS No.152239-46-8	SB 204741/CAS No.152239-46-8 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1.	price>
R-C-1428	GW5074 CAS:220904-83-6	GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM,and has no effect on the activities of JNK1/2/3,MEK1,MKK6/7,CDK1/2,c-Src,p38 MAP,VEGFR2 or c-Fms.	price>
R-R-3128	RS-127445 hydrochloride CAS No.199864-86-3	RS-127445 hydrochloride/CAS No.199864-86-3 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.	price>
R-C-1429	Talnetant CAS：174636-32-9	Talnetant is a potent and selective NK3 receptor antagonist(ki=1.4nM,hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor,with no affinity for the hNK-1 at concentrations up to 100 uM.	price>
R-R-3129	Nefazodone hydrochloride CAS No.82752-99-6	Nefazodone hydrochloride (BMY-13754)/CAS No.82752-99-6 is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity.	price>
R-C-1430	Tepoxalin CAS：174636-32-9	Talnetant(SB 223412)is a potent and selective NK3 receptor antagonist(ki=1.4nM, hNK-3-CHO);100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM.	price>
R-R-3130	Trimipramine maleate CAS No.521-78-8	Trimipramine maleate/CAS No.521-78-8 is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine maleate has vascular activity and anxiolytic efficacy.	price>
R-C-1431	Pagoclone CAS：133737-32-3	Pagoclone,an active(+)-enantiomer of the racemate RP 59037,is a ubtype selective partial agonist at GABAA receptor and used for the treatment of panic and anxiety disorders.	price>
R-R-3131	LP-211 CAS No.1052147-86-0	LP-211/CAS No.1052147-86-0 is a selective and blood−brain barrier penetrant 5-HT7 receptor agonist, with a Ki of 0.58 nM, with high selectivity over 5-HT1A receptor (Ki, 188 nM) and D2 receptor (Ki, 142 nM).	price>
R-C-1432	Trovafloxacin CAS：147059-72-1	Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive,Gram-negative and anaerobic organisms.Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity.Trovafloxacin is also a potent,selective and orally active pannexin 1 channel(PANX1)inhibitor with an IC50 of 4 μM for PANX1 inward current.Trovafloxacin does not inhibit connexin 43 gap junction or PANX2.Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1.	price>
R-R-3132	Lurasidone Hydrochloride CAS No.367514-88-3	Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride))/CAS No.367514-88-3 is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.	price>
R-C-1433	LDC000067 CAS：1073485-20-7	LDC000067 is a potent and selective CDK9 inhibitor.LDC000067 inhibited in vitro transcription in an ATP-competitive and dose-dependent manner.Gene expression profiling of cells treated with LDC000067 demonstrated a selective reduction of short-lived mRNAs,including important regulators of proliferation and apoptosis. Analysis of de novo RNA synthesis suggested a wide ranging positive role of CDK9.At the molecular and cellular level,LDC000067 reproduced effects characteristic of CDK9 inhibition such as enhanced pausing of RNA polymerase II on genes and, most importantly,induction of apoptosis in cancer cells.LDC000067 inhibits P-TEFb-dependent in vitro transcription.Induces apoptosis in vitro and in vivo in combination with BI 894999.	price>
R-R-3133	Levomepromazine CAS No.60-99-1	Levomepromazine (Methotrimeprazine)/CAS No.60-99-1 is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors.	price>
R-C-1434	GSK137647A CAS：349085-82-1	GSK137647A is an agonist of the free fatty acid receptor 4(FFA4/GPR120)with pEC50s=6.3,6.2,and 6.1 at human,mouse,and rat receptors,respectively.GSK137647A is selective for GPR120 over a panel of 61 other targets,including other FFARs.	price>
R-R-3134	Gamma-Mangostin CAS No.31271-07-5	Gamma-Mangostin/CAS No.31271-07-5 is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) .	price>
R-C-1435	LLY-507 CAS：1793053-37-8	LLY-507 is a potent and selective inhibitor of protein-lysine methyltransferase SMYD2,LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC50<15 nM.LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.	price>
R-R-3135	Roluperidone CAS No.359625-79-9	Roluperidone (CYR-101)/CAS No.359625-79-9 is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).	price>
R-C-1436	HLCL-61 HCL CAS：1158279-20-9	HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia.HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML(acute myeloid leukemia)cells.As a result,significant antileukemic activity was achieved.The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it.In AML cells,PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3.	price>

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