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Catalog	name	Description	price
R-C-1467	BMS-3 CAS:1338247-30-5	BMS-3 is a LIM kinase 1(LIMK1)inhibitor.LIMK inhibition with 1μM BMS-3 damaged MTOC protein localisation to spindle poles,undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment.These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes.LIM kinase 1(LIMK1)activity is essential for cell migration and cell cycle progression.	price>
R-R-3167	Rizatriptan benzoate CAS No.145202-66-0	Rizatriptan Benzoate(Maxalt)/CAS No.145202-66-0 is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.	price>
R-C-1468	ISX9 CAS:832115-62-5	Isoxazole 9(Isx-9)is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells(NSPCs).Isoxazole 9(Isx-9)activates multiple pathways including TGF-β induced epithelial–mesenchymal transition(EMT)signaling,canonical and non-canonical Wnt signaling at different stages of cardiac differentiation.	price>
R-R-3168	Nefazodone CAS No.83366-66-9	Nefazodone/CAS No.83366-66-9 is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction.	price>
R-C-1469	U104(NSC 213841/MST104) CAS:178606-66-1	U-104(MST-104,NSC 213841,SLC-0111,WBI-5111)is a potent carbonic anhydrase(CA) inhibitor for CA IX and CA XII with Ki of 45.1nM and 4.5nM,respectively,very low inhibition for CA I and CA II.	price>
R-R-3169	SB 242084 dihydrochloride CAS No.1049747-87-6	SB 242084 dihydrochloride/CAS No.1049747-87-6 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 dihydrochloride increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 dihydrochloride also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 dihydrochloride has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage.	price>
R-C-1470	MK0812 CAS:624733-88-6	MK-0812 is a potent and selective CCR2 antagonist.Chemokine(C-C motif)receptor 2(CCR2)is central for the migration of monocytes into inflamed tissues.The inhibition of CCR2 signaling represents a potential therapeutic approach for treatment of metastasis without affecting homeostatic functions.	price>
R-R-3170	F-15599 CAS No.635323-95-4	F-15599/CAS No.635323-95-4 is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM.	price>
R-C-1471	MLN2480 CAS:1096708-71-2	MLN2480(BIIB-024,TAK580,AMG-2112819,BSK1369,DAY-101)is an oral,selective pan-Raf kinase inhibitor in chinical trials.	price>
R-R-3171	Latrepirdine dihydrochloride CAS No.97657-92-6	Latrepirdine dihydrochloride/CAS No.97657-92-6 is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.	price>
R-C-1472	CP544326 (Taprenepag) CAS:752187-80-7	Taprenepag(CP-544326)is a potent and selective prostaglandin EP(2)agonist with IC50s of 10 and 15 nM for human and rat EP2,respectively.Taprenepag shows selectivity for EP2 over other EP receptors(IC50s>3200 nM for EP1,EP3,and EP4)and a panel of 37G protein-coupled receptors.	price>
R-R-3172	Cyproheptadine CAS No.129-03-3	Cyproheptadine/CAS No.129-03-3 is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders.	price>
R-C-1473	ZM241385 CAS:139180-30-6	ZM-241385 is a potent and highly selective Adenosine A2A-R antagonist,with a pA2 of 9.02 for Adenosine A2A-R in cardiac vasculature and selectivities of 1000,91 and 500,000 over Adenosine A1-R,Adenosine A2B-R and Adenosine A3-R sites, respectively.	price>
R-R-3173	JNJ-18038683 CAS No.851376-05-1	JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively.	price>
R-C-1474	BX-912 CAS:702674-56-4	BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM,9-and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively.In comparison to GSK3β,selectivity for PDK1 is 600-fold.	price>
R-R-3174	Ocaperidone CAS No.129029-23-8	Ocaperidone/CAS No.129029-23-8 is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A.	price>
R-C-1475	PGA-PEG-malemide	Polyglutamic acid（γ-PGA,also known as natto gum and polyglutamic acid,is a kind of water-soluble,biodegradable,non-toxic biopolymer produced by microbial fermentation.Polyethylene glycol(PEG)is a kind of high molecular polymer,the chemical formula is ho(CH2CH2O)NH,which has no irritation,slightly bitter taste,good water solubility and good compatibility with many organic components.	price>
R-R-3175	Phenylbiguanide CAS No.102-02-3	Phenylbiguanide/CAS No.102-02-3 is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.	price>
R-C-1476	MK-3697 CAS:1224846-01-8	MK-3697 is a highly potent,orally bioavailable selective orexin 2 receptor antagonists.MK-3697 is also the third insomnia drug,currently being developed by Merck.MK-3697 has Ki=0.95nM.Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia.In vivo tests results on MK-3697 demonstrated improved stability and TDI profiles as well as excellent sleep efficacy across species.	price>
R-R-3176	Zacopride hydrochloride CAS No.101303-98-4	Zacopride hydrochloride/CAS No.101303-98-4 is a highly potent 5-HT3 receptor antagonist with Kis of 0.38 and 373 nM for 5-HT3 and 5-HT4 receptor, respectively. Zacopride hydrochloride is also a moderate IK1 channel agonist. Zacopride hydrochloride exerts significant antiarrhythmic and cardiac protective effects.	price>

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