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Catalog	name	Description	price
R-C-1447	Torin2 CAS:1223001-51-1	Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/−MEFs cell line;800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties.Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively.Torin 2 decreases cell viability and induces autophagy and apoptosis.	price>
R-R-3147	Spadin TFA	Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research.	price>
R-C-1448	BML-210(CAY10433) CAS:537034-17-6	BML-210(CAY10433),is HDAC inhibitor.BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells.BML-210 can inhibit cell growth and induce apoptosis in cervical cancer cells,what correlates with down-regulation of HDAC class I and II and changes in the DAPC expression levels.	price>
R-R-3148	Harmine hydrochloride CAS No.343-27-1	Harmine Hydrochloride (Telepathine Hydrochloride)/CAS No.343-27-1 is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.	price>
R-C-1449	TC-H 106 CAS:937039-45-7	TC-H 106(Pimelic Diphenylamide 106)is a slow,tight-binding inhibitor of class I histone deacetylases(HDAC)with Ki value of 148 nM,about 102 nM,14 nM for HDAC1,HDAC2,HDAC3,respectively.	price>
R-R-3149	Perospirone CAS No.150915-41-6	Perospirone (SM-9018 free base)/CAS No.150915-41-6 is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.	price>
R-C-1450	UF 010 CAS:537672-41-6	UF-010 is a Class I HDAC inhibitor(IC50 values are 0.06,0.1,0.5 and 1.5μM for HDACs 3,2,1 and 8,respectively).UF010 inhibits cancer cell proliferation via class I HDAC inhibition.This causes global changes in protein acetylation and gene expression,resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways.	price>
R-R-3150	AS19 CAS No.1000578-26-6	AS19/CAS No.1000578-26-6 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia.	price>
R-C-1451	KC7F2 CAS:927822-86-4	KC7F2 is an inhibitor of HIF-1αprotein translation,but not transcription,that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1(4EBP1)and p70 S6 kinase(S6K).	price>
R-R-3151	2-Methyl-5-HT CAS No.78263-90-8	2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine)/CAS No.78263-90-8 is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects.	price>
R-C-1452	WDR5 0103 CAS:890190-22-4	WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5(Kd= 450 nM),inhibiting the catalytic activity of the MLL core complex in vitro (IC50=39 µM).WD repeat domain 5(WDR5)plays an important role in various biological functions through the epigenetic regulation of gene transcription. WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis.	price>
R-R-3152	Oxatomide CAS No.60607-34-3	Oxatomide/CAS No.60607-34-3 is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin.	price>
R-C-1453	MN 64 CAS:92831-11-3	MN-64 is a potent tankyrase 1 inhibitor,with IC50s of 6 nM,72 nM,19.1μM,and 39.4μM for TNKS1,TNKS2,ARTD1 and ARTD2,respectively.	price>
R-R-3153	CP94253 hydrochloride CAS No.845861-39-4	CP94253 hydrochloride/CAS No.845861-39-4 is a potent and selective agonist of 5-HT1B receptor (Ki= 2 nM in a radioligand binding assay).Ki values for 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors are 89, 49, 860, and 1600 nM respectively. CP94253 hydrochloride is centrally active upon systemic administration in vivo.	price>
R-C-1454	NCH 51 CAS:848354-66-5	PTACH(NCH-51)is a potent HDAC inhibitor with IC50s of 48 nM,32 nM,and 41 nM for HDAC1,HDAC4,and HDAC6,respectively.PTACH exerts potent growth inhibition against various cancer cells(EC50s of 1.1-9.1 µM) .	price>
R-R-3154	Setiptiline CAS No.57262-94-9	Setiptiline (Org-8282)/CAS No.57262-94-9 is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.	price>
R-C-1455	Betahistine CAS:5638-76-6	Betahistine is a histamine analog and H1 receptor agonist that serves as a vasodilator.It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.Betahistine dihydrochloride is an anti-vertigo drug.It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière is disease.It was first registered in Europe in 1970 for the treatment of Ménière is disease.	price>
R-R-3155	Setiptiline maleate CAS No.85650-57-3	Setiptiline maleate (MO-8282 maleate)/CAS No.85650-57-3 is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.	price>
R-C-1456	NSC19005(Betahistine EP Impurity C) CAS:5452-87-9	Betahistine EP Impurity C(NSC19005)is an impurity of Betahistine.Betahistine is a potent,orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis(RA).	price>
R-R-3156	Lumateperone tosylate CAS No.1187020-80-9	Lumateperone (ITI-007) tosylate/CAS No.1187020-80-9 is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia.	price>

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